Rectal cancer (Stage 3A) diagnosed late June 2017

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Caat55
Posts: 515
Joined: Sat Dec 23, 2017 6:01 pm

Re: Rectal cancer (Stage 3A) diagnosed late June 2017

Postby Caat55 » Tue Feb 20, 2018 3:24 pm

heiders33 wrote:My blood pressure was pretty low in the weeks following LAR surgery. I was told to eat and drink salt and electrolytes. I’ve gotten my blood pressure back up to normal.

How are your hands?i see oncologist tomorrow to talk about mop up chemo. I am really concerned about sensory and functional changes to my hands .

Sussan
55 y.o. Female
Dx 9/26/17 RC Stage 3
Completed 33 rad. tx, xeolda 12/8/17
MRI and PET 1/18 sign. regression
Surgery 1/31/18 Ileostomy, clean margins, no lymph node involved
Port 3/1/2018
Oxaliplatin and Xeloda start 3/22/18
Last Oxaliplatin 7/5/18, 5 rounds

heiders33
Posts: 277
Joined: Sat Nov 04, 2017 11:08 am

Re: Rectal cancer (Stage 3A) diagnosed late June 2017

Postby heiders33 » Tue Feb 20, 2018 4:23 pm

My hands are fine. Sometimes I lose my grip and drop things, but I often wonder if I’ve always done that and just never noticed it until now. I don’t have any numbness or tingling. My feet are still recovering - they get red and angry and blistery and occasionally tingly if I stress them too much. I live in NYC so I walk a lot. I’ve been wearing thick socks which helps, but now the weather is getting warm this week so we’ll see. I got an oncology massage last night which focused on my hands and feet. It was so nice.
36 year-old female
May 2017: Dx rectal cancer at T3N2M0
MSS, KRAS
June-July 2017: 28 days of chemo/radiation
September 2017: laparoscopic LAR surgery with loop ileostomy
October 2017 - February 2018: XELOX six rounds
March 2018: reversal
April 2018: CEA 2.1, all blood counts normal
May 2018: CT scan showed liver spot
August 2018: Abnormal PET, CEA 2.4
September 2018: liver resection with HAI pump

NHMike
Posts: 1700
Joined: Fri Jul 21, 2017 3:43 am

Re: Rectal cancer (Stage 3A) diagnosed late June 2017

Postby NHMike » Fri Feb 23, 2018 6:23 am

heiders33 wrote:My hands are fine. Sometimes I lose my grip and drop things, but I often wonder if I’ve always done that and just never noticed it until now. I don’t have any numbness or tingling. My feet are still recovering - they get red and angry and blistery and occasionally tingly if I stress them too much. I live in NYC so I walk a lot. I’ve been wearing thick socks which helps, but now the weather is getting warm this week so we’ll see. I got an oncology massage last night which focused on my hands and feet. It was so nice.


It's been so nice and then we got snow yesterday and some of the cold sensitivity came back (on my nose). The Xeloda is definitely affecting my hands (arthritic feeling) as it doesn't fade like the other Oxaliplatin stuff. I'll talk to the Oncologist about that.

Change the bag yesterday morning - 7.5 days on it and it was starting to sting. The bag change took 14 minutes which is quick for me. I'm still loving the Convex bags. I don't mean to wait so long between bag changes but life has been busy (work especially). The snow should melt quickly as I think that it's 40s today and 50s tomorrow. I'm getting more sleep at night and doing more of the big-four barbell exercises daily (deadlifts, squats, military press, bench press). Also trying to stretch more but it's tough to fit it all in.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal

NHMike
Posts: 1700
Joined: Fri Jul 21, 2017 3:43 am

Re: Rectal cancer (Stage 3A) diagnosed late June 2017

Postby NHMike » Sun Feb 25, 2018 8:29 pm

I've been getting in a bit more exercise, both in the form of formal workouts and in doing more physical chores. It will end, of course, on infusion day this week. I'm considering asking for a drop to 75% from 80%. I am having regular arthritic feeling in my hands when I wake up and much less during the day. The latter is due to the Xeloda as it stayed consistent and didn't fade. So I'm keeping on and getting used to the cycles and dreading the infusion days.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal

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Atoq
Posts: 306
Joined: Wed Oct 25, 2017 9:31 am

Re: Rectal cancer (Stage 3A) diagnosed late June 2017

Postby Atoq » Mon Feb 26, 2018 8:05 am

How many rounds do you still have to do? How big is the Xeloda dose compared to the one you took during radiotherapy?

Claudia
45 year old, mother of 2
Dx rectal cancer October 2017
At least T3N2aMX (suspect metastasis to one lung 8 mm)
Lynch negative
CEA 1.8
Neoadjuvant chemoradiotherapy Xeloda + 25x2 Gy
05.12.17 laparotomic surgery for blockage, colostomy
25.01.18 laparotomic lar, hysterectomy, ileostomy
05.03.18 core needle biopsy of lung, updated to stage IV
07.05.18 CAT scan, lung metastasis 11 mm
04.06.18 ileostomy reversal
26.06.18 wedge VATS surgery
24.08.18 CAT scan, clear
12.09.18 scope, ok. CEA 1.6

NHMike
Posts: 1700
Joined: Fri Jul 21, 2017 3:43 am

Re: Rectal cancer (Stage 3A) diagnosed late June 2017

Postby NHMike » Mon Feb 26, 2018 11:14 am

Atoq wrote:How many rounds do you still have to do? How big is the Xeloda dose compared to the one you took during radiotherapy?

