ADAPT and Celebrex - What happened?

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Sophy
Posts: 251
Joined: Fri May 27, 2011 2:46 am
Location: New Zealand

Re: ADAPT and Celebrex - What happened?

Postby Sophy » Tue Oct 09, 2018 3:12 am

I am still on ADAPT and CT last week shows still NED since last surgery in August 2014.

I have a good quality of life and so will probably carry on with this. I take cimetedine as well.
dx T3N1M0 Feb 11 when children age 11, 7 and 2
Xeloda/rad March 11, LAR June 11 temp ileo
Xelox 6 rounds, NED
Lung mets Oct 13
Laser surgery Germany Jan 14. 3 mets left lung.
Laser surgery UK Jun and Aug 14 one met each lung, NED
Aug 14 Started Xeloda and Celebrex (ADAPT)
June 2020 CT shows still NED
Continuing ADAPT

Thedruid
Posts: 1
Joined: Tue Aug 21, 2018 1:49 pm
Facebook Username: theDruid

Re: ADAPT and Celebrex - What happened?

Postby Thedruid » Tue Oct 09, 2018 8:12 pm

Hello, StevieB

And what are the ususal side effects of such protocol ? The usual nausea caused by Xeloda only ?

Thanks!
_____________________________________
Diagnosed 07/16/18, age 43
Colon Resection 03/08/18,
Stage 3B colon cancer, T3N2aMO
Lymph-vascular invasion confirmed
6/16 lymph nodes
Port installed in 08/25/18
FOLFOX started in 08/29/18

Brearmstrong
Posts: 95
Joined: Sun Mar 26, 2017 3:24 pm
Location: CT

Re: ADAPT and Celebrex - What happened?

Postby Brearmstrong » Wed Oct 10, 2018 6:19 am

Good to hear that you are both doing well. StevieB, how did you get it approved? Where you part of a trial? Thanks!

-Brenda
48 F Jan 17 2 sons
tumor appendix/colon
Muc Adeno 4cm
mod diff G2 T4aN2
nodes 8/50
CEA 4.6 after surgery <.05
KRAS G12D MSS
FOLFOX Apr-sep 17
Clean CT Jul 2017, oct 17, CEA 3.4, 8.1. May 18 2.3,1.0,1.3, 1.3, 1.0, 2.3, 2.2, 2.1,2.2,1.6,1.4,1.5,2.8,2.2
Oct 2017 clean CT
Nov 17 PET para aortic nodes Stage IV
Folfori w/avastin Dec 17
May 18- surgery on nodes xeloda continues
Aug 18-CT NED Clear CT's Nov 18-May 20
July 20- confirmed recurrence on Rt ovary 3.5 cm CEA 4.0 waiting on plan

stevieb
Posts: 407
Joined: Sat Feb 09, 2013 12:26 am

Re: ADAPT and Celebrex - What happened?

Postby stevieb » Thu Oct 11, 2018 10:42 pm

I really don’t have much side effects. The only thing that I get is a stool that somewhat burns, almost like a virus, when on the Xeloda. Other than that, I feel pretty normal.

It was not part of a trial but I had my local onc call Dr Lin and get the protocol for me to follow and my onc at MDA neither approved nor disapproved of me adding the Celebrex. He finds it intriguing that I have no HFS and I keep telling him it is bc of the Celebrex!!
Dx age 33
12/19/12 Stage IV liver/lung
1/14-2/28/13 Folfox
3/27/13 rectal/lung rst; temp ileo
7/11/13 liver res/ileo rev
9/30/13 - Folfox
11/13,2/21 NED
3/14 lung recur;6/16-VATS
7/14 5 bi lung mets
10&11/15 laser lung surg
2015 Colondar Model
12/15 5 lung met-folfiri
5/15 NED
11/15 2 lung mets; cryoablation
1/4/17 2 lung mets; cryoablation
NED as of 1/23/17

DBF
Posts: 319
Joined: Fri Jun 07, 2013 1:44 pm
Facebook Username: https://www.facebook.com/#!/profile.php?id=1000008
Location: New York

Re: ADAPT and Celebrex - What happened?

