ADAPT and Celebrex - What happened?

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ElanF
Posts: 5
Joined: Mon Dec 05, 2016 9:07 am

ADAPT and Celebrex - What happened?

Postby ElanF » Fri Jul 28, 2017 1:17 pm

Several years ago there was a lot of excitement about the ADAPT protocol and using Celebrex to target stem cells. As far as I can tell the ADAPT study is now over, and no results have yet been published, and there's hasn't been much news about using this cocktail in a while.

Does anybody know what happened? Did the study fail? Were the other issues? Is anybody currently using Celebrex+Xeloda?

Thanks in advance.
Last edited by ElanF on Thu Aug 03, 2017 4:07 pm, edited 1 time in total.

Lee
Posts: 5293
Joined: Sun Apr 16, 2006 4:09 pm

Re: ADAPT and Celebrex - What happened?

Postby Lee » Tue Aug 01, 2017 5:57 pm

Don't have any real info, butt bumping this back to the top, sometimes thread get lost over the weekend.

Lee
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 10 years and counting!

lpas
Posts: 991
Joined: Wed Nov 19, 2014 11:11 pm

Re: ADAPT and Celebrex - What happened?

Postby lpas » Wed Aug 02, 2017 5:40 pm

Really good question. I don't have an answer to the piece about the study but I do know there were a number of people here doing the protocol. Pretty sure several of them are still on it. Check out the profiles for Sophy and DBF, both of whom are Stage IV and longer-term NED. I think Betsydoglover did it as well (but has now finished?). I've been taking the Celebrex part but not the Xeloda (any more).

Bottom line--I've been on this board several years and from what I've seen, a significant percentage of patients do very, very well on this protocol. I wouldn't let the lack of recent information deter you from pursuing it as an option. Hopefully someone else will chime in with more info. You might try PM'ing Maia. If anyone here knows, she probably would.
11/14 Dx sigmoid CC @ 45yo
12/14 Colectomy + hysterectomy
Stage IIIB, T3N1bM0, 2/20 nodes, MSS, G2, KRAS(A146T), TP53, SMAD4, ERBB2, CEA 1.0
2/15-7/15 XELOX, Celebrex & many supplements
3/16 Ovarian mass removed. Benign fibroid
9/16 clean colonoscopy
3/17 clean CT
Ongoing Celebrex, cimetidine & other carefully-targeted supplements
Post-chemo CEA 3.0, 2.5, 2.3, 2.0, 1.6, 1.3, 1.8, 2.1, 1.8, 2.0, 1.8, 1.9, 1.7, 1.5, 1.6, 1.5, 1.4, 1.4, 1.3, 1.3, 1.6, 1.6, 1.3
Mom to a 3 & 6yo

stevieb
Posts: 389
Joined: Sat Feb 09, 2013 12:26 am

Re: ADAPT and Celebrex - What happened?

Postby stevieb » Wed Aug 02, 2017 10:03 pm

I have been on it for about 6 months now also.
Dx age 33
12/19/12 Stage IV liver/lung
1/14-2/28/13 Folfox
3/27/13 rectal/lung rst; temp ileo
7/11/13 liver res/ileo rev
9/30/13 - Folfox
11/13,2/21 NED
3/14 lung recur;6/16-VATS
7/14 5 bi lung mets
10&11/15 laser lung surg
2015 Colondar Model
12/15 5 lung met-folfiri
5/15 NED
11/15 2 lung mets; cryoablation
1/4/17 2 lung mets; cryoablation
NED as of 1/23/17

ElanF
Posts: 5
Joined: Mon Dec 05, 2016 9:07 am

Re: ADAPT and Celebrex - What happened?

Postby ElanF » Thu Aug 03, 2017 4:04 pm

I emailed Dr. Lin directly to ask for his advice and guidance on taking the Xeloda/Celebrex combo. He did respond that he is traveling and will answer me when he has a chance. Will report back what he says. I just found it curious that the study seemed to have abruptly been suspended.

Lee
Posts: 5293
Joined: Sun Apr 16, 2006 4:09 pm

Re: ADAPT and Celebrex - What happened?

Postby Lee » Thu Aug 03, 2017 4:51 pm

WHOA :shock: don't know what happened here, butt I did not start this thread, just responded.

