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Re: Napabucasin and Folfiri plus Avastin- anyone on this trial?
Posted: Wed Mar 22, 2017 10:42 pm
by KElizabeth
aja1121 wrote:My husband and I met with an oncologist at Mayo Clinic on March 20 regarding BBI608 and FOLFIRI +/- Avastin. Oncologist told us there are currently 91 open slots in the trial nationwide. He also said that in initial Phase I trials a few years back, the side effects of BBI608 were so harsh he had little hope for the drug. He now feels very positive about the results they are seeing, and said they seem to have found the "sweet spot" for dosage in terms of limiting side effects.
Most recent scan last week showed control/minor shrinkage on Xeloda/Avastin, so we are sticking with that for now and keeping trial in our back pocket. Just thought I'd share for those interested.
(Trial info again,
https://clinicaltrials.gov/ct2/show/NCT02753127)
Thanks for the info. I had heard the side effects were similar to Folfiri alone and I hope it's true.
I got the trial nurse at one of the centers to take my records finally, so I guess I'm on the road to finding out if I will be in this trial. Fingers crossed.
Re: Napabucasin and Folfiri plus Avastin- anyone on this trial?
Posted: Fri Mar 24, 2017 9:39 am
by Maia
So glad to hear, KElizabeth!
Everything crossed for you!!
Re: Napabucasin and Folfiri plus Avastin- anyone on this trial?
Posted: Sat Mar 25, 2017 2:46 am
by Steph20021
Hope you hear back soon on the trial Elizabeth. Question for you. Have you been on folfiri since sept 2015 continuously? And it's been keeping you stable all this time?
Re: Napabucasin and Folfiri plus Avastin- anyone on this trial?
Posted: Sat Mar 25, 2017 1:01 pm
by KElizabeth
Steph20021 wrote:Hope you hear back soon on the trial Elizabeth. Question for you. Have you been on folfiri since sept 2015 continuously? And it's been keeping you stable all this time?
Yes. I've had 39 treatments over tge past 18 months with only a week break here and there for holidays or vacation. I am stable-ish. My CEA was creeping prior to my microwave ablation but the cause wasn't evident on scans. My CEA is trending down currently. The side effects have changed too. My hair has started to come back and the diarrhea decreased. I'm just more fatigued.
Re: Napabucasin and Folfiri plus Avastin- anyone on this trial?
Posted: Tue Aug 29, 2017 4:32 pm
by aja1121
Quick update... scans in July showed minor progression on Xeloda/Avastin. Received word today that my husband has been accepted into NCT02024607 (BBI608, also known as Napabucasin + FOLFIRI arm) at Mayo Clinic. He will take his first dose of the drug this Friday 9/1, and will get his first infusion of FOLFIRI on 9/6. They will scan again after 4 infusions. Fingers crossed that he can tolerate the drug, and that we see some tumor regression.
Re: Napabucasin and Folfiri plus Avastin- anyone on this trial?
Posted: Tue Mar 13, 2018 1:38 pm
by aja1121
My husband had two stable scans on the BBI-608 trial with FOLFIRI. At that point, due to some unrelated kidney problems (ureter obstruction caused by radiation) he was unable to receive FOLFIRI for seven weeks and unfortunately the next scan showed progression. However, growth WAS controlled when he was able to have chemo, so if you are considering this trial, please don’t rule it out. Others have had stable disease for up to a year.
Kidney problems have been addressed with nephrostomy tubes. We’re looking at another trial option at Mayo and hope to start in a couple of weeks.