Maia wrote:I'm glad to hear you're doing well, and that you took such decition. Anti PD-1 will be probably approved this month, for MSI-high. Many responding to it just as monotherapy and, when doesn't work that way, it is clear that it packs a punch when combined with Avastin.
Atezolizumab/Bevacizumab Combo Attains 90% DCR in MSI-High mCRC
Published Online: Tuesday, Feb 07, 2017
- See more at: http://www.onclive.com/web-exclusives/a ... SQYED.dpuf
ADDING Avastin (bevacizumab) to Keytruda seems to pack an even greater punch for MSI-H / Lynch. Combo of anti PD-1/PD-L1 (Keytruda, Opdivo, atezo, durva, etc.) plus Avastin. See the trial Stephen is on viewtopic.php?f=1&t=51990
http://fightcolorectalcancer.org/blog/t ... ot-part-1/
http://fightcolorectalcancer.org/blog/t ... ot-part-2/
Just in case you still are looking for something else, I posted recently a couple of trials for a fellow in Singapore, here viewtopic.php?f=1&t=56745#p452895 He's MSS and those trials might be promising even for him (keep in mind that, in general, more anti-PD1 are equal, just other pharma)
A recent post that might be of your interest too (watch the video) viewtopic.php?f=1&t=57401
plastikos wrote:Update:
Had 3 infusions of Pembrolizumab (every 3 weeks). PET-CT still shows basically the same lesions with a very minimal decreases in their respective sizes. But all of them are now non-hypermetabolic on PET. I was hoping, maybe even expecting, a more dramatic change but all in all it is still good I think. Not sure how long PD-1 inhibitors take to take effect.
Lee wrote:plastikos wrote:Update:
Had 3 infusions of Pembrolizumab (every 3 weeks). PET-CT still shows basically the same lesions with a very minimal decreases in their respective sizes. But all of them are now non-hypermetabolic on PET. I was hoping, maybe even expecting, a more dramatic change but all in all it is still good I think. Not sure how long PD-1 inhibitors take to take effect.
Decrease in size even minimal is a good think. I understand your frustration in wanting a more dramatic change.
Are you considering Avastin?
All the best,
Lee
plastikos wrote:Thanks. Onc hasn't mentioned Avastin yet. Did you mean combination with the Pembro? Is the data on it out?
plastikos wrote:Onc hasn't mentioned Avastin yet. Did you mean combination with the Pembro? Is the data on it out?
plastikos wrote:Update:
Had 3 infusions of Pembrolizumab (every 3 weeks). PET-CT still shows basically the same lesions with a very minimal decreases in their respective sizes. But all of them are now non-hypermetabolic on PET. I was hoping, maybe even expecting, a more dramatic change but all in all it is still good I think. Not sure how long PD-1 inhibitors take to take effect.
Lee wrote:plastikos wrote:Thanks. Onc hasn't mentioned Avastin yet. Did you mean combination with the Pembro? Is the data on it out?
I'm not aware of any data on this at this time. Was just wondering if you were thinking of it as you were "hoping for a more dramatic change" under current treatment plan.
Keytruda has been successful for BeansMama, I'm assuming you are getting the same thing. Maybe give it a bit more time.
Any comments from your Onc on your most recent PET CT?
Lee
Maia wrote:plastikos wrote:Update:
Had 3 infusions of Pembrolizumab (every 3 weeks). PET-CT still shows basically the same lesions with a very minimal decreases in their respective sizes. But all of them are now non-hypermetabolic on PET. I was hoping, maybe even expecting, a more dramatic change but all in all it is still good I think. Not sure how long PD-1 inhibitors take to take effect.
Minimal decreases, non-hypermetabolic on PET, not experience adverse effects is wonderful. You just keep going, and living. Sometimes immunotherapy takes many time to work --there are reports of people who left trials, because side effects or apparent progression, and have results from the immunotherapy months after discontinuation.
If you search for Stephen's case --trial with atezolizumb + avastin, he's MSI-high; I provided you the link in a previous post-- you will see that he's only recently NED, after more than one year on the trial --maybe two, I don't remember now.
The key is how you're feeling.
Maia wrote:
The data is out for atezolizumab + bevacizumab --the one quoted above in this post. Atezo is an anti PD-L1, pembrolizumab is an anti PD-1, but so far, in general, they are showing practically similar results.
You always can go for almost *any* trial for MSS CRC or solid tumours that combines one anti PD-1/PD-L1 plus something else: IDO1 inhibitor, GITR inhibitor, TIG --all immuno--, even chemo or targeted agent. That X, in addition to the PD-1/L-1 checkpoint inhibitor, might be enough to make a MSI-high tumour more responsive to treatment.
Return to “Colon Talk - Colon cancer (colorectal cancer) support forum”
Users browsing this forum: Google [Bot] and 145 guests