CEA increasing trend

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NZJay
Posts: 640
Joined: Mon Dec 16, 2013 3:00 pm
Location: NZ

Re: CEA increasing trend

Postby NZJay » Sat Aug 19, 2017 1:19 am

Another higher than normal CEA guy here - always stayed NED regardless of slight rises
11-13 Dx CC
SPS T4b(touched stomach organ),N1(3/23),M0(Stage 3B)
11-13: resect + partial gastrect
2-14: 1 Tx Cape + Oxy; renal failure, colitis
4-14: 7 Tx Capecitabine
1-15: clear CT
7-15: clear scope
1-16: clear CT
3-17: clear CT
10-17: clear scope (5 year gap now!)
CEA@dx: 8.4 / 6-15: 4.0 / 10-15: 4.2 / 2-16: 4.9 / 7-16: 4.9 / 11-16: 5.0 / 6-17: 4.5
NED since resection

NHMike
Posts: 550
Joined: Fri Jul 21, 2017 3:43 am

Re: CEA increasing trend

Postby NHMike » Sat Aug 19, 2017 8:39 am

JJH wrote:
NHMike wrote:...Do you have a link to what values mean and what normal range is?

The normal range depends on the particular assay or machine used for the test. Your lab report should indicate both the name of the assay/machine and the normal range for it. This might be in small print in a footnote or in small print in the right hand margin.

It is important to know which assay was used because normal ranges for diffrrent assays are different. For example, the Roche assay usually has a higher normal limit than most other assays.

http://coloncancersupport.colonclub.com/viewtopic.php?f=1&t=54299&p=431407#p431407

http://coloncancersupport.colonclub.com/viewtopic.php?f=1&t=51836&p=404364#p404364

http://coloncancersupport.colonclub.com/viewtopic.php?f=1&t=53135&p=419830#p419830


Thanks for the details. I just snapped a picture of the computer screen with my phone so I don't think that the details are on that picture. I do have access on the online portal but I haven't used it yet so I should look around there to see if I can get the details on what kind of equipment they use.
06/23/17: ER rectal bleeding; Colonoscopy+Biopsy
07/13/17: Stage 3B rectal cancer. T3, N1b, M0. 5.2 x 4.5 x 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6 mm, 5 x 5 mm.
Xeloda 3,400 mg/day + radiation 07/31 - 09/08.
CEA 2.7; halfway through treatment: 1.9; after treatment: 1.8.
MSS, KRAS G12D
10/06/17: 2.7 x 2.2 x 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 mm (-75%), 5 x 3 mm (-40%). 5.1 CM from AV.
Surgery: 10/30/17 LAR, Temp Ileostomy

lpas
Posts: 991
Joined: Wed Nov 19, 2014 11:11 pm

Re: CEA increasing trend

Postby lpas » Sat Aug 19, 2017 10:51 pm

Nextgen wrote:Hi All,

Mum CEA drop to 1.1
Praises be the Lord. Amen.


Yay!! So happy for you!
11/14: Dx sigmoid CC @ 45yo
12/14: laparoscopic colectomy, hysterectomy
T3N1bM0, 2/20 nodes, MSS, G2, KRAS(A146T), TP53, SMAD4, ERBB2, CEA 1.0
2/15-7/15: XELOX, celecoxib & many supplements
3/16: Ovarian mass removed. Benign fibroid
9/16: clean colonoscopy
3/17: clean CT
Ongoing: celecoxib, cimetidine & other carefully-targeted supplements
Post-chemo CEA: 3.0, 2.5, 2.3, 2.0, 1.6, 1.3, 1.8, 2.1, 1.8, 2.0, 1.8, 1.9, 1.7, 1.5, 1.6, 1.5, 1.4, 1.4, 1.3, 1.3, 1.6, 1.6
Mom to a 3 & 6yo

User avatar
Shana
Posts: 135
Joined: Sun Jul 30, 2017 9:45 pm
Location: Sonoma, CA

Re: CEA increasing trend

Postby Shana » Sun Aug 20, 2017 8:59 pm

My CEA was around 2900 on 1/3/17. Due to multiple hospitalizations mid January thru June they never retested me after my two rounds of Folfox. I guess they didn't think it mattered much since I was off chemo while trying to recover from various side effects of Folfox.

I asked my oncologist about that when we resumed chemo in July. She was at first alarmed by how high it was (1650) until I asked her what it was the last time and she saw 2900. I am getting CEA tested monthly now, just got the results in the mail and it said >1650, not a specific number. This is after 3 rounds of Irinotecan + Cetuximab. I am getting half dose each week to lessen the side effects so maybe the number will go down after another month of treatment...

