Hi Meg – My Wife’s experience went this way:
Rounds 1-3 of FolFox+Avastin with Oxaliplatin – weak, cold sensitivity, out of work for 3 days.
Rounds 4-6 of FolFox+Avastin with Oxaliplatin - Very weak, cold sensitivity worsen, nausea, tingling in digits, constipated, out of work for 5 days.
Rounds 6-8 of FolFox+Avastin with Oxaliplatin - Very very weak, severe cold sensitivity, not eating or drinking for 5 days after chemo, nausea, constipated, Neuropathy setting in on foot/hands, loss of 30 lbs weight, out of work for 2 weeks.
Rounds 8-11 – Oxi Removed just Folfox+Avastin. All bad symptoms removed, minor weakness, legacy Neuropathy lessend, appetite back-gained 5 lbs back on weight, out of work for 2 days only.
The key according to both her Oncs, is to stave off irreparable damage caused by Oxi. In my Wife’s case, the Sloan Dr agreed fully with Roswell Onc and said it was a wise choice to remove Oxi and not push in case surgery or other types of treatment may be necessary in the future, since she may need her strength for other treatments. Each person reacts slight different to the Chemo Stuff. Since Oxi- has been removed, she is a happy camper as far as Chemo side-effects. Wish you the best.
Caregiver for Wife 52 yrs old
DX:11/16-CC sigmoid colon
Lung Mets: Bilateral ranging 4mm-1.5cm
MSS, KRAS-mut G12D; TP53
Completed 12 rounds Folfox/Avastin + Oxi 11/16 to 5/17, 8/17 Start Xeloda + Avastin
CT Scans: 5/17 colon & lung met shrinkage,11/17 and 1/18 slight progression lungs/colon; 5/18 stable lungs/colon
NCI YOUNGER TIL Trial NCT03412877 - 1/18 VATs lung surgery 2 mets wedge resect
CEA: 16 - 11/16; 0.6 - 5/17; 3.0 - 11/17; 4.4 - 1/18; 5.7 - 2/18; 4.9 - 3/18, 4.0 - 5/18