Rovalpituzumab
Rovalpituzumab
Has anyone been on a trial for this? Been off this site for some time and then couldn't find you! They only pay for the drug and my ins (aka me due to deductible) has to pay for everything else involved as long as it is under "Standard of Care". That would out me OOP up to $7G for them to get to test THEIR drug. If I knew anything about the drug, that would help.
6/13 Age 45 mom of 11 and 13 yr old DX Stage IV liver mets
7/13 colon surgery
9/13 Folfox
11/13 Xeliri
3/14 more liver mets
4/14 Lung Met
4/14 Liver resect delayed;lung resect done
5/14 Surg not an option
9/14 Stivarga
3/15 Back to IV Chemo
6/15 Avastin
9/15 In Clinical Trial
7/13 colon surgery
9/13 Folfox
11/13 Xeliri
3/14 more liver mets
4/14 Lung Met
4/14 Liver resect delayed;lung resect done
5/14 Surg not an option
9/14 Stivarga
3/15 Back to IV Chemo
6/15 Avastin
9/15 In Clinical Trial
Re: Rovalpituzumab
Ohhhh, look who is here!! 
So happy to see you!!!
I don't know anyone on rovalpituzumab for CRC but wanted to point out that you might want to catch up reading here
viewtopic.php?f=1&t=56842
and here
viewtopic.php?f=1&t=49736&start=390#p447644 , specially.
BTW... the BBI608 that you took under a trial, a couple of years ago, is making good progress in combinations, closer to get approved
Keep the good going!
ETA: how old are your kids now???
So happy to see you!!!
I don't know anyone on rovalpituzumab for CRC but wanted to point out that you might want to catch up reading here
viewtopic.php?f=1&t=56842
and here
viewtopic.php?f=1&t=49736&start=390#p447644 , specially.
BTW... the BBI608 that you took under a trial, a couple of years ago, is making good progress in combinations, closer to get approved
Keep the good going!
ETA: how old are your kids now???
Re: Rovalpituzumab
Thanks Maia! My daughter just turned 17 on Wednesday and My son will be 15 in May.
6/13 Age 45 mom of 11 and 13 yr old DX Stage IV liver mets
7/13 colon surgery
9/13 Folfox
11/13 Xeliri
3/14 more liver mets
4/14 Lung Met
4/14 Liver resect delayed;lung resect done
5/14 Surg not an option
9/14 Stivarga
3/15 Back to IV Chemo
6/15 Avastin
9/15 In Clinical Trial
7/13 colon surgery
9/13 Folfox
11/13 Xeliri
3/14 more liver mets
4/14 Lung Met
4/14 Liver resect delayed;lung resect done
5/14 Surg not an option
9/14 Stivarga
3/15 Back to IV Chemo
6/15 Avastin
9/15 In Clinical Trial
Re: Rovalpituzumab
This. Is Abbvie's Rova-T antibody drug conjugate drug which they are primarily targeting for Small Cell Lung Cancer, a particularly difficult cancer to treat. About 18% of the people that stayed with the drug and we're able to be evaluated saw tumor regression. Many more saw stable disease. It targets a tumor cell surface protein called DLL3 in the notch pathway, and the conjugated drug is toxic and can kill the cancer. I think this is very new attempt to use this to target CRC.
Regards
GrouseMan.
Regards
GrouseMan.
DW 53 dx Jun 2013
CT mets Liver Spleen lung. IVb CEA~110
Jul 2013 Sig Resct
8/13 FolFox,Avastin 12Tx mild sfx, Ongoing 5-FU Avastin every 3 wks.
CEA: good marker
7/7/14 CT Can't see the spleen Mets.
8/16/15 CEA Up, CT new abdominal mets. Iri, 5-FU, Avastin every 2 wks.
1/16 Iri, Erbitux and likely Avastin (Trial) CEA going >.
1/17 CEA up again dropped from Trial, Mets growth 4-6 mm in abdomen
5/2/17 Failed second trial, Hospitalized 15 days 5/11. Home Hospice 5/26, at peace 6/4/2017
CT mets Liver Spleen lung. IVb CEA~110
Jul 2013 Sig Resct
8/13 FolFox,Avastin 12Tx mild sfx, Ongoing 5-FU Avastin every 3 wks.
CEA: good marker
7/7/14 CT Can't see the spleen Mets.
8/16/15 CEA Up, CT new abdominal mets. Iri, 5-FU, Avastin every 2 wks.
1/16 Iri, Erbitux and likely Avastin (Trial) CEA going >.
1/17 CEA up again dropped from Trial, Mets growth 4-6 mm in abdomen
5/2/17 Failed second trial, Hospitalized 15 days 5/11. Home Hospice 5/26, at peace 6/4/2017
Re: Rovalpituzumab
thanks Grouse. They tested me for DLL3 and I did decide against it as there was a good chance of adema on the lungs and mine are already tumor compromised.
6/13 Age 45 mom of 11 and 13 yr old DX Stage IV liver mets
7/13 colon surgery
9/13 Folfox
11/13 Xeliri
3/14 more liver mets
4/14 Lung Met
4/14 Liver resect delayed;lung resect done
5/14 Surg not an option
9/14 Stivarga
3/15 Back to IV Chemo
6/15 Avastin
9/15 In Clinical Trial
7/13 colon surgery
9/13 Folfox
11/13 Xeliri
3/14 more liver mets
4/14 Lung Met
4/14 Liver resect delayed;lung resect done
5/14 Surg not an option
9/14 Stivarga
3/15 Back to IV Chemo
6/15 Avastin
9/15 In Clinical Trial
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