ADAPT and Celebrex - What happened?

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Sophy
Posts: 250
Joined: Fri May 27, 2011 2:46 am
Location: New Zealand

Re: ADAPT and Celebrex - What happened?

Postby Sophy » Tue Oct 09, 2018 3:12 am

I am still on ADAPT and CT last week shows still NED since last surgery in August 2014.

I have a good quality of life and so will probably carry on with this. I take cimetedine as well.
dx T3N1M0 Feb 11 when children age 11, 7 and 2
Xeloda/rad March 11, LAR June 11 temp ileo
Xelox 6 rounds, NED
Lung mets Oct 13
Laser surgery Germany Jan 14. 3 mets left lung.
Laser surgery UK Jun and Aug 14 one met each lung, NED
Aug 14 Started Xeloda and Celebrex (ADAPT)
Oct 2018 CT shows still NED
Continuing ADAPT

Thedruid
Posts: 1
Joined: Tue Aug 21, 2018 1:49 pm
Facebook Username: theDruid

Re: ADAPT and Celebrex - What happened?

Postby Thedruid » Tue Oct 09, 2018 8:12 pm

Hello, StevieB

And what are the ususal side effects of such protocol ? The usual nausea caused by Xeloda only ?

Thanks!
_____________________________________
Diagnosed 07/16/18, age 43
Colon Resection 03/08/18,
Stage 3B colon cancer, T3N2aMO
Lymph-vascular invasion confirmed
6/16 lymph nodes
Port installed in 08/25/18
FOLFOX started in 08/29/18

Brearmstrong
Posts: 69
Joined: Sun Mar 26, 2017 3:24 pm
Location: CT

Re: ADAPT and Celebrex - What happened?

Postby Brearmstrong » Wed Oct 10, 2018 6:19 am

Good to hear that you are both doing well. StevieB, how did you get it approved? Where you part of a trial? Thanks!

-Brenda
45 F Jan 17 Mom 2 boys
tumor in appendix into colon
Muc Adeno 4cm
mod diff G2 T4aN2
nodes 8/50
CEA 4.6 after surgery < .05
KRAS G12D MSS
FOLFOX Apr-sep 17
Clean CT scan Jul 2017 lung nodule 4mm, clean CT oct 17, CEA 3.4, nov 17 CEA 8.1. May 18 2.3 Jul 18 1.0 oct 18 1.3
Oct 2017 clean CT
Nov 17 PET para aortic nodes uptake. Stage IV
Folfori w/avastin Dec 17 CEA 7.1
May 18- surgery to remove nodes- 5 positive. xeloda 2000mg/day
Aug 18-CT NED! Nov 18 CT clear, stay on Xeloda.

stevieb
Posts: 401
Joined: Sat Feb 09, 2013 12:26 am

Re: ADAPT and Celebrex - What happened?

Postby stevieb » Thu Oct 11, 2018 10:42 pm

I really don’t have much side effects. The only thing that I get is a stool that somewhat burns, almost like a virus, when on the Xeloda. Other than that, I feel pretty normal.

It was not part of a trial but I had my local onc call Dr Lin and get the protocol for me to follow and my onc at MDA neither approved nor disapproved of me adding the Celebrex. He finds it intriguing that I have no HFS and I keep telling him it is bc of the Celebrex!!
Dx age 33
12/19/12 Stage IV liver/lung
1/14-2/28/13 Folfox
3/27/13 rectal/lung rst; temp ileo
7/11/13 liver res/ileo rev
9/30/13 - Folfox
11/13,2/21 NED
3/14 lung recur;6/16-VATS
7/14 5 bi lung mets
10&11/15 laser lung surg
2015 Colondar Model
12/15 5 lung met-folfiri
5/15 NED
11/15 2 lung mets; cryoablation
1/4/17 2 lung mets; cryoablation
NED as of 1/23/17

User avatar
DBF
Posts: 304
Joined: Fri Jun 07, 2013 1:44 pm
Facebook Username: https://www.facebook.com/#!/profile.php?id=1000008
Location: New York

Re: ADAPT and Celebrex - What happened?

Postby DBF » Mon Oct 15, 2018 5:00 am

I was on the ADAPT protocol for three years. 2000 X/ 400 C. I never got HFS either- I never made the connection with the Celebrex! That’s very interesting.
I went off this past Memorial Day because I’d been NED for some time. I have a scan 11/8.

Best,
Donna
6/13 Dx @ 29 Wks pregnant, 42 yo
Adenocarcinoma, mucinous features
7/13 C-sec/col resec/part. hysterectomy
8/13 Pulm embolism
8/13 Liv met
9/13 Liv resect
FOLFOX
CEA UP
ADAPT: Xeloda/Celebrex
2/14 oopherectomy
10/15 obstruction surg
10/17 Scar tissue removal/vsg surg
NED :D
Mom to 3 boys: 20, 9 & 5

Brearmstrong
Posts: 69
Joined: Sun Mar 26, 2017 3:24 pm
Location: CT

Re: ADAPT and Celebrex - What happened?

Postby Brearmstrong » Mon Oct 15, 2018 12:31 pm

Thank you Donna and great news on being able to come off of adapt. I wish you NED forever!!! How did you get approval for it? Did you ask you oncologist or did they just put you on it? I'm taking 2000mg of xeloda a day but just not convinced it's doing enough to keep me NED.

Thanks!

-Brenda
45 F Jan 17 Mom 2 boys
tumor in appendix into colon
Muc Adeno 4cm
mod diff G2 T4aN2
nodes 8/50
CEA 4.6 after surgery < .05
KRAS G12D MSS
FOLFOX Apr-sep 17
Clean CT scan Jul 2017 lung nodule 4mm, clean CT oct 17, CEA 3.4, nov 17 CEA 8.1. May 18 2.3 Jul 18 1.0 oct 18 1.3
Oct 2017 clean CT
Nov 17 PET para aortic nodes uptake. Stage IV
Folfori w/avastin Dec 17 CEA 7.1
May 18- surgery to remove nodes- 5 positive. xeloda 2000mg/day
Aug 18-CT NED! Nov 18 CT clear, stay on Xeloda.


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