LMighty, so sorry about the need of repeated tapping for the ascites. I imagine your mom's frustration.
Too early to say about Keytruda's effects so let's just keep hoping for the best.
About Tecentriq, as I've said, maybe it is not worth the hassle, since she's getting Keytruda --an anti PD-1--, which is think to work equivalently to Tecentriq --and anti PD-L1.
Her onc is using already Keytruda off label, I have to say. IF he would think a combination of it with a MEK inhibitor is worth the try --trying to reproduce that trial we discussed previously--, other MEK inhibitor than Cotellic might work equally --as Mekinist, for example, if that one is approved in Hong Kong. But in any case it will be *always* off label, since it's not approved for CRC.
About ascites, I wanted to mention this, in case her onc has some knowledge/ connections about it. In Europe, since 2009 there is an approved intraperitoneal immunotherapy against peritoneal ascites: Catumaxomab, Removab. Removab has been used from the start at the Charité Hospital in Berlin. It is a bispecific (anti-EpCAM x anti-CD3) trifunctional antibody. There have been many trials that led to its approval. https://www.karger.com/Article/Abstract/324667
Scroll down until 'Publications' to see a list of scientific literature about it: https://clinicaltrials.gov/ct2/show/NCT ... mab&rank=6
I'm mention this because I see it has been studied in HONG KONG. Maybe some of the authors of this article has some information for your mom's onc, about if it is available, somehow, there:
Vol.03 No.02(2014), Article ID:52919,8 pages
Intraperitoneal Chemotherapy for Gastric Cancer with Peritoneal Carcinomatosis: Is HIPEC the Only Answer?
Ka-On Lam1*, Betty Tsz-Ting Law2, Simon Ying-Kit Law2, Dora Lai-Wan Kwong1
1Department of Clinical Oncology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China
2Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China
Also, PIPAC viewtopic.php?f=1&t=56641
is now available in Singapore: http://medicine.nus.edu.sg/medsur/pipac.html
as clinical trial https://clinicaltrials.gov/ct2/show/NCT03172416