The Colon Club

I've seen this mentioned many times on this board. What is it? Is it only through Dr. Lin?

Thanks!

There are quite a few posts by Maia about this if you want to look them up, she has many links to information about it and I have posted about it too, but Maia is the most knowledgeable.

Basically it is a trial combining low dose capecitabine (oral 5fu, also called xeloda) with celecoxib, an arthritis painkiller. It is testing whether the addition of celecoxib to capecitabine both enhances the tumour destroying effect of the chemo whilst also decreasing the side effects.

It seems to work best on very low tumour burden, and it doesn't work for everyone, members here have had progression on it and later died. I started it in August 2014 after 3 lung laser surgeries in Europe removing all visible mets. All my scans have been clear since then.

As my tumours have never been detectable with blood markers CEA or CA19-9 my oncologist says there is no way to know if I have new mets growing before they are large enough to see on CT - about 5mm.

So, as my quality of life is very good on ADAPT, my oncologist and I agree that I should not risk stopping ADAPT and then having tumour growth which could not be controlled - so I will continue to take it indefinitely until we have more information from the ADAPT trial and other trials like immunotherapy which could give a better chance of a cure and not just a disease control.

Hope that this helps

Sophy

Thanks Sophy! DH has low Tumor burden. Few mets to lungs that are tiny. I think four or five right now. I suggested laser lung surgery to the oncologist and she didn't see the point of it. She said they can RFA them as they become an issue. They did RFA to one six weeks ago that worked well.

Why did you go to Germany? Wasn't that your choice or oncologists? Do we just reach out to DR. Lin ourselves?

I took Celebrex 400 mg daily throughout FOLFOX and chemoradiation and had a good response. Although I have not been on chemo since 2015 I remain on Celebrex and plan to do so indefinitely

Although our experience is with a different oral 5FU drug, UFT instead of xeloda, and other ingredients, 300-400 mg of daily celecoxib (like ADAPT) is now a crucial ingredient.

Our experience was that cimetidine for KRAS/CA19-9 related metastasis and even more stuff, mostly powerful supplements (ones with real anti-cancer literature) are necessary to keep mets and markers low, or drive them back down. We actually target some of "the extras" and grade performance, based on markers and blood panels. You do need some kind of medical support. For us, our alternative MD who dislikes chemo, is our principal advisor and fields most of our questions, naturally. Once there is a mild but effective system in place, the constant medical crisis may disappear.

Oral chemo has more flexibility since you do the actual administration but you need prescriptions for xeloda and celecoxib (usually, maybe not some places overseas). We have found stockpiling a crucial element of survival in an avaricious, glitch based supply system, where shortages and artificial scarcities are recurring features.

So although I think Dr Lin's ADAPT protocol alone sounds like a good start with many great results, more ingredients might be necessary for best results individually. For us, this certainly beats Folfiri or Folfox, on longevity, quality of life, and costs.