For the bunch of great funny and strong Aussies here
*Only in Australia, several locations
#NCT02726334
*BNC101 (I.V.; anti-LGR5 monoclonal antibody, targets stem cancer cells). An Aussie development.
* BNC101 monotherapy (for those who had two or more lines of chemo not longer working)
* BNC101 + Folfiri (for those who had at least one line of chemo not longer working)
https://clinicaltrials.gov/ct2/show/NCT02726334
"A humanized monoclonal antibody targeting leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), with potential antineoplastic activity. Upon administration, the anti-LGR5 humanized monoclonal antibody BNC101 targets and binds to LGR5, thereby inhibiting LGR5-mediated signal transduction pathways. This prevents proliferation of LGR5-expressing tumor cells. LGR5, a member of the Wnt signaling pathway, is a cancer stem cell (CSC) receptor overexpressed on certain cancer cells; it plays a key role in CSC proliferation and survival."