Spice Trial

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Pita
Posts: 637
Joined: Wed Feb 10, 2016 3:48 pm
Location: So Calif

Spice Trial

Postby Pita » Sun Jun 04, 2017 7:44 am

Consent forms signed on Friday and I will begin the 9 week Spice trial NCT02636036 with Nivolumab/Opdivo and Enadenotucirev/Onolytic virus at the City of Hope Tuesday June 6.
Hoping I have smooth sailing as far as symptoms go and also have some reduction on the 6 lesions in my lungs. Will keep you up to date...

Testing required was a CT scan, EKG, 13 tubes of blood, a lung biopsy and a million questions and papers to read/sign.
70yo Fem DX: 1/21/2016 RC Stage IV-Nodules lungs
MSS-Kras Wild-Lynch Synd Neg-Lung Biopsy 1/27/16-Port 2/19/16
MRI 7/7/16 Endometrial polyp found, watching LAR 7/19/16, No Ileostomy, Stage ypT3 N1
CT 11/7/16: Most mets stable,1 shrunk,1 new??
CEA Tests: 1/21/16=20, 12/22/16=5.3, 1/20/17=4.8, 2/15/17=6.2
9/20/16-1/24/17 Folfuri & Avastin
#10/10 Done
PET/CT 2/10/16-1/31/17=Some shrunk & growth to 2, Avastin failing ??? :evil:
2/21/17 Folfuri & Avastin

jhocno197
Posts: 817
Joined: Mon May 11, 2015 9:33 pm

Re: Spice Trial

Postby jhocno197 » Sun Jun 04, 2017 8:08 am

Hoping it goes fantastically well.
DH - dx Dec 2014, stage IV with bladder & peritoneal involvement - non-resectable
Colostomy
FOLFOX failed
FOLFIRI failed
Tumor actually distending pelvic skin
Not a candidate for last-ditch pelvic exenteration
Stivarga finally begun 2/19/16
Tumor growing/fungating
Lonsurf started 11/18/16
Died 3/10/17

KElizabeth
Posts: 400
Joined: Sat Oct 31, 2015 12:41 pm
Facebook Username: KElizabeth
Location: Omaha

Re: Spice Trial

Postby KElizabeth » Sun Jun 04, 2017 10:21 am

I hope it gets you some shrinkage!
Female age 39- ,2 teens.
Colon Cancer - DX March 2013
Age 34 at DX - Stage III B
Resection surgery -May 2013
FOLFOX - June, 2013 to Sept, 2013
5FU plus leukavorin Sept, 2013 to Dec, 2013
METs liver and lungs discovered Sept, 2015
KRAS - MSS
FOLFIRI plus Avastin - Sept, 2015 - July 2017
Durvalumab and Cediranib Sept 2017 Dec 17
FOLFOX with desensitization protocol - current

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mypinkheaven
Posts: 459
Joined: Fri May 20, 2016 4:29 pm
Facebook Username: Sally Cunningham
Contact:

Re: Spice Trial

Postby mypinkheaven » Sun Jun 04, 2017 11:48 am

Wishing you the very best of luck!! 8)
MSS, KRAS Wild NRAS Mutated
9/2012 CRC IIB Lft Colectomy 0 lymph nodes 0 Chemo
10/2013 CT clear
11/15 CEA 2.7 to 4.6
11/15 Spread to uterus. Hysterectomy
2/16 Pelvic radiation 25, brachytherapy 3
4/16 - 6/16 Xeloda
6/16 CT Several lung nodules 5 mm
8/16 CT Nodules still present. Most stable. Some growth
11/16 Transfer to UCSD Moores
12/16 Folfox + Avastin failed
2/17 Folfiri + Erbitux
8/17 5FU+Erbitux No 5FU bolus
7/18 Spread to vagina
6/18 Folfiri + Avastin + Trametinib
6/18 CEA dropping

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LPL
Posts: 651
Joined: Fri Apr 22, 2016 12:49 am
Location: Europe

Re: Spice Trial

Postby LPL » Sun Jun 04, 2017 12:36 pm

Hi Pita,
The very best of Luck wish from me too!
P.S. Have you seen that I asked you a question in this thread viewtopic.php?f=1&t=57742
DH @ 65 DX 4/11/16 CC recto-sigmoid junction
Adenocarcenoma 35x15x9mm G3(biopsi) G1(surgical)
Mets 3 Liver resectable
T4aN1bM1a IVa 2/9 LN
MSS, KRAS-mut G13D
CEA & CA19-9: 5/18 2.5 78 8/17 1.4 48 2/14/17 1.8 29
4 Folfox 6/15-7/30 (b4 liver surgery) 8 after
CT: 8/8 no change 3/27/17 NED->Jan-19 mets to lung NED again Oct-19 :)
:!: Steroid induced hyperglycemia dx after 3chemo
Surgeries 2016: 3/18 Emergency colostomy
5/23 Primary+gallbl+stoma reversal+port 9/1 Liver mets
RFA 2019: Feb & Oct lung mets