I just read about single digit CEA numbers from everyone else that it's making me kind of nervous having such a high number. Could it be because they haven't been able to shrink the tumor enough to remove it? I'll be asking my oncologist these questions, just wondered if anyone else has had a very high CEA come down to single or at least double digits.

Thanks for any feedback :)

Shana
DX - 12/16
MSS - KRAS wild
Stage IV colon cancer with liver mets
5FU - Failed twice - 1/17 and 3/17
Irinotecan + Cetuximab: 8/17 - 2 wks on, 1 wk off to lessen side effects
CT-Scan 9/1/17. Shrinkage of liver mets (4 measurable) and no bowel blockage (surgery on 6/17 for blockage)
Removal and resection not on the table at this time as long as liver mets remain.
BB- aka colostomy is new high maintenance friend... she was a life saver
Living the new normal day by day :)

NHMike
Posts: 550
Joined: Fri Jul 21, 2017 3:43 am

Re: CEA increasing trend

Postby NHMike » Sun Aug 20, 2017 10:14 pm

Shana wrote:My CEA was around 2900 on 1/3/17. Due to multiple hospitalizations mid January thru June they never retested me after my two rounds of Folfox. I guess they didn't think it mattered much since I was off chemo while trying to recover from various side effects of Folfox.

I asked my oncologist about that when we resumed chemo in July. She was at first alarmed by how high it was (1650) until I asked her what it was the last time and she saw 2900. I am getting CEA tested monthly now, just got the results in the mail and it said >1650, not a specific number. This is after 3 rounds of Irinotecan + Cetuximab. I am getting half dose each week to lessen the side effects so maybe the number will go down after another month of treatment...

I just read about single digit CEA numbers from everyone else that it's making me kind of nervous having such a high number. Could it be because they haven't been able to shrink the tumor enough to remove it? I'll be asking my oncologist these questions, just wondered if anyone else has had a very high CEA come down to single or at least double digits.

Thanks for any feedback :)

Shana


I'm just learning about CEA numbers and don't have a feel for the scale outside of normal being between 3 and 5 depending on the equipment in use.

The previous high number that I've seen was in the 200s. I've never seen on in the thousands before and I'd definitely ask my oncologist about it. There are some other factors that can cause a higher number but I didn't see a scale for those causes.
06/23/17: ER rectal bleeding; Colonoscopy+Biopsy
07/13/17: Stage 3B rectal cancer. T3, N1b, M0. 5.2 x 4.5 x 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6 mm, 5 x 5 mm.
Xeloda 3,400 mg/day + radiation 07/31 - 09/08.
CEA 2.7; halfway through treatment: 1.9; after treatment: 1.8.
MSS, KRAS G12D
10/06/17: 2.7 x 2.2 x 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 mm (-75%), 5 x 3 mm (-40%). 5.1 CM from AV.
Surgery: 10/30/17 LAR, Temp Ileostomy

User avatar
Shana
Posts: 135
Joined: Sun Jul 30, 2017 9:45 pm
Location: Sonoma, CA

Re: CEA increasing trend

Postby Shana » Sun Aug 20, 2017 10:50 pm

I just found my first lab work report from 12/13/16 when I was still clueless about everything. My CEA was 6426 :!: I definitely have a downward trend but omg that's a heck of a number. If I knew then what I know now I'd have freaked for sure!

I'll ask questions tomorrow and see if oncologist can shed some light on why my number is so high.
DX - 12/16
MSS - KRAS wild
Stage IV colon cancer with liver mets
5FU - Failed twice - 1/17 and 3/17
Irinotecan + Cetuximab: 8/17 - 2 wks on, 1 wk off to lessen side effects
CT-Scan 9/1/17. Shrinkage of liver mets (4 measurable) and no bowel blockage (surgery on 6/17 for blockage)
Removal and resection not on the table at this time as long as liver mets remain.
BB- aka colostomy is new high maintenance friend... she was a life saver
Living the new normal day by day :)

Nextgen
Posts: 21
Joined: Sun Aug 07, 2016 12:38 pm

Re: CEA increasing trend

Postby Nextgen » Tue Aug 29, 2017 8:41 am

Shana wrote:I just found my first lab work report from 12/13/16 when I was still clueless about everything. My CEA was 6426 :!: I definitely have a downward trend but omg that's a heck of a number. If I knew then what I know now I'd have freaked for sure!

I'll ask questions tomorrow and see if oncologist can shed some light on why my number is so high.



