Napabucasin and Folfiri plus Avastin- anyone on this trial?

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KElizabeth
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Joined: Sat Oct 31, 2015 12:41 pm
Facebook Username: KElizabeth
Location: Omaha

Re: Napabucasin and Folfiri plus Avastin- anyone on this trial?

Postby KElizabeth » Wed Mar 22, 2017 10:42 pm

aja1121 wrote:My husband and I met with an oncologist at Mayo Clinic on March 20 regarding BBI608 and FOLFIRI +/- Avastin. Oncologist told us there are currently 91 open slots in the trial nationwide. He also said that in initial Phase I trials a few years back, the side effects of BBI608 were so harsh he had little hope for the drug. He now feels very positive about the results they are seeing, and said they seem to have found the "sweet spot" for dosage in terms of limiting side effects.

Most recent scan last week showed control/minor shrinkage on Xeloda/Avastin, so we are sticking with that for now and keeping trial in our back pocket. Just thought I'd share for those interested.

(Trial info again, https://clinicaltrials.gov/ct2/show/NCT02753127)


Thanks for the info. I had heard the side effects were similar to Folfiri alone and I hope it's true.
I got the trial nurse at one of the centers to take my records finally, so I guess I'm on the road to finding out if I will be in this trial. Fingers crossed.
Female age 39- ,2 teens.
Colon Cancer - DX March 2013
Age 34 at DX - Stage III B
Resection surgery -May 2013
FOLFOX - June, 2013 to Sept, 2013
5FU plus leukavorin Sept, 2013 to Dec, 2013
METs liver and lungs discovered Sept, 2015
KRAS - MSS
FOLFIRI plus Avastin - Sept, 2015 - July 2017
Durvalumab and Cediranib Sept 2017 Dec 17
FOLFOX with desensitization protocol - current

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Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Re: Napabucasin and Folfiri plus Avastin- anyone on this trial?

Postby Maia » Fri Mar 24, 2017 9:39 am

So glad to hear, KElizabeth!
Everything crossed for you!!

Steph20021
Posts: 513
Joined: Sat Dec 27, 2014 4:58 pm
Location: Ontario, Canada

Re: Napabucasin and Folfiri plus Avastin- anyone on this trial?

Postby Steph20021 » Sat Mar 25, 2017 2:46 am

Hope you hear back soon on the trial Elizabeth. Question for you. Have you been on folfiri since sept 2015 continuously? And it's been keeping you stable all this time?
DX 1/31/14 @ 33- SPS-T4a(invades visceral peri), N2a(6/106 LN), M1a(ovary) (Stage 4a) MSS
2/1/14-subtotal col, lost R ovary, temp ileo
3/14-9/14- folfox; sepsis
11/14-CT/PET: L ovary met, pelvic met, (?)ghost liver met(?)
12/14-folfiri -13 rds kept me stable from 3/15-6/15
8/15-HIPEC, hysterectomy et al, 2nd temp ileo, NED?
09/15- cea 0.9
05/16- recurrence in abdo wall and lymph nodes
Jan/17- pulmonary embolism
Feb/17- 1 wk radiation to abdo wall
Currently stable suce Aug/16- on folfiri

KElizabeth
Posts: 400
Joined: Sat Oct 31, 2015 12:41 pm
Facebook Username: KElizabeth
Location: Omaha

Re: Napabucasin and Folfiri plus Avastin- anyone on this trial?

Postby KElizabeth » Sat Mar 25, 2017 1:01 pm

Steph20021 wrote:Hope you hear back soon on the trial Elizabeth. Question for you. Have you been on folfiri since sept 2015 continuously? And it's been keeping you stable all this time?

Yes. I've had 39 treatments over tge past 18 months with only a week break here and there for holidays or vacation. I am stable-ish. My CEA was creeping prior to my microwave ablation but the cause wasn't evident on scans. My CEA is trending down currently. The side effects have changed too. My hair has started to come back and the diarrhea decreased. I'm just more fatigued.
Female age 39- ,2 teens.
Colon Cancer - DX March 2013
Age 34 at DX - Stage III B
Resection surgery -May 2013
FOLFOX - June, 2013 to Sept, 2013
5FU plus leukavorin Sept, 2013 to Dec, 2013
METs liver and lungs discovered Sept, 2015
KRAS - MSS
FOLFIRI plus Avastin - Sept, 2015 - July 2017
Durvalumab and Cediranib Sept 2017 Dec 17
FOLFOX with desensitization protocol - current

aja1121
Posts: 212
Joined: Sat Jun 28, 2014 5:12 pm

Re: Napabucasin and Folfiri plus Avastin- anyone on this trial?

Postby aja1121 » Tue Aug 29, 2017 4:32 pm

Quick update... scans in July showed minor progression on Xeloda/Avastin. Received word today that my husband has been accepted into NCT02024607 (BBI608, also known as Napabucasin + FOLFIRI arm) at Mayo Clinic. He will take his first dose of the drug this Friday 9/1, and will get his first infusion of FOLFIRI on 9/6. They will scan again after 4 infusions. Fingers crossed that he can tolerate the drug, and that we see some tumor regression.
DH dx Stage 3B rectal ca 5/23/14 (age 41)
6/14 chemorad | 10/14 LAR, all nodes clean
12/14-04/15 FOLFOX x 10
05/15 VATS/lung met, 06/15 ileo reversal
09/15 local recurrence, 10/15 colostomy
11/15 FOLFIRI x 4, major growth, 02/16 tumor debulked
11/16 Xeloda/Avastin until progression 08/17
09/17 start NCT02024607 (BBI608 + FOLFIRI arm) until progression 02/18
03/26/18 start NCT02817633 (anti-PD-1 + anti-TIM-3) until progression 06/19/18
06/19/18 start NCT03175224 (c-Met inhibitor)

aja1121
Posts: 212
Joined: Sat Jun 28, 2014 5:12 pm

Re: Napabucasin and Folfiri plus Avastin- anyone on this trial?

Postby aja1121 » Tue Mar 13, 2018 1:38 pm

My husband had two stable scans on the BBI-608 trial with FOLFIRI. At that point, due to some unrelated kidney problems (ureter obstruction caused by radiation) he was unable to receive FOLFIRI for seven weeks and unfortunately the next scan showed progression. However, growth WAS controlled when he was able to have chemo, so if you are considering this trial, please don’t rule it out. Others have had stable disease for up to a year.

Kidney problems have been addressed with nephrostomy tubes. We’re looking at another trial option at Mayo and hope to start in a couple of weeks.
DH dx Stage 3B rectal ca 5/23/14 (age 41)
6/14 chemorad | 10/14 LAR, all nodes clean
12/14-04/15 FOLFOX x 10
05/15 VATS/lung met, 06/15 ileo reversal
09/15 local recurrence, 10/15 colostomy
11/15 FOLFIRI x 4, major growth, 02/16 tumor debulked
11/16 Xeloda/Avastin until progression 08/17
09/17 start NCT02024607 (BBI608 + FOLFIRI arm) until progression 02/18
03/26/18 start NCT02817633 (anti-PD-1 + anti-TIM-3) until progression 06/19/18
06/19/18 start NCT03175224 (c-Met inhibitor)


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