I am mostly off line this past week, sole ISP problems where we live. Was angry, then wife exchanging views with lineman on the pole, wife heard from someone else there, who has been offline since 7/15
I am hurrying here. I have no experience with the CA15-3 marker, but looking for a potential personnel marker, I might repeat that marker several times over a year if not more frequently, depending on the chemo havoc aspect and your venture interest. There is a paper that suggests that CA15-3 value if undistorted
is of CRC interest if the labs' reference intervals are similar. One winds up tracking down examples and papers to see how fast which markers recover from chemo over the following 3 -12 months.
The CRC literature I've seen would call your CA19-9, LDH relatively favorable with respect to mets and are statistically consistent with Kras wild patients that don't benefit from cimetidine or perhaps IV vitamin C (that serum reading wouldn't be conclusive by itself though, tissue staining is the definitive method). Those CEA values suggest a PSK-chemo benefit might be possible.
I'm not sure your MCV values had enough initial treatment time to buildup and react to chemo, vs whether the chemo was active. Once a full chemo activity buildup occurs with MCV, the MCV reaction times to chemo appear much faster, especially in a chemo failure mode. We have had a lot of favorable experience with MCV and chemo activity, where/when the CA199 and LDH are in a danger zone.
The doctor shutting you down on D-dimer is thinking that d-dimer is 98%-99% selective for embolisms. "Quantitative d-dimer" was the latest type in 2010-11 and was most suited for its CRC information content. What he doesn't know about is that high values for some mCRC patients about to get in catastrophic trouble might be 50-50% which potentially terminal process is happening and needs to paid careful attention in any case. I found several D-dimer-CRC papers because of several surprise endings here. I hate surprises and wanted a good, less specific marker not dependent on CEA. Also very low D-dimer is some slight reassurance in the dimer's lowest range that the coast (NED) is really clear.
We've been adding celecoxib to her daily maintenance chemo tx for about 5 years to help club the CEA and CA19-9 values down and into stasis. She takes natural blood thinners and low dose aspirin with varied regularity, depending on pill fatigue.