Trial at NIH for G12V KRAS mutant

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Maia
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Joined: Fri Aug 24, 2012 8:00 am

Trial at NIH for G12V KRAS mutant

Postby Maia » Mon Jun 19, 2017 1:56 pm

* New trial, the 'Kite' trial
* Immunotherapy, personalized Adoptive T cell therapy
* For G12V Kras mutants, HLA-A 1101 positive.
* AT NIH in Maryland
-------------
* NCT03190941
* New cancer therapy that involves taking white blood cells from a person, growing them in the lab, genetically modifying them, then giving them back to the person. This therapy is called gene transfer using anti-KRAS G12V mTCR cells.
* Combo: Cyclophosphamide + Fludarabine + anti-KRAS G12V mTCR + Aldesleukin
* Maryland NIH

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*1101 Patients
https://clinicaltrials.gov/ct2/show/NCT03190941

SarahS
Posts: 49
Joined: Sat Mar 11, 2017 12:44 pm

Re: Trial at NIH for G12V KRAS mutant

Postby SarahS » Mon Jun 19, 2017 2:41 pm

Thanks for this Maia

I am always keeping an eye open for promising and relevant sounding trials

I am fairly sure my husband has the G12 K Ras mutation, but how would we go about finding out about the HLA-A 1101 positive part?
Wife and caregiver to husband diagnosed with stage 4 colon cancer Nov 2016
Emergency surgery to remove blockage in cecum 12/03/2016
Stage 4 colon cancer. Mets to liver, peritoneum, possibly lungs
K-Ras G12C MSS
01/05/2017 Begin Folfox 6 plus Avastin
CEA pre surgery 114, post surgery 70, 02/2017- 35 03/2017- 23 04/2017- 12

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Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Re: Trial at NIH for G12V KRAS mutant

Postby Maia » Mon Jun 19, 2017 4:13 pm

The HLA-A1101 is a tissue matching test you can order from any hospital, but for those interested in the trial, they probably will run it at the NIH, as part of the screening.

This is the NIH page for it https://clinicalstudies.info.nih.gov/cg ... -0113.html

By the way: this trial is closely related to the TIL trial our Celine underwent, and had success with :)

SarahS
Posts: 49
Joined: Sat Mar 11, 2017 12:44 pm

Re: Trial at NIH for G12V KRAS mutant

Postby SarahS » Mon Jun 19, 2017 5:47 pm

By the way: this trial is closely related to the TIL trial our Celine underwent, and had success with :)

Yes indeed, which is why I am interested :)

Thank you again Maia, you are fantastic
Wife and caregiver to husband diagnosed with stage 4 colon cancer Nov 2016
Emergency surgery to remove blockage in cecum 12/03/2016
Stage 4 colon cancer. Mets to liver, peritoneum, possibly lungs
K-Ras G12C MSS
01/05/2017 Begin Folfox 6 plus Avastin
CEA pre surgery 114, post surgery 70, 02/2017- 35 03/2017- 23 04/2017- 12

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LPL
Posts: 651
Joined: Fri Apr 22, 2016 12:49 am
Location: Europe

Re: Trial at NIH for G12V KRAS mutant

Postby LPL » Thu Jun 22, 2017 10:27 am

Hi Maia,
I see that this Trial is for Kras G12V
Have been reading, trying to learn about the diffent Kras since DH is G13D. He is 'NED for now' but I want to be informed..
Maybe this is not as Interesting as the Trial you posted but it sounds as any Kras mutant is ok here https://clinicaltrials.gov/ct2/show/NCT03101839
DH @ 65 DX 4/11/16 CC recto-sigmoid junction
Adenocarcenoma 35x15x9mm G3(biopsi) G1(surgical)
Mets 3 Liver resectable
T4aN1bM1a IVa 2/9 LN
MSS, KRAS-mut G13D
CEA & CA19-9: 5/18 2.5 78 8/17 1.4 48 2/14/17 1.8 29
4 Folfox 6/15-7/30 (b4 liver surgery) 8 after
CT: 8/8 no change 3/27/17 NED->Jan-19 mets to lung NED again Oct-19 :)
:!: Steroid induced hyperglycemia dx after 3chemo
Surgeries 2016: 3/18 Emergency colostomy
5/23 Primary+gallbl+stoma reversal+port 9/1 Liver mets
RFA 2019: Feb & Oct lung mets

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Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Re: Trial at NIH for G12V KRAS mutant

Postby Maia » Thu Jun 22, 2017 12:27 pm

LPL wrote:Maybe this is not as Interesting as the Trial you posted but it sounds as any Kras mutant is ok here https://clinicaltrials.gov/ct2/show/NCT03101839


That IS a very interesting trial, aimed to the KRAS mutation, LPL :)

In a similar line, with a similar agent, there is
Study of Irinotecan and AZD1775, a Selective Wee 1 Inhibitor, in RAS (KRAS or NRAS) or BRAF Mutated, Second-line Metastatic Colorectal Cancer

https://clinicaltrials.gov/ct2/show/NCT02906059

and other maybe even better, that combines that agent against RAS (KRAS or NRAS) or BRAF with an immunotherapy --
Safety, Tolerability and Pharmacokinetics of AZD1775 Plus MEDI4736 --durvalumab, an anti PD-L1- in Patients With Advanced Solid Tumours
https://clinicaltrials.gov/ct2/show/NCT02617277

This way, one could be targeting the mutation and maybe activating the immune system against the cancer : )

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LPL
Posts: 651
Joined: Fri Apr 22, 2016 12:49 am
Location: Europe

Re: Trial at NIH for G12V KRAS mutant

Postby LPL » Thu Jun 22, 2017 2:33 pm

Thank You Maia,
I don't know how you do it :wink: but you always come up with good info for all of us!
Please do not ever go away <3
DH @ 65 DX 4/11/16 CC recto-sigmoid junction
Adenocarcenoma 35x15x9mm G3(biopsi) G1(surgical)
Mets 3 Liver resectable
T4aN1bM1a IVa 2/9 LN
MSS, KRAS-mut G13D
CEA & CA19-9: 5/18 2.5 78 8/17 1.4 48 2/14/17 1.8 29
4 Folfox 6/15-7/30 (b4 liver surgery) 8 after
CT: 8/8 no change 3/27/17 NED->Jan-19 mets to lung NED again Oct-19 :)
:!: Steroid induced hyperglycemia dx after 3chemo
Surgeries 2016: 3/18 Emergency colostomy
5/23 Primary+gallbl+stoma reversal+port 9/1 Liver mets
RFA 2019: Feb & Oct lung mets


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