Ascites. Peritoneal mets confirmed.

Please feel free to read, share your thoughts, your stories and connect with others!
User avatar
Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Re: Ascites. Peritoneal mets confirmed.

Postby Maia » Mon Jun 26, 2017 8:46 pm

LMighty wrote:My mom is MSS so the only option left for her is combining Keytruda with Cotellic and Tecentriq--if we can get them, that is. Our onc is working on that. Most likely he can only get Cotellic though.


Keytruda and Tecentriq are almost equivalent --an anti PD-1 and an anti PD-L1, respectively. One use one or the other, not the two at the same time.
So the combination of Keytruda and Cotellic, IF it is going to work, is equivalent to what it is in the abstarct from ASCO --that is, equivalent to Tecentriq and Cotellic.
It is two agents.
Whatever path you choose, I wish that your mom being comfortable, peaceful and even *happy* is the north that guide treatment!

LMighty
Posts: 98
Joined: Sun Aug 28, 2016 6:16 am
Location: Hong Kong

Re: Ascites. Peritoneal mets confirmed.

Postby LMighty » Tue Jun 27, 2017 3:54 am

Maia wrote:
LMighty wrote:My mom is MSS so the only option left for her is combining Keytruda with Cotellic and Tecentriq--if we can get them, that is. Our onc is working on that. Most likely he can only get Cotellic though.


Keytruda and Tecentriq are almost equivalent --an anti PD-1 and an anti PD-L1, respectively. One use one or the other, not the two at the same time.
So the combination of Keytruda and Cotellic, IF it is going to work, is equivalent to what it is in the abstarct from ASCO --that is, equivalent to Tecentriq and Cotellic.
It is two agents.
Whatever path you choose, I wish that your mom being comfortable, peaceful and even *happy* is the north that guide treatment!

Right, Maia. Now I remember you told me so before. Thanks for the reminder and kind wishes!
Supporter to my mom (64 yr); KRAS wild type; MSS

2012: DX Stage I, rectal cancer; resection and colostomy
5/16: DX Stage III, mets found; right groin lymph node and soft tissue
5-6/16: Radiation + Xeloda
7/16: DX Stage IV, pleural effusion; cancer cells found in fluid
7-12/16: Xelox + Avastin X 6
1/17: Clean PET scan, NED
2/17: Pleural effusion; recurrence
4/17: Iri + Erb X 3
5/17: Ascites; Chemo failed
6/17: Keytruda X 1
7/17: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib)
9/17: At peace

User avatar
Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Re: Ascites. Peritoneal mets confirmed.

Postby Maia » Tue Jun 27, 2017 6:44 am

And remember that Cotellic is just a MEK inhibitor but there are others, maybe more accessible --like trametinib (Mekinist)

LMighty
Posts: 98
Joined: Sun Aug 28, 2016 6:16 am
Location: Hong Kong

Re: Ascites. Peritoneal mets confirmed.

Postby LMighty » Fri Jun 30, 2017 1:19 am

UPDATE: We finally secured supply of both Tecentriq and Cotellic (very expensive of course) and the treatment will start in a few days. I may create a dedicated thread soon as I am sure many members of this board would be interested.
Supporter to my mom (64 yr); KRAS wild type; MSS

2012: DX Stage I, rectal cancer; resection and colostomy
5/16: DX Stage III, mets found; right groin lymph node and soft tissue
5-6/16: Radiation + Xeloda
7/16: DX Stage IV, pleural effusion; cancer cells found in fluid
7-12/16: Xelox + Avastin X 6
1/17: Clean PET scan, NED
2/17: Pleural effusion; recurrence
4/17: Iri + Erb X 3
5/17: Ascites; Chemo failed
6/17: Keytruda X 1
7/17: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib)
9/17: At peace

User avatar
Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Re: Ascites. Peritoneal mets confirmed.

Postby Maia » Tue Jul 11, 2017 8:53 am

LMighty, how is your mom doing? I was looking for to see you in a new thread, but I better ask here : )


Return to “Colon Talk - Colon cancer (colorectal cancer) support forum”



Who is online

Users browsing this forum: Yahoo [Bot] and 31 guests