Postby DBF » Mon Oct 15, 2018 5:00 am

I was on the ADAPT protocol for three years. 2000 X/ 400 C. I never got HFS either- I never made the connection with the Celebrex! That’s very interesting.
I went off this past Memorial Day because I’d been NED for some time. I have a scan 11/8.

Best,
Donna
6/13 Dx @ 29 Wks pregnant, 42 yo
Adenocarcinoma, mucinous
7/13 C-sec/col resec/part. hysterectomy
8/13 Pulm embolism
8/13 Spread to liver
9/13 Liver resection
FOLFOX
CEA UP
ADAPT: Xeloda/Celebrex
2/14 oopherectomy
10/15 obstruction surg
10/17 Scar tissue removal/vsg surg
2019: NED :D
Mom to 3 boys: 21, 10 & 6

Brearmstrong
Posts: 95
Joined: Sun Mar 26, 2017 3:24 pm
Location: CT

Re: ADAPT and Celebrex - What happened?

Postby Brearmstrong » Mon Oct 15, 2018 12:31 pm

Thank you Donna and great news on being able to come off of adapt. I wish you NED forever!!! How did you get approval for it? Did you ask you oncologist or did they just put you on it? I'm taking 2000mg of xeloda a day but just not convinced it's doing enough to keep me NED.

Thanks!

-Brenda
48 F Jan 17 2 sons
tumor appendix/colon
Muc Adeno 4cm
mod diff G2 T4aN2
nodes 8/50
CEA 4.6 after surgery <.05
KRAS G12D MSS
FOLFOX Apr-sep 17
Clean CT Jul 2017, oct 17, CEA 3.4, 8.1. May 18 2.3,1.0,1.3, 1.3, 1.0, 2.3, 2.2, 2.1,2.2,1.6,1.4,1.5,2.8,2.2
Oct 2017 clean CT
Nov 17 PET para aortic nodes Stage IV
Folfori w/avastin Dec 17
May 18- surgery on nodes xeloda continues
Aug 18-CT NED Clear CT's Nov 18-May 20
July 20- confirmed recurrence on Rt ovary 3.5 cm CEA 4.0 waiting on plan

Abhaya
Posts: 1
Joined: Wed Nov 28, 2018 1:59 pm
Facebook Username: Penny mckenna

Re: ADAPT and Celebrex - What happened?

Postby Abhaya » Tue Jul 14, 2020 11:40 pm

My daughter has been stable on this protocol for 2.5 years, not as part of the trial though. I had run into this trial diring my research to help my daughter. I was waiting for the right time to approach her onc with this so when he wanted to give her a chemo holiday in Jan ‘18, she was afraid. Thats when I suggested Adapt. He was positive towards it but said he’d like to add avastin. She’s done very well so far. Mild/moderate hand/foot but feels good and is living her regular life... a great blessing. I don’t understand what happened to this trial. I’ve run into numbers of people still on it or implementing it on their own. I’ve heard that Dr Lin is back at Fred Hutch in Seattle. I also heard there might be a similar trial being designed but I don’t know....anybody?

I_will_fight
Posts: 34
Joined: Mon Jun 29, 2020 3:38 pm

Re: ADAPT and Celebrex - What happened?

Postby I_will_fight » Wed Jul 15, 2020 1:34 am

Thanks to everyone in this thread, I am writing this down and hope to bring it up to my oncologist when I finally get to see him (or her)

Seems like Celecoxib increases heart risk, but I guess for most of us this is an acceptable risk.

JC
46 yo male at DX
June 2020 - 6 cm T3N0 cancer on left colon
No evidence of liver mets, two milimetric dots in lung (non specific)
July 8th 2020 - 50 cm colon and spleen removed
lymph nodes 37/0
MSH6 non expressed, other MMR proteins present

boxhill
Posts: 569
Joined: Fri Apr 06, 2018 11:40 am

Re: ADAPT and Celebrex - What happened?

