IMMUNO combo trial for Stage II and higher rectal ca working :)

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Maia
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Joined: Fri Aug 24, 2012 8:00 am

IMMUNO combo trial for Stage II and higher rectal ca working :)

Postby Maia » Fri Sep 01, 2017 10:39 am

Oregon August 31, 2017

Good news from trial NCT02688712, for Stage II rectal cancer receiving first treatment, to illustrate why and how clinical trials shouldn't be considered something to try after everything failed.

* Chemoradiation+ Xeloda or 5-Fu + IMMUNOTHERAPY (TGFβ Type I Receptor Inhibitor LY2157299)

* Only in Providence, Oregon.

ExIST Study of LY2157299 (Galunisertib) in Rectal Cancer

''The first three patients to participate in the clinical trial have shown a “dramatic response,” according to Dr. Young. One patient’s tumor completely disappeared, while the two other patients had more than a 75 percent decrease in tumor size, with equally impressive responses in the lymph nodes. ''
[...]
''The trial is open to patients with Stage 2 and higher rectal cancer who are slated to undergo the standard treatment of radiation and chemotherapy prior to surgery. The clinical trial adds an additional component to the pre-surgery radiation/chemotherapy regimen – immunotherapy. It is administered in the form of daily pills for two weeks prior to radiation and chemotherapy, and then during that treatment as well.''
http://www.prweb.com/releases/2017/08/prweb14644140.htm

The trial page: https://clinicaltrials.gov/ct2/show/NCT02688712

mozart13
Posts: 154
Joined: Fri Dec 09, 2016 7:38 pm
Location: Toronto

Re: IMMUNO combo trial for Stage II and higher rectal ca working :)

Postby mozart13 » Fri Sep 01, 2017 11:57 am

Thx Maia
That is excellent news, in time maybe will get to the point where rectal cancer will be treated only chemically with radiation.
55 year at the time of diagnosis, male
Diagnosed with T1,T2 N0 M0 rectal cancer
Total neoadjuvant therapy or TNT (chemoradiation followed by systemic chemotherapy)
Negative since Feb. '17
No surgery
Watch&Wait approach 8)
I don’t come much to the forum , so if this is not updated it means I remain negative!
Wish good luck to all!

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Maia
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Joined: Fri Aug 24, 2012 8:00 am

Re: IMMUNO combo trial for Stage II and higher rectal ca working :)

Postby Maia » Fri Sep 01, 2017 12:28 pm

Yep, look at you.
Or even without radiation. Look at this trial about to open in Canada: https://clinicaltrials.gov/ct2/show/NCT03259035

NHMike
Posts: 2422
Joined: Fri Jul 21, 2017 3:43 am

Re: IMMUNO combo trial for Stage II and higher rectal ca working :)

Postby NHMike » Fri Sep 01, 2017 12:35 pm

Very cool.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8, 2/12 1.2
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal
2/19: Clean CT

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juliej
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Joined: Thu Aug 05, 2010 12:59 pm

Re: IMMUNO combo trial for Stage II and higher rectal ca working :)

Postby juliej » Fri Sep 01, 2017 5:33 pm

Maia wrote:Yep, look at you.
Or even without radiation. Look at this trial about to open in Canada: https://clinicaltrials.gov/ct2/show/NCT03259035

I'm for "no radiation" !!!

My GI surgeon at MSK did a trial involving a chemo-only approach to rectal cancer. I think adding immunotherapy to the mix might be just what's needed to increase the efficacy.

I didn't have radiation but only because I was a Stage 4B at diagnosis. There was no plan for surgery of any kind, just chemo for life. When MSK decided to take a chance on me, they went straight to surgery, no radiation whatsoever. At that point, I'd been on chemo for nearly 2 years and had a significant response to it. My GI surgeon said it's much easier to operate on rectal cancer patients who haven't had radiation because it thins the tissue and makes it brittle. Also, patients who don't have radiation have a better outcome in terms of bowel frequency, urgency, etc. than radiation patients. Getting away from burning the delicate tissue in that area would be a godsend.

Hugs to you, Maia, from your fellow zombie fighter!

xoxoxo,
Juliej
Stage IVb, liver/lung mets 8/4/2010
Xelox+Avastin 8/18/10 to 10/21/2011
LAR, liver resec, HAI pump 11/2011
Adjuvant Irinotecan + FUDR
Double lung surgery + ileo reversal 2/2012
Adjuvant FUDR + Xeloda
VATS rt. lung 12/2012 - benign granuloma!
VATS left lung 11/2013
NED 11/22/13 to 12/18/2019, CEA<1

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Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Re: IMMUNO combo trial for Stage II and higher rectal ca working :)

Postby Maia » Sat Sep 02, 2017 4:08 pm

I never get tired of being in awe at your ''journey'', as our CRGuy says, my dear fellow zombie fighter.
Hey, slowly, we are getting down more zombies in the last years, uh. 8)

Lee
Posts: 6034
Joined: Sun Apr 16, 2006 4:09 pm

Re: IMMUNO combo trial for Stage II and higher rectal ca working :)

Postby Lee » Sat Sep 02, 2017 4:26 pm

I sure wish this had been around when I was going through all of this. Radiation was the worse for me. The very reason why I have a permanent colostomy bag today.

thank you Maia for sharing. A promising future many people just starting this journey.

Lee
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 10 years and counting!

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Shana
Posts: 401
Joined: Sun Jul 30, 2017 9:45 pm
Location: Sonoma, CA

Re: IMMUNO combo trial for Stage II and higher rectal ca working :)

Postby Shana » Sat Sep 02, 2017 8:47 pm

Awesome news, Maia! That's so promising and hopeful!

Thanks for sharing :)
DX - 12/16
MSS - KRAS wild
Well-differentiated adenocarcinoma at splenic flexure
Stage IV CC with liver mets
5FU - Failed twice - 1/17 and 3/17
Irinotecan + Cetuximab: 8/17
Irinotecan and Erbitux ran it's course. CEA rising
Primary tumor invaded tail of pancreas and spleen. Liver mets major concern
Y-90 radioembolization on 9/17/18, liver enzyymes have dropped. 10 Radiation treatments to primary tumor completed too. CT scan Nov to assess overall situation...


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