Claudia


Another five rounds to go.

The Xeloda for Adjuvant is 4,000 units (mg I assume). The Neo-Adjuvant was 3,500. I also had weekends off on Neo-Adjuvant. That additional 500 mg makes a difference.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal

heiders33
Posts: 277
Joined: Sat Nov 04, 2017 11:08 am

Re: Rectal cancer (Stage 3A) diagnosed late June 2017

Postby heiders33 » Mon Feb 26, 2018 11:35 am

Mike, you and I had similar staging, I think, and I did six rounds of Xelox and it looks like you are doing eight. Have you talked to your onc about reducing it to six? My onc kept it at six because he wanted to maximize impact while minimizing side effects. I know eight is listed as the standard, but it seems like the standards are changing. Of course your onc knows things I don’t know, but just a suggestion.
36 year-old female
May 2017: Dx rectal cancer at T3N2M0
MSS, KRAS
June-July 2017: 28 days of chemo/radiation
September 2017: laparoscopic LAR surgery with loop ileostomy
October 2017 - February 2018: XELOX six rounds
March 2018: reversal
April 2018: CEA 2.1, all blood counts normal
May 2018: CT scan showed liver spot
August 2018: Abnormal PET, CEA 2.4
September 2018: liver resection with HAI pump

NHMike
Posts: 1700
Joined: Fri Jul 21, 2017 3:43 am

Re: Rectal cancer (Stage 3A) diagnosed late June 2017

Postby NHMike » Mon Feb 26, 2018 11:48 am

heiders33 wrote:Mike, you and I had similar staging, I think, and I did six rounds of Xelox and it looks like you are doing eight. Have you talked to your onc about reducing it to six? My onc kept it at six because he wanted to maximize impact while minimizing side effects. I know eight is listed as the standard, but it seems like the standards are changing. Of course your onc knows things I don’t know, but just a suggestion.


My second opinion at Dana Farber said "Minimum four, Maximum eight, Sweet Spot six". I haven't worried about it but I'll crank up the research after #4. Yes, I'm aware of the research but it's so much effort just getting close to those numbers.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal

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ocstacy
Posts: 262
Joined: Mon Jun 19, 2017 11:29 pm
Facebook Username: stacy

Re: Rectal cancer (Stage 3A) diagnosed late June 2017

Postby ocstacy » Mon Feb 26, 2018 2:08 pm

Took my nap and it is still awful. This is going to be tough until it starts to subside. Going back to sleep some more with gloves.


Been thinking about you. How is everything? My mom and you were doing everything at the same time. My mom had tough recovery. She is now just on Xeloda, you? Hope all is okay. There are a lot of ups and downs with this process. My mom's last day of chemo is May 3, than reversal is set for a month or two after that. Have a great day!


Stacy
Caregiver/daughter to dear mother age 78, dx 5/09/17 because of me!! :wink:
Rectal CA Stage 3 low-grade adenocarcinoma- 6 cm
Neoadjuvant start 7/10/17 ended 08/16/17
3D Lap. surgery @ Keck USC, Dr. Sang Lee 10/17/17 temp ileostomy
11/1 hospitalized abscess/hernia - back home 11/06/17 antibiotics
NO LYMPHS INVOLVED! NEAR PATHOLOGICAL RESPONSE! YAY! :shock:
Took her last chemo med 05/10/18! Ileostomy reversal 07/24/18
First BM after reversal 07/25/18
Me: 1st Colonoscopy age 38. 08/17 Benign polp.

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susie0915
Posts: 840
Joined: Wed Aug 02, 2017 8:17 am
Facebook Username: Susan DeGrazia Hostetter
Location: Michigan

Re: Rectal cancer (Stage 3A) diagnosed late June 2017

Postby susie0915 » Mon Feb 26, 2018 2:36 pm

My oncologist told me a total of 8 rounds but included the chemo I had during preadjuvant therapy as one round. So she scheduled me for 7 more after surgery. I ended up doing 6 which she was fine with because my son was getting married out of town and I wanted a month to recover if possible. Depending how you do during the next rounds I'm sure your oncologist with re-evaluate what is necessary.
58 yrs old Dx @ 55
5/15 DX T3N0MO
6/15 5 wks chemo/rad
7/15 sigmoid/scar tissue left
8/15 Pet scan NED
9/15 LAR
0/24 nodes
10/15 Bowel blockage. surgery,early ileo rev, c-diff inf :(
12/15 6 rds of xelox
5/16 Clear CT lung scarring/inflammation
9/16 clear colonoscopy
4/17 CT 4mm lung nod
7/17 no change lung nod
10/17 Clear pel/abd CT
11/17 CEA<.5
1/18 CT/Lung no change in 4mm nodule
5/18 CEA<.5, clear CT pel/abd/lung nod no change