Postby boxhill » Fri Jul 17, 2020 5:58 pm

I've been taking celecoxib since December 2019 for the bad joint pain I've suffered as a side effect of Keytruda. Everything still hurt, but significantly less.

What is it supposed to do as part of the ADAPT protocol? My understanding is that it is a COX2 inhibitor, so helps with inflammation. I've never seen anything about anti-cancer effects.
F, 64 at DX CRC Stage IV
3/17/18 blockage, r hemi
11 of 25 nodes,5 mesentery nodes
5mm liver met out
pT3 pN2b pM1
BRAF wild, KRAS G12D
dMMR, MSI-H
5/18 FOLFOX
7/18 CT NED
11/18 CT NED
12/18 MRI 5mm liver mass, 2 lymph nodes in porta hepatis
12/31/18 Keytruda
6/19 Multiphasic CT LNs normal, Liver stable
6/28/19 Pause Key, predisone for joint pain
7/31/19 Restart Key
9/19 CT stable
Pain: all fails but Celebrex
12/23/19 CT stable
5/19 MRI stable/NED
Suspend treatment

rp1954
Posts: 1528
Joined: Mon Jun 13, 2011 1:13 am

Re: ADAPT and Celebrex - What happened?

Postby rp1954 » Mon Jul 20, 2020 5:11 pm

My wife took celecoxib at 300-400 mg per day, with her daily chemo (and lots of carefully selected supplements), for over five years. Early in our chemo-supplements-celecoxib series, her markers rose but liver panels were good at 200 mg. At 300 mg her markers were stable or slightly depressed and liver markers very slightly affected; at 400 mg her markers improved but her liver panels had some rise. Over time we adjusted mostly UFT-LV loading and supplements for a better therapeutic index. After chemo she continued celecoxib for part of a year. She still does a fair amount of supplements e.g. IVC, big D, vit K2, beta glucans, resveratrol etc.

My wife started celecoxib at 2.8 years out from diagnosis to increase chemo's effect. Along the way she had 2-3 periods of hypercoagulability, that might be cancer, chemo and/or coxib related.
Stop? Damned if you do, damned if you don't - markers can rise and run.

Basically if she ran short on any category, chemo (UFT/5FU-LV), IV vitamin C, supplements, or celecoxib, her marker(s) would rise. So sometimes it became a juggling act to beat down coagulability and cancer markers, mostly by adjusting celecoxib and supplements several ways based on their various properties and case specifics.

She has been chemo free for two years now, after two surgeries and 8 years of chemo and 10 years of supplements. Careful, combined use of celecoxib, oral chemo, and substantial selected supplements worked for us.
watchful, active researcher and caregiver for stage IVb/c CC. surgeries 4/10 sigmoid etc & 5/11 para-aortic LN cluster; 8 yrs immuno-Chemo for mCRC; now no chemo
most of 2010 Life Extension recommendations and possibilities + more, some (much) higher, peaking ~2011-12, taper to almost nothing mid 2018, mostly IV C

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beach sunrise
Posts: 157
Joined: Thu Mar 05, 2020 7:14 pm

Re: ADAPT and Celebrex - What happened?

Postby beach sunrise » Mon Jul 20, 2020 11:33 pm

I am so happy for you two that she is off chemo!!! Hopefully forever!!!
Both of you are are such an inspiration!!!
It is a juggling act for sure to get the markers down and keep them down.
Dx 8/19, RC, CEA 86, clinical T3N0M0
Neoadj 5FU/rad 6 wks
Surg 1-21-20 APR ostomy, - margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24/post 5.9
Adj mFOLFOX6, cea 7
8 rds 6-10 CEA 11.4, 4 more no oxa
6-17: CEA 11.1 AFP 11.2 CA125 25.7 CA199 9
7-2: CEA 11.1 AFP 5.3 CA125 24.8 CA199 8
7-16: CEA 10.3 AFP 5.3 CA125 26.6 CA199 8
7-28 CEA 8.8 AFP 7.7 CA125 27 CA199 7
MHL1+
PMS2+
MSH2+
MSH6+
Chemo sensitivity test NCI "Test failed, neo-adj chemorad did its job. Not enough ca. cells to test."