ElanF I believe you started this thread. Hopefully it will be corrected soon.

Lee
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 10 years and counting!

Achilles Torn
Posts: 89
Joined: Fri Dec 16, 2016 2:41 pm

Re: ADAPT and Celebrex - What happened?

Postby Achilles Torn » Thu Aug 03, 2017 11:12 pm

I'm interested as well. If I stay stable I'd like to consider ADAPT going forward. Please keep us in the loop when Dr. Lin responds.

Thanks
AT
40 yo Male. BC Canada. Sigmoid Colectomy Dec. 2016
Pathology T3N2bM1 19 of 24 Nodes Positive + tumour deposits
PET scan - Para-Aortic and Iliac Lymph node spread. Stage VI.
Moderately differentiated. MSS. KRAS/BRAF Wild.
Mutations: TP53, ERBB4, MLL3, PDCD1LG2, PRKDC, SMAD3
FOLFOX Commenced Jan 9/2017 - Avastin(Bev) added after round 1.
June 2017 Dose Reduction on Round 11 due to Neuropathy.
Good PET Scan July 2017 - on maintenance 5FU/Bev every 2 weeks until progression.

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Sophy
Posts: 235
Joined: Fri May 27, 2011 2:46 am
Location: New Zealand

Re: ADAPT and Celebrex - What happened?

Postby Sophy » Fri Aug 04, 2017 5:45 am

I have been on ADAPT protocol of 1000mg capecitabine and 200mg of celecoxib on a three week cycle since August 2014.

I started when I got home to New Zealand three weeks after my third lung laser thoracotomy surgery in Europe which made me to NED.

When I started this regime my oncologist in New Zealand contacted Dr Lin to ask him the dosage and duration. He replied that I should initially take for three years the dosage I am on.

All my scans have been clear since I started ADAPT.

I contacted Dr Lin by email a couple of months ago to ask him how the trial is going and that I am doing well on it and how long does he think I should keep taking the medications

He replied that he is very pleased to hear from me and glad I am doing so well but that is all he said and he hasn't replied to any more emails.

So my oncologist and the head oncologist and I all think that it will be safest for me to continue Adapt indefinitely until it stops working or something better comes along. I have already exceeded my oncologist's estimate of my life expectancy but she seems to be happy to be proved wrong.

Sophy
dx T3N1M0 Feb 11 when children age 11, 7 and 2
Xeloda/rad March 11, LAR June 11 temp ileo
Xelox 6 rounds, NED
Lung mets Oct 13
Laser surgery Germany Jan 14. 3 mets left lung.
Laser surgery UK Jun and Aug 14 one met each lung, NED
Aug 14 Started Xeloda and Celebrex (ADAPT)
Nov 2017 CT show still NED
Continuing ADAPT

ElanF
Posts: 5
Joined: Mon Dec 05, 2016 9:07 am

Re: ADAPT and Celebrex - What happened?

Postby ElanF » Tue Aug 08, 2017 7:19 pm

Dr Lin called me in response to my email. He didn't get into why the ADAPT study had been closed, but mentioned he is planning a new study. He still believes very much in the benefit of this cocktail.
Last edited by ElanF on Fri Aug 11, 2017 9:15 am, edited 1 time in total.

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Jack&KatiesMommy
Posts: 492
Joined: Wed Dec 21, 2011 1:08 pm
Location: Columbus, OH

Re: ADAPT and Celebrex - What happened?

Postby Jack&KatiesMommy » Thu Aug 10, 2017 3:42 pm

Sophy:
What is your exact protocol? My local oncologist is considering starting me on this program and we are collecting the different dosages that we have found people to be taking. You are on 1,000 mg of Xeloda once? a day and 200mg of celecoxib once? a day for a week and then off for 2 weeks. Thanks for sharing!
Cynthia
Cynthia
Mommy to Jack (8) now (14) and Katie (4) now (10)
(My Most Precious Things)
Dx 8/11 Stage IV CRC (liver mets) CEA 2,600+
9/11 Folfiri 2/12: Failed Liver Resection
5/12 HAI pump/removed primary
4/13 Liver Resection!
8/13; 10/13; 12/13; 3/14; 8/14; 11/14; 2/15; 7/15; 12/15 RFA lungs
5/17: Upper Left Lobe of lung removed in order to resect lymph nodes.
CEA: 1/16 2.5; 3/16 3.3; 5/16 2.8 7/16 3.8 4/17 53 7/17 4.1
NED for now.....