I heard about high cea value in thousands range during my mum chemo times. One told me, Not to focus on it too much, it is just a number, like the number in the bank account.
My mum 55yr on first diagnosis
Dx cc T3N2bM0 on Dec2011 CEA5.0, extended right hemicolectomy Dec2011, 12x Folfox CEA1.9,
Liver mets on Feb2014 CEA6.4, liver resection on May2014, 8x xeloda+cetuximab CEA2.8,
CT scan shows eccentric bowel wall thickening of rectosigmoid region Jul2016 CEA1.8, pending further colonoscopy investigation.
Colonoscopy on Aug2016 NED
CEA 1.4 Nov2016
CEA 1.5 Mar2017
CEA 2.1 Jun2017
CEA 1.1 Aug2017
CEA 2.7 Nov2017
God have mercy, bless & save mum! Amen!

Nextgen
Posts: 21
Joined: Sun Aug 07, 2016 12:38 pm

Re: CEA increasing trend

Postby Nextgen » Tue Aug 29, 2017 8:46 am

lpas wrote:
Nextgen wrote:Hi All,

Mum CEA drop to 1.1
Praises be the Lord. Amen.


Yay!! So happy for you!


Thanks Ipas.
I got so much hope reading at your signature.
I hope we can give hope to others. I know the anxiety ones get when they are sick. Thanks to this forum that sooth my anxiety and give me hope.
My mum 55yr on first diagnosis
Dx cc T3N2bM0 on Dec2011 CEA5.0, extended right hemicolectomy Dec2011, 12x Folfox CEA1.9,
Liver mets on Feb2014 CEA6.4, liver resection on May2014, 8x xeloda+cetuximab CEA2.8,
CT scan shows eccentric bowel wall thickening of rectosigmoid region Jul2016 CEA1.8, pending further colonoscopy investigation.
Colonoscopy on Aug2016 NED
CEA 1.4 Nov2016
CEA 1.5 Mar2017
CEA 2.1 Jun2017
CEA 1.1 Aug2017
CEA 2.7 Nov2017
God have mercy, bless & save mum! Amen!

dschock1102
Posts: 1
Joined: Fri Dec 02, 2016 12:01 pm

Re: CEA increasing trend

Postby dschock1102 » Tue Aug 29, 2017 4:11 pm

Nextgen wrote:
Shana wrote:I just found my first lab work report from 12/13/16 when I was still clueless about everything. My CEA was 6426 :!: I definitely have a downward trend but omg that's a heck of a number. If I knew then what I know now I'd have freaked for sure!

I'll ask questions tomorrow and see if oncologist can shed some light on why my number is so high.



I heard about high cea value in thousands range during my mum chemo times. One told me, Not to focus on it too much, it is just a number, like the number in the bank account.


My wife, diagnosed with stage IV colon cancer (liver mets) at age 32 just weeks after giving birth to our daughter, had an initial CEA of 8,800 at the time of dx (03/2015). She responded well to chemo and had a successful resection (07/2015). She is now 19 months NED since finishing chemo (01/2016) with a steady CEA in the 0.8-1.5 range. We are far from out of the woods, and she battles significant anxiety related to a recurrence, but I hope her story so far can serve as a reminder of the light at the end of the tunnel for so many facing this horrible disease. You are all in my thoughts.

Nextgen
Posts: 21
Joined: Sun Aug 07, 2016 12:38 pm

Re: CEA increasing trend

Postby Nextgen » Tue Aug 29, 2017 7:00 pm

NZJay wrote:Another higher than normal CEA guy here - always stayed NED regardless of slight rises


Very encouraging man! Gbu !
My mum 55yr on first diagnosis
Dx cc T3N2bM0 on Dec2011 CEA5.0, extended right hemicolectomy Dec2011, 12x Folfox CEA1.9,
Liver mets on Feb2014 CEA6.4, liver resection on May2014, 8x xeloda+cetuximab CEA2.8,
CT scan shows eccentric bowel wall thickening of rectosigmoid region Jul2016 CEA1.8, pending further colonoscopy investigation.
Colonoscopy on Aug2016 NED
CEA 1.4 Nov2016
CEA 1.5 Mar2017
CEA 2.1 Jun2017
CEA 1.1 Aug2017
CEA 2.7 Nov2017
God have mercy, bless & save mum! Amen!

Nextgen
Posts: 21
Joined: Sun Aug 07, 2016 12:38 pm

Re: CEA increasing trend

Postby Nextgen » Sun Sep 10, 2017 6:26 pm

dschock1102 wrote:
Nextgen wrote:
Shana wrote:I just found my first lab work report from 12/13/16 when I was still clueless about everything. My CEA was 6426 :!: I definitely have a downward trend but omg that's a heck of a number. If I knew then what I know now I'd have freaked for sure!

I'll ask questions tomorrow and see if oncologist can shed some light on why my number is so high.