Achilles Torn
Posts: 121
Joined: Fri Dec 16, 2016 2:41 pm

Re: ADAPT and Celebrex - What happened?

Postby Achilles Torn » Tue Jul 21, 2020 1:11 pm

I've always been interest in Celebrex and recently ran across various versions of this
https://pubmed.ncbi.nlm.nih.gov/18725385/
I'm not good at reading science...but seems to indicate a benefit to those with a SMAD3 mutation (which I have)
Not sure how common SMAD3 is as its not part of the normal genetic test panel. Might be worth a look for some.

I'm going to ask my Doc to prescribe Celebrex on my next visit.

Cheers
AT

Edited to add this more recent paper
'Smad3 mutant mice develop colon cancer with overexpression of COX‑2'
https://www.spandidos-publications.com/ ... .2017.5639
40 yo Male. BC Canada. Sigmoid Colectomy Dec. 2016
Pathology T3N2bM1 19 of 24 Nodes Positive + tumour deposits
PET scan - Para-Aortic and Iliac Lymph node spread. Stage VI.
Moderately differentiated. MSS. KRAS/BRAF Wild.
Mutations: TP53, ERBB4, MLL3, PDCD1LG2, PRKDC, SMAD3
FOLFOX Commenced Jan 9/2017 - Avastin(Bev) added after round 1.
June 2017 Dose Reduction on Round 11 due to Neuropathy.
Good PET Scan July 2017 - on maintenance 5FU/Bev every 2 weeks until progression.

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beach sunrise
Posts: 157
Joined: Thu Mar 05, 2020 7:14 pm

Re: ADAPT and Celebrex - What happened?

Postby beach sunrise » Sat Jul 25, 2020 10:54 pm

AT, good luck! I started on celebrex Thursday. I feel better already.
Dx 8/19, RC, CEA 86, clinical T3N0M0
Neoadj 5FU/rad 6 wks
Surg 1-21-20 APR ostomy, - margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24/post 5.9
Adj mFOLFOX6, cea 7
8 rds 6-10 CEA 11.4, 4 more no oxa
6-17: CEA 11.1 AFP 11.2 CA125 25.7 CA199 9
7-2: CEA 11.1 AFP 5.3 CA125 24.8 CA199 8
7-16: CEA 10.3 AFP 5.3 CA125 26.6 CA199 8
7-28 CEA 8.8 AFP 7.7 CA125 27 CA199 7
MHL1+
PMS2+
MSH2+
MSH6+
Chemo sensitivity test NCI "Test failed, neo-adj chemorad did its job. Not enough ca. cells to test."

hawkowl
Posts: 129
Joined: Sun Dec 14, 2014 5:29 am
Location: MN/FL

Re: ADAPT and Celebrex - What happened?

Postby hawkowl » Mon Jul 27, 2020 2:53 am

I_will_fight wrote:
Seems like Celecoxib increases heart risk, but I guess for most of us this is an acceptable risk.

JC


I have been on Celebrex 400 daily for more than five years. Initially with xeloda for maintenance and then just Celebrex. I have had a good oncological outcome (Stanley Scans for five years off chemo) but did develop rapid onset coronary artery disease and will be having a quadruple bypass this week. Not sure if u will continue the Celebrex
Dx 12/2014 T3N2MX (distant LPLN) low rectal
12/2014-4/2015: FOLFOX (8 cycles)
4/2015-6/2015: 28 cycles of chemoradiation with xeloda, SBRT
8/2015: Robotic APR with iliac node dissection; path showed ypT0,ypN0 (complete pathological response).
11/2015 scans clear, CEA 2.1
11/2015 parastomal hernia repair
3/2016 CEA 1.7, scans stable...
6/2020 5 years of normal CEA and stable scans
Now dealing with pyoderma gangrenosum.
Totally disabled due to oxaliplatin induced neuropathy and dysautonomia


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