The Colon Club

Hi Everyone,

I wrote up a blog about ASCO 2017. Post it was a bit delayed due to some medical adventures on my end........

"THE BEST MSS COLORECTAL CANCER TALK AND CLINICAL TRIAL AT ASCO 2017"

https://adventuresinlivingterminallyopt ... asco-2017/

Cheers,
-DK

Have not read all of it yet, butt I plan to.

Hope your doing okay,

Lee

This is exciting! Great easy to understand blog post DK! Thank you!

In his Blog post DK37 wrote:
"Q. Many CRC patients have low CEA measurements in their blood tests, can RO6958688 work in those patients? ...
A. There is not a direct correlation between the amount of CEA expressed by a patient’s tumors and CEA in that patient’s bloodstream (ref. https://www.ncbi.nlm.nih.gov/m/pubmed/9378556/ )
– so yes, the drug should be able to work even if a patient has low blood CEA levels. Oftentimes a tumor expresses a lot of CEA – it just isn’t released into the blood allowing it to be measured by the standard CEA blood test!"

Thank You very much DK for info about this Clinical Trial and for explaining this (quoted) about CEA!

Wishing you well !
Kind Regards /LPL

As always buddy ... adding immensely to all our experiences here
by sharing all of your own !

JMO .... BUTT ... I would be good in wishing maybe you didn't need to have so many experiences ....
if you know what I mean !!!

Cheers and Harmony bro'
CRguy

Very interesting writeup on this new development Tom. I noticed you did the SIRT procedure on June 1. Did you do both lobes at the same time or stagger them? SIRT has a special significance to me as I would have had it done for my mother if we had been aware early enough. I believe in my heart it would have helped her metastatic tumors which were confined solely to her liver.

How was the procedure and recovery? I read it sometimes takes quite a while for results to show on CT scans. Hope you are feeling better. I have read that sometimes SIRT can dramatically improve how you feel if your liver tumors are symptomatic/ causing weakness.

Josh

Definitely a positive development to see this kind of approach having an impact on MSS disease, although I worry a bit about the durability issue. I was so excited to see that JulieYW made it into this trial but it seems (from her blog) that the results were extremely short-lived.

Thanks as always for keeping us updated! So glad to hear the SIRT and the radiation have brought you some relief.

Always so glad to read your updates, both the medical ones and the personal ones. Rooting for more normal days!

If the Lovenox is a big bummer, I was put on Edoxaban a year ago as part of the trial linked below. It cleared up my PE and I haven't had any side effects from the medicine.

https://clinicaltrials.gov/ct2/show/NCT02744092

Best to you!
Kara

Thanks for the info, DK! It's always good to get your take on these things because of your expertise!

BsMAb's (bispecific monoclonal antibodies) are hot news! There is a Phase 2 trial in France that uses a recombinant anti-CEA BsMAb and a 177Lu-labeled peptide for the treatment of CEA-expressing small cell lung cancers (SCLC) or CEA-expressing Non Small Cell Lung Carcinoma (NSCLC) using radiation (it's called pretargeted radioimmunotherapy). Since more than 50% of lung cancer shows CEA expression, this is good news for SCLC or NSCLC patients. I'm hoping this will eventually apply to CRC patients with lung mets since we all know how difficult they can be to treat.

We need more agents with novel mechanisms of action (like BsMAb's) to tackle MSS CRC!