Caat55
Posts: 515
Joined: Sat Dec 23, 2017 6:01 pm

Re: Rectal cancer (Stage 3A) diagnosed late June 2017

Postby Caat55 » Mon Feb 26, 2018 5:50 pm

The Xeloda for Adjuvant is 4,000 units (mg I assume). The Neo-Adjuvant was 3,500. I also had weekends off on Neo-Adjuvant. That additional 500 mg makes a difference.[/quote]

Mike,
What do you mean the additional 500 mg makes a difference? In what way?
I have decided to go with the oral Xeloda, after hearing the process with the 5 FU. Longer time at infusion center, more frequent visits, idea of being hooked up to a bottle of chemo for two additional days.

Susan
55 y.o. Female
Dx 9/26/17 RC Stage 3
Completed 33 rad. tx, xeolda 12/8/17
MRI and PET 1/18 sign. regression
Surgery 1/31/18 Ileostomy, clean margins, no lymph node involved
Port 3/1/2018
Oxaliplatin and Xeloda start 3/22/18
Last Oxaliplatin 7/5/18, 5 rounds

User avatar
Atoq
Posts: 306
Joined: Wed Oct 25, 2017 9:31 am

Re: Rectal cancer (Stage 3A) diagnosed late June 2017

Postby Atoq » Tue Feb 27, 2018 11:46 am

I think he means that even if it is only 12.5% more than the neoadjuvant dose, the side effects are much stronger.

Claudia
45 year old, mother of 2
Dx rectal cancer October 2017
At least T3N2aMX (suspect metastasis to one lung 8 mm)
Lynch negative
CEA 1.8
Neoadjuvant chemoradiotherapy Xeloda + 25x2 Gy
05.12.17 laparotomic surgery for blockage, colostomy
25.01.18 laparotomic lar, hysterectomy, ileostomy
05.03.18 core needle biopsy of lung, updated to stage IV
07.05.18 CAT scan, lung metastasis 11 mm
04.06.18 ileostomy reversal
26.06.18 wedge VATS surgery
24.08.18 CAT scan, clear
12.09.18 scope, ok. CEA 1.6

NHMike
Posts: 1700
Joined: Fri Jul 21, 2017 3:43 am

Re: Rectal cancer (Stage 3A) diagnosed late June 2017

Postby NHMike » Tue Feb 27, 2018 5:25 pm

ocstacy wrote:
Took my nap and it is still awful. This is going to be tough until it starts to subside. Going back to sleep some more with gloves.


Been thinking about you. How is everything? My mom and you were doing everything at the same time. My mom had tough recovery. She is now just on Xeloda, you? Hope all is okay. There are a lot of ups and downs with this process. My mom's last day of chemo is May 3, than reversal is set for a month or two after that. Have a great day!

Stacy


Really busy with work and taking care of chores before the infusion tomorrow. I like to get a lot of odds and ends done on my off week as I'm a wreck the other two.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal

NHMike
Posts: 1700
Joined: Fri Jul 21, 2017 3:43 am

Re: Rectal cancer (Stage 3A) diagnosed late June 2017

Postby NHMike » Tue Feb 27, 2018 5:28 pm

Caat55 wrote:The Xeloda for Adjuvant is 4,000 units (mg I assume). The Neo-Adjuvant was 3,500. I also had weekends off on Neo-Adjuvant. That additional 500 mg makes a difference.


Mike,
What do you mean the additional 500 mg makes a difference? In what way?
I have decided to go with the oral Xeloda, after hearing the process with the 5 FU. Longer time at infusion center, more frequent visits, idea of being hooked up to a bottle of chemo for two additional days.

Susan[/quote]

There's a video of me playing tennis on YouTube on the next to last day of Xeloda and Radiation. You wouldn't think that I was on chemo or radiation in watching the video. I have arthritic feelings in my hands right now that I think are from the Xeloda and I'm guessing that it's the hands and feet syndrome that people talk about. I know what osteoarthritis feels like because I've had it in my knees in the past. Fortunately, shoe technology has improved so that it's much less of a problem now. So I will talk about dropping the dose on the Xeloda with the oncologist tomorrow. I only have 500 MG pills but we could go with 4 in the morning and 3 in the evening for 3,500.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal

NHMike
Posts: 1700
Joined: Fri Jul 21, 2017 3:43 am

Re: Rectal cancer (Stage 3A) diagnosed late June 2017

Postby NHMike » Tue Feb 27, 2018 7:48 pm

Got a lot done today in preparation for the infusion tomorrow. I also changed the bag in a record 7 minutes. Recommendation: do your bag changes the day before the infusion as you'll feel less like doing it in the couple of days afterwards. I can't believe how much work there is to do - fortunately there isn't any schedule pressure in the near future but I sometimes put pressure on myself to get things done.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal


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