My wife took celecoxib at 300-400 mg per day, with her daily chemo (and lots of carefully selected supplements), for over five years. Early in our chemo-supplements-celecoxib series, her markers rose but liver panels were good at 200 mg. At 300 mg her markers were stable or slightly depressed and liver markers very slightly affected; at 400 mg her markers improved but her liver panels had some rise. Over time we adjusted mostly UFT-LV loading and supplements for a better therapeutic index. After chemo she continued celecoxib for part of a year. She still does a fair amount of supplements e.g. IVC, big D, vit K2, beta glucans, resveratrol etc.
My wife started celecoxib at 2.8 years out from diagnosis to increase chemo's effect. Along the way she had 2-3 periods of hypercoagulability, that might be cancer, chemo and/or coxib related.
Stop? Damned if you do, damned if you don't - markers can rise and run.
Basically if she ran short on any category, chemo (UFT/5FU-LV), IV vitamin C, supplements, or celecoxib, her marker(s) would rise. So sometimes it became a juggling act to beat down coagulability and cancer markers, mostly by adjusting celecoxib and supplements several ways based on their various properties and case specifics.
She has been chemo free for two years now, after two surgeries and 8 years of chemo and 10 years of supplements. Careful, combined use of celecoxib, oral chemo, and substantial selected supplements worked for us.
watchful, active researcher and caregiver for stage IVb/c CC. surgeries 4/10 sigmoid etc & 5/11 para-aortic LN cluster; 8 yrs immuno-Chemo for mCRC; now no chemo
most of 2010 Life Extension recommendations and possibilities + more, some (much) higher, peaking ~2011-12, taper to almost nothing mid 2018, mostly IV C