rp1954 wrote:If you are still KRAS/BRAF wild (CA199 and LDH [~LDH4/5] are still low like earlier?), that sounds good. We seem to deal with several populations, but I'm not as studied on the wild ones. Largely we were able to cut the worst KRAS wild survivors out 6 years ago, and some part of our program has been successful with oral chemo+celecoxib Mand supplements suppressing CEA surges (Kras wild tends to show as CEA drops with Erbitux) over time by revving various immune components.
I'd probably be looking at your MCV and CEA history more closely if they're not too noisy from cyclical chemo. Trying out the 2010 Life Extension supplements (including things like PSK and plainer supplements) without worrying about the cimetidine but perhaps doing WGP and Prendergast's high vitamin D3/K2 because that roughly corresponds to what suppressed CEA surges with the oral chemo and celecoxib. For us, chemo is not so low dose (daily averaged toward the total cyclic 5FU dose) as much as we suppress side effects with various nutrient strategies.
Thanks again rp1954. I've been on a quest for some good blood-work markers since reading your posts early. I didn't get pre-surgery numbers but got one test in pre-chemo with normal CEA and CA19-9. Since then I added things a little liberally (with the initial support of my Onc who shut me down after I ordered ddimer and it caused a commotion) I think FolFox made a bit of a mess of some so I still don't have much to go on. I plan on getting a bunch re-run on my blood test this coming week as I've been off 5 weeks now.
Having good blood indicators would be much more reassuring as a monitoring tool....
If someone can see something in this data please chime in!
CEA (Roche assay) - Jan: 2.8 (pre-chemo), 2.8 Feb: 4.9, 4.7 Mar: 4.2, 3.7 Apr: 3.6, 2.9 May: 2.3, 2.7 June: 2.7, 2.7. July 2.8 (off Chemo 5 weeks). From this I don't see CEA as much of a marker although it did spike after a few Folfox Treatments.
CA 19-9- Jan: 7 (pre-chemo) Feb: 9 Mar: 11. Apr: 11 - Discontinued as Onc doesn't think it's a marker.
CA 15-3 March: 39 - this is higher than normal but Onc says Chemo havoc, will request a retest.
CA 125 Jan: 20 - this is high but in the normal range. Will request a re-test.
LDH - Jan: 136 )pre-chemo, never outside of norm spiked at 199 in the middle of FolFox and now July 136 again after being off Chemo 5 weeks. Doesn't seem useful as a marker.
ddmer - March = Normal
ESR: 8, 6, 5, 7, 10, 31 (infected wisdom tooth), 10.
MCV: Between 88-92 every test since January.
Whats it all mean?
40 yo Male. BC Canada. Sigmoid Colectomy Dec. 2016
Pathology T3N2bM1 19 of 24 Nodes Positive + tumour deposits
PET scan - Para-Aortic and Iliac Lymph node spread. Stage VI.
Moderately differentiated. MSS. KRAS/BRAF Wild.
Mutations: TP53, ERBB4, MLL3, PDCD1LG2, PRKDC, SMAD3
FOLFOX Commenced Jan 9/2017 - Avastin(Bev) added after round 1.
June 2017 Dose Reduction on Round 11 due to Neuropathy.
Good PET Scan July 2017 - on maintenance 5FU/Bev every 2 weeks until progression.