ElanF
Posts: 5
Joined: Mon Dec 05, 2016 9:07 am

Re: ADAPT and Celebrex - What happened?

Postby ElanF » Fri Aug 11, 2017 3:37 pm

Sophy wrote:I have been on ADAPT protocol of 1000mg capecitabine and 200mg of celecoxib on a three week cycle since August 2014.

I started when I got home to New Zealand three weeks after my third lung laser thoracotomy surgery in Europe which made me to NED.

When I started this regime my oncologist in New Zealand contacted Dr Lin to ask him the dosage and duration. He replied that I should initially take for three years the dosage I am on.

All my scans have been clear since I started ADAPT.

I contacted Dr Lin by email a couple of months ago to ask him how the trial is going and that I am doing well on it and how long does he think I should keep taking the medications

He replied that he is very pleased to hear from me and glad I am doing so well but that is all he said and he hasn't replied to any more emails.

So my oncologist and the head oncologist and I all think that it will be safest for me to continue Adapt indefinitely until it stops working or something better comes along. I have already exceeded my oncologist's estimate of my life expectancy but she seems to be happy to be proved wrong.

Sophy


Is it common for people who are NED to stay on chemo indefinitely? I've never heard of this before.

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Sophy
Posts: 235
Joined: Fri May 27, 2011 2:46 am
Location: New Zealand

Re: ADAPT and Celebrex - What happened?

Postby Sophy » Fri Aug 11, 2017 7:38 pm

Cynthia - so nice to see you are doing OK. I take 1000mg of xeloda morning and evening for two weeks then one week off then start again. I take 200mg celebrex morning and evening every day, no break. I also take 400mg cimetedine twice a day although this is not part of ADAPT. The xeloda dose is low compared to usual dosing but in order to tolerate it long term (50 rounds so far) the dose needs to be low. Hope this helps.

Elan - my oncologists think that it is likely I still have cancer cells but that they are being prevented from growing by the ADAPT. As my quality of life is good it seems unwise to take a break from chemo if I don't feel the need for it as then the mets would grow which would be very difficult/impossible to eradicate.

The usual reasons for a chemo break seem to be either the chemo is no longer working or the patient's health is suffering too much from side effects - and I am not in that situation at the moment.

Also, CEA and ca19-9 are not markers for me so it would only be when a met was big enough to see on a scan that it would be known about. My treatment is mostly paid for by the New Zealand public health system so I do not need an insurance company to approve it.

I am pleased you heard from Dr Lin, I too have been looking for updates on the ADAPT trial but not found anything recent. Would appreciate your posting if you get any information.
dx T3N1M0 Feb 11 when children age 11, 7 and 2
Xeloda/rad March 11, LAR June 11 temp ileo
Xelox 6 rounds, NED
Lung mets Oct 13
Laser surgery Germany Jan 14. 3 mets left lung.
Laser surgery UK Jun and Aug 14 one met each lung, NED
Aug 14 Started Xeloda and Celebrex (ADAPT)
Nov 2017 CT show still NED
Continuing ADAPT

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Jack&KatiesMommy
Posts: 492
Joined: Wed Dec 21, 2011 1:08 pm
Location: Columbus, OH

Re: ADAPT and Celebrex - What happened?

Postby Jack&KatiesMommy » Fri Aug 11, 2017 11:28 pm

Sophy:
So happy that you are continuing to do so well. (((HUGS))). Thank you! My hope is that you will be NED forever!
Cynthia
Cynthia
Mommy to Jack (8) now (14) and Katie (4) now (10)
(My Most Precious Things)
Dx 8/11 Stage IV CRC (liver mets) CEA 2,600+
9/11 Folfiri 2/12: Failed Liver Resection
5/12 HAI pump/removed primary
4/13 Liver Resection!
8/13; 10/13; 12/13; 3/14; 8/14; 11/14; 2/15; 7/15; 12/15 RFA lungs
5/17: Upper Left Lobe of lung removed in order to resect lymph nodes.
CEA: 1/16 2.5; 3/16 3.3; 5/16 2.8 7/16 3.8 4/17 53 7/17 4.1
NED for now.....


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