Anyone on XELOX and working?

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AJQ
Posts: 6
Joined: Sun Jul 16, 2017 9:29 am
Facebook Username: Amjadqur1

Anyone on XELOX and working?

Postby AJQ » Sun Jul 16, 2017 9:59 am

Hi
I am new to this forum and been recently diagnosed of stage 3 appendix/CC. Had right hemicolectomy almost 4 weeks ago and now starting Xelox( Oxaliplatin + Xeloda pills) soon. I must work! Any experience and how to manage with Xelox and weather I can keep working office job full time.
Appreciate it.

AJ
52 yr, stage III adenocarcinoma of appendix and Cecum
LAP Appendix Removal 5/16/17
Diagnosed on 5/22/17
CEA 6/8/17: 1.0
LAP RHC: 6/21/17, 1/21 positive Lymph. T4N1M0
7/27: starting Xelox
Next Full CT: 7/21/17

Aqx99
Posts: 62
Joined: Fri Mar 31, 2017 7:28 am
Location: Pfafftown, NC

Re: Anyone on XELOX and working?

Postby Aqx99 » Sun Jul 16, 2017 10:51 am

I'm about to start the same chemo as you. My oncologist said I would need a couple of days after each infusion to recover from the worst of it. I would suggest trying to schedule your infusions so you can make the most of your weekend for recovery. I work a rotating shift and always have Tuesday and Wednesday off, so she scheduled me for infusions on Monday.
Female, 39
Stage IIIB Rectal Cancer
T3N1M0
Diagnosed at age 39
2/21/17 diagnosis
3/23/17 - 5/2/17 Chemoradiation, 28 treatments
6/14/17 Robotic LAR with temp loop ileostomy, ovaries and fallopian tubes removed, 2/21 lymph nodes positive
7/24/17 Starting CapOx
CEA at diagnosis 0.9

AJQ
Posts: 6
Joined: Sun Jul 16, 2017 9:29 am
Facebook Username: Amjadqur1

Re: Anyone on XELOX and working?

Postby AJQ » Sun Jul 16, 2017 11:20 am

Thankx aqx99!
I chose thursdays for my infusions and hope to go to work on mondays.
52 yr, stage III adenocarcinoma of appendix and Cecum
LAP Appendix Removal 5/16/17
Diagnosed on 5/22/17
CEA 6/8/17: 1.0
LAP RHC: 6/21/17, 1/21 positive Lymph. T4N1M0
7/27: starting Xelox
Next Full CT: 7/21/17

Basil
Posts: 47
Joined: Thu Mar 16, 2017 12:33 pm

Re: Anyone on XELOX and working?

Postby Basil » Sun Jul 16, 2017 12:44 pm

I worked through six rounds of FOLFOX. Missed a day here and there. Some cycles were just worse than the others. I'd get infusions on Wednesday and would feel pretty good Thursday and Friday, then feel crappy Saturday and Sunday. Could usually drag into work Monday and on the mend after that. Gotta admit, though, I spent a lot of time staring at my computer and not doing any actual work.
40 y/o male, kids 6&9
Dx 3/16/17, rectal cancer S3a,t2,n1,m0
Prospect trial (FOLFOX in lieu of rad pre-resection)
FOLFOX started 4/5/17
7/14 scans show 80% regression, no mets
Resection scheduled 7/31
Lynch negative

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horizon
Posts: 1394
Joined: Tue Apr 12, 2011 10:10 pm

Re: Anyone on XELOX and working?

Postby horizon » Mon Jul 17, 2017 12:02 pm

Everyone reacts differently, but for me I didn't miss an unplanned day of work through 6 months of XELOX. Took Wed off for an infusion and worked from home Thur and Fri. Monday I was back at work and the gym.
I'm just a dude who still can't believe he had a resection and went through chemo (currently 6 years NED). Is this real life?

[Ana & Alex]
Posts: 58
Joined: Tue Feb 14, 2017 5:14 pm
Location: Austria

Re: Anyone on XELOX and working?

Postby [Ana & Alex] » Mon Jul 17, 2017 4:18 pm

I'm on Xelox as well but unfortunately I cannot share the positive experiences described on this thread :|

After my two cycles I was admited in the hospital and was bed ridden for a week with massive nausea, uncontrolled shivering, fatigue, constipation and neuropathy. After day 10 I started cooking again and dong some house chores and playing with my daughter. I'm currently in my week off chemo and still have nausea.

I'm reducing the dosis to 80% next time around and I'm hoping that I too, will be able to spend the first few days resting and then have a taste of normal life and go back to Work again.

It was been difficult to figure what works for me, I've tried multiple drugs only with limited effect. This time around we're intreducing Dronabinol for nausea control, trying new laxatives and hoping for the best.

