MSS-CRC Immunotherapy Clinical Trial at ASCO-2017: RO6958688 + Tecentriq (ANTI-PDL1)

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DK37
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Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

MSS-CRC Immunotherapy Clinical Trial at ASCO-2017: RO6958688 + Tecentriq (ANTI-PDL1)

Postby DK37 » Thu May 18, 2017 11:32 am

A short blog post on what I think is the biggest MSS-CRC immunotherapy news coming out of ASCO-2017 this year:
The RO6958688 + Tecentriq (ANTI-PDL1) clinical trial.

https://adventuresinlivingterminallyopt ... anti-pdl1/

Cheers,
-DK37
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

SarahS
Posts: 44
Joined: Sat Mar 11, 2017 12:44 pm

Re: MSS-CRC Immunotherapy Clinical Trial at ASCO-2017: RO6958688 + Tecentriq (ANTI-PDL1)

Postby SarahS » Thu May 18, 2017 1:51 pm

Tom, thank you so very much for everything that you do

I'm actually crying as I type this becasue for the first time in a very long 6 months, I feel like there is some real hope for the future

We will be meeting with Dr Segal at MSK next week and I want to ask him about this trial combination in particular

Thank you and every best wish to you for your future

Sarah
Wife and caregiver to husband diagnosed with stage 4 colon cancer Nov 2016
Emergency surgery to remove blockage in cecum 12/03/2016
Stage 4 colon cancer. Mets to liver, peritoneum, possibly lungs
K-Ras mutant MSS
01/05/2017 Begin Folfox 6 plus Avastin
CEA pre surgery 114, post surgery 70, 02/2017- 35 03/2017- 23 04/2017- 12

Lee
Posts: 5185
Joined: Sun Apr 16, 2006 4:09 pm

Re: MSS-CRC Immunotherapy Clinical Trial at ASCO-2017: RO6958688 + Tecentriq (ANTI-PDL1)

Postby Lee » Thu May 18, 2017 3:51 pm

Ditto.

Interesting and promising. Thank you again, for all that you do here.

Lee
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 10 years and counting!

Tim UK
Posts: 60
Joined: Fri Jun 12, 2015 1:05 am

Re: MSS-CRC Immunotherapy Clinical Trial at ASCO-2017: RO6958688 + Tecentriq (ANTI-PDL1)

Postby Tim UK » Sat May 20, 2017 5:57 pm

This is the trial I'm on, see earlier posts. I started in October '16. The trial is recruiting at multiple sites in the US and here in Europe.

I'm happy to answer any queries either here or via PM, recognizing of course that I'm just one case, and others will likely have different responses.

Tim
https://www.youtube.com/watch?v=qoQbY4A5RNA
05/15 L hemi-colectomy - robotic, laparoscopic
05/15 Dx st 3 T4N2M0 @43
kids: 11,7
BRAFm mucinous - KRASw
06/15 2 liver mets
06/15 CEA 9, CA19-9 400+
06/15 - 09/15 6 x FOLFOXIRI+Avastin
09/15 markers 4/50
10/15 drain-site met
11/15 CRS+HIPEC
1-8/16 BRAF therapy (dabrafenib, panitumumab, trametinib)
CEA;CA19-9: 1/16 16;650 | 2/16 3;690 | 3/16 1;36 | 4/16 2;46 | 5/16 1;29 | 6/16 1;42 | 7/16 2;44 | 8/16 3;72 and 4;135
8/16 progression (PET)
10/16 Trial: NCT02650713

SarahS
Posts: 44
Joined: Sat Mar 11, 2017 12:44 pm

Re: MSS-CRC Immunotherapy Clinical Trial at ASCO-2017: RO6958688 + Tecentriq (ANTI-PDL1)

Postby SarahS » Sat May 20, 2017 7:57 pm

Tim that is very encouraging, I'd been reading about your progress not realizing that the trial you are on was the one Tom is referencing here.
It is especially encouraging to read that you had peritoneal response.
Will you be continuing on with this trial or looking now at something else?
Wife and caregiver to husband diagnosed with stage 4 colon cancer Nov 2016
Emergency surgery to remove blockage in cecum 12/03/2016
Stage 4 colon cancer. Mets to liver, peritoneum, possibly lungs
K-Ras mutant MSS
01/05/2017 Begin Folfox 6 plus Avastin
CEA pre surgery 114, post surgery 70, 02/2017- 35 03/2017- 23 04/2017- 12

sven
Posts: 1
Joined: Wed Oct 11, 2017 10:00 am

Re: MSS-CRC Immunotherapy Clinical Trial at ASCO-2017: RO6958688 + Tecentriq (ANTI-PDL1)

Postby sven » Wed Oct 11, 2017 10:04 am

Hi Tim, could you please tell whether RO6958688  still works for you?


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