H.pylori and Lynch Syndrome

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sonya7118
Posts: 4
Joined: Wed Aug 30, 2017 10:03 am

H.pylori and Lynch Syndrome

Postby sonya7118 » Thu Sep 07, 2017 1:17 am

Anyone have this? I've read medical journals stating it could be the first stage to stomach cancer, I had no idea I had it, I have never had heartburn in my life.
Can someone shine a light on this for me?

NHMike
Posts: 2555
Joined: Fri Jul 21, 2017 3:43 am

Re: H.pylori and Lynch Syndrome

Postby NHMike » Thu Sep 07, 2017 5:48 am

I think that I discussed this with my son a while ago. All I can recall is something about the harsh environment making it more likely for mutations to occur.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8, 2/12 1.2
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal
2/19: Clean CT


veckon
Posts: 131
Joined: Thu Jul 27, 2017 7:44 am

Re: H.pylori and Lynch Syndrome

Postby veckon » Thu Sep 07, 2017 8:04 am

Lynch already indicates you have a dramatically increased risk for gastric cancer. At a certain age, your doctor should start scoping you.
27 yo male
Metastatic rectal cancer diagnosed 12/16
Liver metastases and peritoneal carcinomatosis
Lynch syndrome, MSI-H
Failed liver resection 3/17
FOLFOX6 12/16 - 05/17
Keytruda 5/17 - present
@Memorial Sloan Kettering

rockhound
Posts: 113
Joined: Fri Jul 14, 2017 5:00 pm

Re: H.pylori and Lynch Syndrome

Postby rockhound » Fri Sep 08, 2017 3:01 pm

If you know you are Lynch positive, I would suggest talking to a genetic counselor. They can provide you with actual statistics about the other Lynch cancers (not all Lynch mutations have the same cancer risks) as well as suggest screening schedules. For example, if I would have known I was Lynch positive, I would have started annual colonoscopies at age 25 (oops!). Also, for me, it was recommended that I get an upper GI endoscopy every two years (but annual colonoscopy). I am also going to start seeing a GI doc in a high-risk Gi clinic.

Also, remember that statistics are statistics- my parent carries the same mutation but is 75, eats a diet of crappy beer, steaks, burgers, and potato chips (basically that's it) - no cancer or any related issues. So just because your risk for something is higher than "normal" does not mean that something is going to occur...of course the enhanced risk is why you want to be proactive about the screening......
45 yr old male
Diagnosed December 2016, age 41
Stage 1/IIA rectal cancer - T2/3N0M0 via MRI (MRI indicates stage 1; onc/surgeon = stage 2a)
Lynch syndrome, MSH6 mutation, MSI
2 to 3/2017 Xeloda + Radiation
5/10/17 - Robotic LAR with temp. loop illeostomy, 0/20 lymph nodes
6 to 7/2017 - Six cycles Folfox @ full strength
9/20/17 - Ileostomy takedown
10/17 - CT, NED
5/18 - CT, NED
11/18 - CT, NED
5/19 - CT, NED..moving to yearly CT scans
5/20 - CT, NED
5/21 - CT, NED (4 yr. scan)


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