I'm in the same boat. I've been on chemo or clinical trials for 8 of the last nine years (I had one year of NED). My personal approach is to find a level of treatment that is physically & psychologically tolerable. Sometimes that's high, sometimes it's low, but I always want to be in charge of my own chemo dosing. y oncologist has been with me on that. Right now I'm on a 50% Stivarga as II look for the next clinical trial.