Maia wrote:Plastikos you might like this thread form Big Rob here viewtopic.php?f=1&t=55586
He started it with that mention of that trial but ended up with pembro /Keytruda. Wonderfullymade, I do know you already have read that thread.
plastikos wrote:Maia wrote:Plastikos you might like this thread form Big Rob here viewtopic.php?f=1&t=55586
He started it with that mention of that trial but ended up with pembro /Keytruda. Wonderfullymade, I do know you already have read that thread.
Thanks Maia. Sorry between work and treatments don't get to check the forum everyday.
henry123 wrote:plastikos wrote:Maia wrote:Plastikos you might like this thread form Big Rob here viewtopic.php?f=1&t=55586
He started it with that mention of that trial but ended up with pembro /Keytruda. Wonderfullymade, I do know you already have read that thread.
Thanks Maia. Sorry between work and treatments don't get to check the forum everyday.
How are things , Plastikos.
Stewsbetty wrote:
plastikos wrote:Stewsbetty wrote:
Hi. Things are good overall I think.
Recent developments. Had a PET scan last week which showed a small area of FDG uptake with no corresponding lesion on CT. They ordered an MRI with liver specific contrast which is supposedly the most sensitive/specific imaging for liver mets and it showed nothing. Onc still considers me to be NED. Thinks that the FDG uptake may be either inflammation/scarring from the SIRT OR pseudoprogression (something about lymphocytes aggregating in certain areas). Plan is to continue Keytruda and monitor closely.
Has anyone else experienced having sudden spots on PET scan while on immunotherapy then having them resolve eventually? Also if anyone could point me to an immuno trial with a site in Asia or advise me on how to source Keytruda at a lower cost it would be much appreciated. At present I am paying for the drug out of pocket and I am worried about long term sustainability. I was hoping that after 1 year my onc would consider discontinuing it or at least dosing at longer intervals. With recent questionable findings though looks like that discussion will have ton wait.
plastikos wrote:plastikos wrote:Stewsbetty wrote:
Hi. Things are good overall I think.
Recent developments. Had a PET scan last week which showed a small area of FDG uptake with no corresponding lesion on CT. They ordered an MRI with liver specific contrast which is supposedly the most sensitive/specific imaging for liver mets and it showed nothing. Onc still considers me to be NED. Thinks that the FDG uptake may be either inflammation/scarring from the SIRT OR pseudoprogression (something about lymphocytes aggregating in certain areas). Plan is to continue Keytruda and monitor closely.
Has anyone else experienced having sudden spots on PET scan while on immunotherapy then having them resolve eventually? Also if anyone could point me to an immuno trial with a site in Asia or advise me on how to source Keytruda at a lower cost it would be much appreciated. At present I am paying for the drug out of pocket and I am worried about long term sustainability. I was hoping that after 1 year my onc would consider discontinuing it or at least dosing at longer intervals. With recent questionable findings though looks like that discussion will have ton wait.
I am having my pembro covered through Mercks compassionate care program. I was denied at first but after doing 3 doses on my own and my tumours showing improvement we reapplied and they are now covering my drugs. I hope you find a way to get some aid as the costs accumulate quickly!
henry123 wrote:Hi guys,
Those of you who are on pembro or Opdivo, have you considered adding aspirin to your daily regime. Please discuss with your med oncologist.
It seems at least opdivo gives a better bite for the buck in combination with aspirin.
http://www.bioworld.com/content/nonster ... e-response
But in combination with PD-1 blockers, treatment with NSAIDs strongly reduced tumor growth.
plasricos wrote:
I have been taking Vit D3 supplements since diagnosis in 2014. Even my onc was on board with it. But I kept on getting recurrences. Now I read that Vit D3 actually affects the immune response negatively by reducing inflammation.
LPL wrote:plasricos wrote:
I have been taking Vit D3 supplements since diagnosis in 2014. Even my onc was on board with it. But I kept on getting recurrences. Now I read that Vit D3 actually affects the immune response negatively by reducing inflammation.
Your words make me worried. My DH is also taking Vit D3. He doesn’t have any treatments now. Can you please tell me where you read that Vit D3 affects the immune respons negatively.
Thank you in advance /LPL
henry123 wrote:Even my oncologist has asked me to be off any supplements. I only take aspirin on his advice and occasional curcumin tablets.
These immunotherapy drugs are so new that doctors don't have data on drug interactions.
If I understood the paper on Vit D and pdl1, it may be harmful at high doses. Please correct if I am wrong.
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