I heard about high cea value in thousands range during my mum chemo times. One told me, Not to focus on it too much, it is just a number, like the number in the bank account.


My wife, diagnosed with stage IV colon cancer (liver mets) at age 32 just weeks after giving birth to our daughter, had an initial CEA of 8,800 at the time of dx (03/2015). She responded well to chemo and had a successful resection (07/2015). She is now 19 months NED since finishing chemo (01/2016) with a steady CEA in the 0.8-1.5 range. We are far from out of the woods, and she battles significant anxiety related to a recurrence, but I hope her story so far can serve as a reminder of the light at the end of the tunnel for so many facing this horrible disease. You are all in my thoughts.



Brave cancer fighter ! Keep positiveness, may god bless your wife n u!
My mum 55yr on first diagnosis
Dx cc T3N2bM0 on Dec2011 CEA5.0, extended right hemicolectomy Dec2011, 12x Folfox CEA1.9,
Liver mets on Feb2014 CEA6.4, liver resection on May2014, 8x xeloda+cetuximab CEA2.8,
CT scan shows eccentric bowel wall thickening of rectosigmoid region Jul2016 CEA1.8, pending further colonoscopy investigation.
Colonoscopy on Aug2016 NED
CEA 1.4 Nov2016
CEA 1.5 Mar2017
CEA 2.1 Jun2017
CEA 1.1 Aug2017
CEA 2.7 Nov2017
God have mercy, bless & save mum! Amen!

User avatar
Shana
Posts: 135
Joined: Sun Jul 30, 2017 9:45 pm
Location: Sonoma, CA

Re: CEA increasing trend

Postby Shana » Sun Sep 10, 2017 8:34 pm

dschock1102 wrote:
Nextgen wrote:
Shana wrote:I just found my first lab work report from 12/13/16 when I was still clueless about everything. My CEA was 6426 :!: I definitely have a downward trend but omg that's a heck of a number. If I knew then what I know now I'd have freaked for sure!

I'll ask questions tomorrow and see if oncologist can shed some light on why my number is so high.



I heard about high cea value in thousands range during my mum chemo times. One told me, Not to focus on it too much, it is just a number, like the number in the bank account.


My wife, diagnosed with stage IV colon cancer (liver mets) at age 32 just weeks after giving birth to our daughter, had an initial CEA of 8,800 at the time of dx (03/2015). She responded well to chemo and had a successful resection (07/2015). She is now 19 months NED since finishing chemo (01/2016) with a steady CEA in the 0.8-1.5 range. We are far from out of the woods, and she battles significant anxiety related to a recurrence, but I hope her story so far can serve as a reminder of the light at the end of the tunnel for so many facing this horrible disease. You are all in my thoughts.


Thank you for sharing such positive success especially with a high CEA. I can imagine her anxiety, I'm sure every survivor has those thoughts tucked in the back of their mind. I wish your wife continued NED and all the best to your family. We all appreciate hearing good result stories which gives us all hope!
DX - 12/16
MSS - KRAS wild
Stage IV colon cancer with liver mets
5FU - Failed twice - 1/17 and 3/17
Irinotecan + Cetuximab: 8/17 - 2 wks on, 1 wk off to lessen side effects
CT-Scan 9/1/17. Shrinkage of liver mets (4 measurable) and no bowel blockage (surgery on 6/17 for blockage)
Removal and resection not on the table at this time as long as liver mets remain.
BB- aka colostomy is new high maintenance friend... she was a life saver
Living the new normal day by day :)

Nextgen
Posts: 21
Joined: Sun Aug 07, 2016 12:38 pm

Re: CEA increasing trend

Postby Nextgen » Thu Nov 23, 2017 4:29 pm

Nov 2017 CEA reading is 2.7 - up again, although still within spec of 5.
I noticed C Reactive Protein (CRP) also elevated 6.3 mg/L
It is another sign of inflammation in the body.

Anyone has study about correlation of CRP with CEA or Cancer recurrence? Please share.

Can't help with my anxiety again! God have mercy! Amen!
My mum 55yr on first diagnosis
Dx cc T3N2bM0 on Dec2011 CEA5.0, extended right hemicolectomy Dec2011, 12x Folfox CEA1.9,
Liver mets on Feb2014 CEA6.4, liver resection on May2014, 8x xeloda+cetuximab CEA2.8,
CT scan shows eccentric bowel wall thickening of rectosigmoid region Jul2016 CEA1.8, pending further colonoscopy investigation.
Colonoscopy on Aug2016 NED
CEA 1.4 Nov2016
CEA 1.5 Mar2017
CEA 2.1 Jun2017
CEA 1.1 Aug2017
CEA 2.7 Nov2017
God have mercy, bless & save mum! Amen!


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