AnnClare
Posts: 241
Joined: Wed Sep 09, 2015 3:31 pm

Re: Spice Trial

Postby AnnClare » Sun Jun 04, 2017 2:09 pm

Pita,

I wish you the greatest of success. Please do keep us posted! :)
42 yr. old female
Rectal cancer Stage 3C T3 N1 M0 - Sept 2015
28 rounds radiation w/Xeloda - Nov - Dec 2015
2/17/16 - Surgery to remove rectal tumor, lymph nodes (2/20+), ovaries & fallopian tubes, temp. ileostomy
3/28/16 - 9/26/16 -12 rounds FOLFOX w/full oxi
Ileo reversal 10/27/16; Port removed 12/1/16
Lung mets confirmed 2/6/17
March-May 2017 - brain mets; brain rad. 5/9-5/29/17

Lee
Posts: 6207
Joined: Sun Apr 16, 2006 4:09 pm

Re: Spice Trial

Postby Lee » Sun Jun 04, 2017 3:20 pm

Pita,

All the best with this trial. I hope you have much success with it. Keep us posted.

Lee
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 16 years and counting!

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Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Re: Spice Trial

Postby Maia » Sun Jun 04, 2017 4:33 pm

You know you have all us cheering up on you!!! Come, oncolytic viruses, get the baddies!!!

TXLiz
Posts: 249
Joined: Thu Sep 22, 2016 3:31 pm

Re: Spice Trial

Postby TXLiz » Sun Jun 04, 2017 9:43 pm

Best of luck! Will be watching for your updates!
Vomiting and blockage 9/19/16 46 y F
R hemi colectomy 9/20/16
Stage 3 B CRC, located in cecum
3 out of 16 lymph nodes positive
perineural invasion/lymphovascular invasion
infiltrating, mod differentiated adenocarcinoma with a mucinous component
separate tumor nodules present in pericolonic adipose tissue
MSI-high
Baseline PET scan clear 9/16 CEA 0.5
FOLFOX 10/16- 3/17
April 16th, CT scan clear. CEA 1.1
Lynch "inconclusive"
Colonoscopy 10/5/2017 clear

BUD2016
Posts: 60
Joined: Sat Sep 10, 2016 3:25 pm

Re: Spice Trial

Postby BUD2016 » Mon Jun 05, 2017 10:16 am

I wish you greatest of success! You are so brave and an example to me and my mother. You are one of those people who will find a solution and will do well. Please keep us updated here. Your news are very important. We so wish you all the best!!!
09/2016: Mom dx/rectal cancer
10/2016: Open surgery. T3N0/Grade 2
11/2016: PET/CT scan shows 5 liver mets in both lobes
11/2016: FOLFOX + Avastin started on her 71st birthday
KRAS gen 2 G13D mutant, BRAF Negative, MSS
03/2017: Oxi stopped after 9th tx, 5FU cntd. CT scans w/ contrast every 2 months - small shrinkage/stable
05/2017: PET/CT progression, started FOLFIRI + AVASTIN
07/2017: MRIs/CT stable
09/2017: MRIs/CT - min progression
09/2017: FOLFIRI + CYRAMZA
11/2017: left us

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HopeForJesse
Posts: 249
Joined: Wed Feb 24, 2016 9:39 am
Location: Philadelphia

Re: Spice Trial

Postby HopeForJesse » Wed Oct 25, 2017 5:54 am

Bumping up - PITA - just wondering how you are doing on the SPICE trial and overall? Sending best wishes.
DH DX 01/16 49 YO inop RC stage IV liver mets
MSS TP53 APC,BRCA2
12/15 CEA 241, FOLFOX to 11/16
LAR/ileo 5/16 Clear margins 1/29 nodes
HAI, reversal, liver resections7/16
FUDR 8/16 -NED 3 mos
Rising CEA 3/17 Xeloda, 5/17 -12/17 Erbitux & Iri stable but lung/lymph mets CEA 2.7
5/18 5 days SBRT radiation to sternum 10/22/18 surgery to remove zyphoid process met
6/11/19 5FU added to cetuximab and irinotecan CEA 16
Ephesians 3:20 Our God is able to do immeasurably more than we can ask or imagine!

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Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Re: Spice Trial

Postby Maia » Wed Oct 25, 2017 9:10 am

Yes, Pita! Update to the Colon Talk fellows!!! :)


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