Australia Trial with CRC stem cancer cells inhibitor

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Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Australia Trial with CRC stem cancer cells inhibitor

Postby Maia » Fri Mar 24, 2017 2:48 pm

For the bunch of great funny and strong Aussies here :)

*Only in Australia, several locations

#NCT02726334

*BNC101 (I.V.; anti-LGR5 monoclonal antibody, targets stem cancer cells). An Aussie development.

* BNC101 monotherapy (for those who had two or more lines of chemo not longer working)

* BNC101 + Folfiri (for those who had at least one line of chemo not longer working)

https://clinicaltrials.gov/ct2/show/NCT02726334

"A humanized monoclonal antibody targeting leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), with potential antineoplastic activity. Upon administration, the anti-LGR5 humanized monoclonal antibody BNC101 targets and binds to LGR5, thereby inhibiting LGR5-mediated signal transduction pathways. This prevents proliferation of LGR5-expressing tumor cells. LGR5, a member of the Wnt signaling pathway, is a cancer stem cell (CSC) receptor overexpressed on certain cancer cells; it plays a key role in CSC proliferation and survival."

Lee
Posts: 6207
Joined: Sun Apr 16, 2006 4:09 pm

Re: Australia Trial with CRC stem cancer cells inhibitor

Postby Lee » Sun Mar 26, 2017 6:17 pm

BUMP! For those people in Australia who may have missed this the 1st time.

Hi Maia,

Lee
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 16 years and counting!

ozziej
Posts: 239
Joined: Thu May 21, 2015 8:35 pm

Re: Australia Trial with CRC stem cancer cells inhibitor

Postby ozziej » Sun Mar 26, 2017 9:32 pm

Thanks for thinking about we southerners Maia :)
F 56 dx 11/14 Stage 1 RC (post EMR)
No neo-adjuvant or adjuvant chemo/RD
3/15 ULAR (open) temp loop ileo
5/15 ileo reversal
NED and hoping to stay that way!! : )


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