Larotrectinib at ASCO 2017

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sjywolf268
Posts: 21
Joined: Fri May 26, 2017 4:50 am

Larotrectinib at ASCO 2017

Postby sjywolf268 » Wed Jun 07, 2017 6:37 pm

Is Larotrectinib so promising even for us Colonated??
colon cancer - April 2016
51 yrs old at diagnoses
stage 4 - 6/14 lymph positive
surgery - April 2006
FOLFOX 12 rounds august 2016
5FU 6rounds Febrary 2017

SarahS
Posts: 49
Joined: Sat Mar 11, 2017 12:44 pm

Re: Larotrectinib at ASCO 2017

Postby SarahS » Wed Jun 07, 2017 6:49 pm

According to this article, yes , colorectal is mentioned butt I don't understand the "TRK fusion" part.

https://ir.loxooncology.com/press-relea ... linical-on
Wife and caregiver to husband diagnosed with stage 4 colon cancer Nov 2016
Emergency surgery to remove blockage in cecum 12/03/2016
Stage 4 colon cancer. Mets to liver, peritoneum, possibly lungs
K-Ras G12C MSS
01/05/2017 Begin Folfox 6 plus Avastin
CEA pre surgery 114, post surgery 70, 02/2017- 35 03/2017- 23 04/2017- 12

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Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Re: Larotrectinib at ASCO 2017

Postby Maia » Wed Jun 07, 2017 8:48 pm

TRK mutation is quite unusual in CRC but if one has that one, yes, this is definitely something to try to gain time, since it seems to be very active against the mutation.
To know the status of such mutation, genetic testing like Foundation One, MSK Impact, Caris, Oncoplex, etc. would be needed.

sjywolf268
Posts: 21
Joined: Fri May 26, 2017 4:50 am

Re: Larotrectinib at ASCO 2017

Postby sjywolf268 » Thu Jun 08, 2017 7:37 am

Maia wrote:To know the status of such mutation, genetic testing like Foundation One, MSK Impact, Caris, Oncoplex, etc. would be needed.


Sorry what is this stuff??
colon cancer - April 2016
51 yrs old at diagnoses
stage 4 - 6/14 lymph positive
surgery - April 2006
FOLFOX 12 rounds august 2016
5FU 6rounds Febrary 2017

User avatar
Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Re: Larotrectinib at ASCO 2017

Postby Maia » Thu Jun 08, 2017 4:55 pm

All those are different types of genomic testing of tumors.
Most patients are tested for the KRAS mutation and, hopefully, more are tested for the BRAF mutation these days. Sometimes, added to that, some people get tested for TP53, APC and a couple of more. These tests I mention here --the one from Foundation One, other called Caris, the one from Memorial Sloan Kettering in NY, Oncoplex from the University of Washington, in Seattle WA-- are wider in their reach, they test for look at hundreds of genes, finding clinically relevant gene changes, that the doctors might be able to target.

Fundation One https://www.foundationmedicine.com/geno ... dation-one
MSKCC Impact https://www.mskcc.org/msk-impact
UW Oncoplex http://web.labmed.washington.edu/tests/ ... W-OncoPlex
Caris https://www.carismolecularintelligence.com/

And this is part of more of those tests, even if it is not mutation: all CRC patients from stage II to higher NEED TO BE TESTED TO DETERMINE MICROSATELLITE STATUS.
That is, if they are MSS --microsatellite stable-- or MSI -High -- microsatellite in-stable---. That determines course of treatment, at the present.

sjywolf268
Posts: 21
Joined: Fri May 26, 2017 4:50 am

Re: Larotrectinib at ASCO 2017

Postby sjywolf268 » Fri Jun 09, 2017 5:21 pm

so i wrote to them and this is the answer

Hello Luca & thanks for your inquiry.
We have trials opened globally for larotrectinib including Spain, Portugal, France, the U.K. & Denmark.
Eligibility requirements include the presence of an NTRK fusion in the tumor.
Are you inquiring for yourself, & if so has your tumor been tested?
Please feel free to call 855-NTRK-123 to learn more about testing or send along your phone number & some available times to reach you
Best,
colon cancer - April 2016
51 yrs old at diagnoses
stage 4 - 6/14 lymph positive
surgery - April 2006
FOLFOX 12 rounds august 2016
5FU 6rounds Febrary 2017

Basil
Posts: 262
Joined: Thu Mar 16, 2017 12:33 pm

Re: Larotrectinib at ASCO 2017

Postby Basil » Fri Jun 09, 2017 8:09 pm

Forgive me for asking this question. It's not as much laziness as not wanting google to give me news I don't understand or plain don't want to hear. I talked with my PA this week and learned my micro satellite status in passing. Didn't understand really what she was saying. Is one better or worse for prognosis and/or treatment? If so, which do I want to be?
40 y/o male, kids 8&11
Dx 3/16/17, rectal cancer s3,t3,n1,m0
PROSPCT trial (FOLFOX in lieu of chemorad)
FOLFOX 4/5/17 - 6/26/17
LAR 7/31/17, temp ileo
pathological complete response
Adjuvant chemo cancelled (IDEA Study)
Ileo reversed 9/25/17
NED
1 year scans - clear
2 year scans - clear

sjywolf268
Posts: 21
Joined: Fri May 26, 2017 4:50 am

Re: Larotrectinib at ASCO 2017

Postby sjywolf268 » Fri Jun 09, 2017 9:42 pm

Basil wrote:Forgive me for asking this question. It's not as much laziness as not wanting google to give me news I don't understand or plain don't want to hear. I talked with my PA this week and learned my micro satellite status in passing. Didn't understand really what she was saying. Is one better or worse for prognosis and/or treatment? If so, which do I want to be?


micro satellite could be MSS or MSI
they both sucks but for future treatment as immonoterapy, they say
MSI is more manageable then MSS
colon cancer - April 2016
51 yrs old at diagnoses
stage 4 - 6/14 lymph positive
surgery - April 2006
FOLFOX 12 rounds august 2016
5FU 6rounds Febrary 2017

Siti
Posts: 103
Joined: Thu Aug 01, 2019 10:58 am

Re: Larotrectinib at ASCO 2017

Postby Siti » Tue Sep 24, 2019 3:04 am

Wife of DH (54) DX on 5/7/19
CEA value: 1.2
T loc: Sigmoid
T type: Adenocarcinoma
T grade: G3
Pos LNs: 30/31
Wild Type for KRAS, NRAS and BRAF
19/7/19 PET-CT Scan: Distant lymph nodes (para-aorta, neck & hip), est. size 0.5-1.5cm.
22/7/19 Surgery: Laparoscopic Colon Resection
26/8/19 Chemo: CAPEOX + Avastin x 9
6/11/19 CT Scan after 3rd cycle, all nodes have shrunk! Yay!!


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