Staying on top of side effects and learning how to counteract them has been the greater challenge and the fact that I seem to metabolize oxaliplatin really slow and end up with a higher dosis of the drug in my body longer than planned.

I hope that you too, can maintain a normal life and work, as many people in this forum. And im hoping to join you soon as well.

All the best and good luck,
Ana
29 yo. Mum (21 Mo) & Wife

12/2016: Dx Rectum AdenoCa G2 4 cm ab ano. CEA 4.3
01/2017: RAS Wildtyp. MSS. IIIB.
01 - 03/2017: 28 RTx + CHT 2500 mg/d Capecitabine
03 - 06/2017: Suplemments and Cimetidine.
05/2017: TME/TAMIS + permanent Colostomy CEA 0.5
05/2017: ypT2N2aM0 (4/15), limited response to RTx
06 - 11/2017: 7 x CapOx w/ 230mg + 3500 mg/d (5 to go)

AJQ
Posts: 6
Joined: Sun Jul 16, 2017 9:29 am
Facebook Username: Amjadqur1

Re: Anyone on XELOX and working?

Postby AJQ » Mon Jul 17, 2017 5:30 pm

Thank you Ana and all for your replies. I really
Appreciate them. Going for CT scan this Friday and then first Chemo doze next week. Will keep you all posted

All the best.

AJ
52 yr, stage III adenocarcinoma of appendix and Cecum
LAP Appendix Removal 5/16/17
Diagnosed on 5/22/17
CEA 6/8/17: 1.0
LAP RHC: 6/21/17, 1/21 positive Lymph. T4N1M0
7/27: starting Xelox
Next Full CT: 7/21/17

Brearmstrong
Posts: 10
Joined: Sun Mar 26, 2017 3:24 pm
Location: CT

Re: Anyone on XELOX and working?

Postby Brearmstrong » Mon Jul 17, 2017 7:36 pm

AJ, while I am going through 12 rounds folfox, I am still working full time but take Friday off as that is the day after pump is removed and I am down and out for at least 48 hours. Reason I am replying though is that our diagnosis is similar with exception of me having 8 positive nodes. Wanted to say hi and let's keep in touch as time goes by. Appendix cancer can be a different beast but hoping mine doesn't spread through peritoneal mets as that makes treatment more difficult. I wish you all the best with your scan!!
Brenda
45 Female Jan 2017 after appendectomy
DX: (CC) tumor started in appendix and went through colon wall
Adenocarcinoma w/ mucinous features 4.1cm
mod diff G2 T4aN2
Stage IIIC
nodes 8/50
CEA 4.6 after surgery < .05
margins clear
No mutations- just bad luck- marathon runner, clean diet, non smoker, no family history
Lap hemi
FOLFOX started April 2017 but reduced both agents after round 2, crashing WBC even with nuelasta shots. Clean CT scan July 2017 watching one small lung nodule

AJQ
Posts: 6
Joined: Sun Jul 16, 2017 9:29 am
Facebook Username: Amjadqur1

Re: Anyone on XELOX and working?

Postby AJQ » Mon Jul 17, 2017 10:51 pm

Brenda,
Thanks for your reply. Appendix cancer is rare and can be very aggressive and unpredictable. Let's stay in touch. You can PM me and I give you my email address.

AJ
52 yr, stage III adenocarcinoma of appendix and Cecum
LAP Appendix Removal 5/16/17
Diagnosed on 5/22/17
CEA 6/8/17: 1.0
LAP RHC: 6/21/17, 1/21 positive Lymph. T4N1M0
7/27: starting Xelox
Next Full CT: 7/21/17

mpbser
Posts: 184
Joined: Wed Apr 19, 2017 11:52 am

Re: Anyone on XELOX and working?

Postby mpbser » Wed Jul 19, 2017 5:08 am

A little off topic: How often do you get your ox- infusions? My husband's oncologist says 1x every 2 weeks but the NCCN guidelines say every 3 weeks. More specifically, this is what it says:

CAPEOX
Oxalplatin 130 mg/m2 IV day 1
Capecitabine 1000+- mg/m2 twice daily PO for 14 days
Repeat every 3 weeks
Wife of 4/12/17 Dx age 45
5/19/17 - Lap left hemi
Adenocarcinoma
Tumor size: 5 x 4 x 1 cm
low grade
T3 N2b M1a
Stage IV A
lymph nodes: 9 of 54
CEA: 1.4 Pre-op; 2.1 2 days Post-op
Tumor extension: Invasive through muscularis propria into pericolic fat
Proximal margin: >14 cm Distal margin: >14 cm Mesenteric margin: 3 cm
Lymphovascular invasion present
MSS/MSI-L
Lynch - unlikely; KRAS wild
Immunohistochemsistry: Normal expression of MLH1, MSH2, MSH6, and PMS2

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LeonW
Posts: 280
Joined: Sun May 03, 2015 4:59 pm
Location: Amsterdam, Netherlands

Re: Anyone on XELOX and working?

