veckon wrote:the difference between this drug and keytruda? Looks like both are pd-1 inhibitors. I wonder if you stop responding to one, another might work depending on what exactly differentiates this drug.
Maia wrote:veckon wrote:the difference between this drug and keytruda? Looks like both are pd-1 inhibitors. I wonder if you stop responding to one, another might work depending on what exactly differentiates this drug.
Keytruda (pembrolizumab) and Opdivo (nivolumab) are both anti PD-1. They are too similar. Even drugs that are anti PD-L1 (those that act on the same pathway, but attach to the ligand --the 'L'--in the cancer cell) are considered clinically similar (those drugs are Tecentriq --atezolizumab--, Imfinzi --durvalumab--, Bavencio --avelumab). If an MSI-high patient stops responding to any of them, the next rational step would be trying a combination, like the ones being tried for MSS: anti PD-1 + Avastin / anti PD-1 + targeted agent, like a MEK inhibitor, anti PD-1 + chemotherapy.
Maybe it does make sense to try, in that combination, an anti PD-L1, if one already had an anti PD-1.
About the difference of effectiveness between Keytruda and Opdivo, I'm still reading and trying to understand the numbers --and waiting for someone that really knows, no an aficionado like me, to publish an article today LOLOL
One difference is that Opdivo was approved only for MSH-high colorectal cancer and Keytruda for any type of cancer, like pancreatic, lung, ovarian, etc., that is MSI-High.
veckon wrote:Maia wrote:veckon wrote:the difference between this drug and keytruda? Looks like both are pd-1 inhibitors. I wonder if you stop responding to one, another might work depending on what exactly differentiates this drug.
Keytruda (pembrolizumab) and Opdivo (nivolumab) are both anti PD-1. They are too similar. Even drugs that are anti PD-L1 (those that act on the same pathway, but attach to the ligand --the 'L'--in the cancer cell) are considered clinically similar (those drugs are Tecentriq --atezolizumab--, Imfinzi --durvalumab--, Bavencio --avelumab). If an MSI-high patient stops responding to any of them, the next rational step would be trying a combination, like the ones being tried for MSS: anti PD-1 + Avastin / anti PD-1 + targeted agent, like a MEK inhibitor, anti PD-1 + chemotherapy.
Maybe it does make sense to try, in that combination, an anti PD-L1, if one already had an anti PD-1.
About the difference of effectiveness between Keytruda and Opdivo, I'm still reading and trying to understand the numbers --and waiting for someone that really knows, no an aficionado like me, to publish an article today LOLOL
One difference is that Opdivo was approved only for MSH-high colorectal cancer and Keytruda for any type of cancer, like pancreatic, lung, ovarian, etc., that is MSI-High.
Thanks for the information. Very interesting. It was also really striking to see the differences in response for both drugs. Clinical complete response rate seems to be significantly higher with keytruda. I’m going to ask my doctor about it next week.
Robino1 wrote:What an amazing drop in your CEA number!!!
Sounds like Opdivo is working splendidly for you
henry123 wrote:I have a question as to why are patients on Opdivo told to avoid sunlight exposure.
Any new update on Keytruda or Opdivo?
Lee wrote:henry123 wrote:I have a question as to why are patients on Opdivo told to avoid sunlight exposure.
Any new update on Keytruda or Opdivo?
I was on FOLFOX only, butt I too was told to avoid the sun. If I remember correctly it makes you more susceptible to sunburns.
Are you just taking Opdivo alone or in conjunction with chemo?
Lee
henry123 wrote:Monotherapy. Just Nivolumab.
Oncologist even stopped all supplements and multivitamins I was taking earlier.
He was especially strict that steroid or sterol based supplements and medicines should be avoided as they may interfere with working of Opdivo.
He emphasised on movement and light exercises a lot.
Now , he is telling me to get back into normal work routine . It is a bit tough mentally as just 6 7 months ago , I was in a different frame of mind ( with nothing working).
Can someone guide me how to make the transition from state of mind where you are ready to leave this world to possibility of being ok for whatever time
henry123 wrote:Hello
My latest cea value is 3.6
Almost normal.
Hopefully under 3 by next month .
Fingers crossed.
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