Although our experience is with a different oral 5FU drug, UFT instead of xeloda, and other ingredients, 300-400 mg of daily celecoxib (like ADAPT) is now a crucial ingredient.
Our experience was that cimetidine for KRAS/CA19-9 related metastasis and even more stuff, mostly powerful supplements (ones with real anti-cancer literature) are necessary to keep mets and markers low, or drive them back down. We actually target some of "the extras" and grade performance, based on markers and blood panels. You do need some kind of medical support. For us, our alternative MD who dislikes chemo, is our principal advisor and fields most of our questions, naturally. Once there is a mild but effective system in place, the constant medical crisis may disappear.
Oral chemo has more flexibility since you do the actual administration but you need prescriptions for xeloda and celecoxib (usually, maybe not some places overseas). We have found stockpiling a crucial element of survival in an avaricious, glitch based supply system, where shortages and artificial scarcities are recurring features.
So although I think Dr Lin's ADAPT protocol alone sounds like a good start with many great results, more ingredients might be necessary for best results individually. For us, this certainly beats Folfiri or Folfox, on longevity, quality of life, and costs.
watchful, active caregiver for stage IVb CC since early 2010. immuno"Chemo forever," for mCRC