CYRAMZA/Ramucirumab with FOLFIRI vs. Avastin + 5FU?

[BUD2016]

Hi All,

Cyramza has been approved in 2015 for mCRC patients failing the first line of treatment (FOLFOX + Avastin). In combination with FOLFIRI. In people KRAS mutant.

We are not taking this route yet, just preparing for Plan B in case something comes up in the scans tomorrow. One must always be prepared and our onc mentioned this possibility in case things do not go as planned.

What I understand is that it is not a breakthrough drug, but some slight enhancement of Avastin. Like a new updated version of Avastin from a different supplier?

I have seen many people still staying on Avastin and side effects are worse on Cyramza than Avastin.

Any views?

Thank you very much for you feedback and sharing your experience.

[GrouseMan]

Ramucirumab is more like a complementary agent to Avastin/Bevacizumab. They both work on the Vascular endothelial growth factor signaling pathway. One works on VEGF-A, the other on VEGFr2 both of which are involved in Angiogenesis.

The following Wiki links may help.

Ramucirumab: https://en.wikipedia.org/wiki/Ramucirumab

Bevacizumab: https://en.wikipedia.org/wiki/Bevacizumab

VEGF-A: https://en.wikipedia.org/wiki/Vascular_ ... h_factor_A

VEGFr2: https://en.wikipedia.org/wiki/Kinase_in ... n_receptor

Overall VEGF family of receptors: https://en.wikipedia.org/wiki/VEGF_receptor

Angiogenesis: https://en.wikipedia.org/wiki/Angiogenesis

A bit technical I know but best to be armed with complete information in my opinion.

Regards,

GrouseMan