Postby LeonW » Wed Jul 19, 2017 8:47 am

My infusions were all day sessions on Thursdays. Was pretty sick on Fridays/Saturdays but much better the Sunday. Then gradually better each day the folowing week and almost normal during week-3. Everyone reacts differently, but I was glad I just had retired before everything started.

Your planned schedule (chemo on Thursday - resume work on Monday) makes sense.
I hope you'll do better than I did; give it try and keep day-to-day record how you feel. Once it's predictable it feels *much* better.

Bets wishes, Leon
Dec 2012 - Dx CC; MM @ 65yrs, 2 unresect liver mets, CEA 41.8
Jan 2013 - colectomy @ spleen (IVa T3N1bM1a) 2/26 nodes, MSI-low
Feb-Aug - 1x Xelox-7x Xelox/Avastin, mets shrink from #3
Sept - 2x failed Portal Vein embolization
Oct 2013 - R liver resect 28 hosp days (liver failure, delirium, emboli, encephalopathy) Pathology: no cancer cells pCR (ypT0N0M0)
2014/15 - recovery; benign polyp Apr '15
Apr 2016 new house/town/life
clean CTs and 1.3/1.4 CEAs: 4x2014, 4x2015/16, May2017; next Nov 2017

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horizon
Posts: 1394
Joined: Tue Apr 12, 2011 10:10 pm

Re: Anyone on XELOX and working?

Postby horizon » Wed Jul 19, 2017 8:50 am

mpbser wrote:A little off topic: How often do you get your ox- infusions? My husband's oncologist says 1x every 2 weeks but the NCCN guidelines say every 3 weeks. More specifically, this is what it says:

CAPEOX
Oxalplatin 130 mg/m2 IV day 1
Capecitabine 1000+- mg/m2 twice daily PO for 14 days
Repeat every 3 weeks


If you go the Xeloda (Capecitabine) and Oxi route that's how it works. If you go with FOLFOX you wear a pump for a period of time and then repeat in less than three weeks. For me personally I loved the third week where there was nothing to do. No pills and no infusions. I always called that my mini chemo vacation.
I'm just a dude who still can't believe he had a resection and went through chemo (currently 6 years NED). Is this real life?

mozart13
Posts: 48
Joined: Fri Dec 09, 2016 7:38 pm
Location: Toronto

Re: Anyone on XELOX and working?

Postby mozart13 » Wed Jul 19, 2017 11:03 am

mpbser wrote:A little off topic: How often do you get your ox- infusions? My husband's oncologist says 1x every 2 weeks but the NCCN guidelines say every 3 weeks.


My understanding is every 2 weeks if considered curable, they tend be more agresive in that case.
55 year, male, never been seek in my life.
Diagnosed with T1,T2 N0 M0 rectal cancer, tumor 4.5cm,
Stage 1
CEA 2.0
Discovered by pure lack, after taking baby ASA, had blood in stool.
25 sessions of Xeloda 1750 twice a day and Radiation 50 gy finished end of January 2017
Tumor erased, CCR, negative mri, ct, scope, just scar left, no evidence of cancer
W&W approach 8)
April 2017, started folfox 10 rounds, every second week

User avatar
horizon
Posts: 1394
Joined: Tue Apr 12, 2011 10:10 pm

Re: Anyone on XELOX and working?

Postby horizon » Wed Jul 19, 2017 11:32 am

mozart13 wrote:
mpbser wrote:My understanding is every 2 weeks if considered curable, they tend be more agresive in that case.


I was given a choice of every two weeks with the pump and FOLFOX or every three weeks with XELOX. The stated goal was always a cure for my case.
I'm just a dude who still can't believe he had a resection and went through chemo (currently 6 years NED). Is this real life?

mpbser
Posts: 184
Joined: Wed Apr 19, 2017 11:52 am

Re: Anyone on XELOX and working?

Postby mpbser » Wed Jul 19, 2017 11:51 am

Thanks for the input re: Ox timing for XELOX/CAPEOX protocols. It's good information to have at this point in time for us, so much appreciated.
Wife of 4/12/17 Dx age 45
5/19/17 - Lap left hemi
Adenocarcinoma
Tumor size: 5 x 4 x 1 cm
low grade
T3 N2b M1a
Stage IV A
lymph nodes: 9 of 54
CEA: 1.4 Pre-op; 2.1 2 days Post-op
Tumor extension: Invasive through muscularis propria into pericolic fat
Proximal margin: >14 cm Distal margin: >14 cm Mesenteric margin: 3 cm
Lymphovascular invasion present
MSS/MSI-L
Lynch - unlikely; KRAS wild
Immunohistochemsistry: Normal expression of MLH1, MSH2, MSH6, and PMS2


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