Immunotherapy for LIVER METS -Trial, several locations

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Maia
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Immunotherapy for LIVER METS -Trial, several locations

Postby Maia » Tue Feb 14, 2017 8:37 am

Safety Study of Talimogene Laheraprepvec Injected Into Hepatocellular Carcinoma and Metastatic Liver Tumors
#NCT02509507

*Trial for liver mets
*Talimogene laherparepvec (T-VEC) injected intrahepatically, into liver tumors, included metastases from CRC.

*Several locations: California, Kentucky, Missoury,New Jersey, Spain, Switzerland.

*Liver tumors must not be estimated to invade approximately more than one-third of the liver.
*Must have measurable liver tumors that are suitable for injection.
*Adequate hematological, renal, hepatic and coagulation function is required.

More info on the trial page https://clinicaltrials.gov/ct2/show/NCT02509507

Important: T-VEC is an APPROVED, SINCE 2015, IMMUNOTHERAPY FOR MELANOMA LESIONS. Very well known agent.
IMLYGIC® (talimogene laherparepvec) was the first oncolytic viral therapy approved in US, in 2015, for melanoma. Intratumoural injection on lesions.
"Talimogene laherparepvec (T-VEC) produced (Amgen) is a drug created from a genetically modified herpes virus, allowing it to not only directly attack the cancer cell, but to change the DNA of a tumor cell as well. The genetic modification to the tumor causes it to excrete a continuous stream of GM-CSF, an immune system "emergency signal." This attracts T-cells to the tumor in large numbers for as long as the tumor exists. As a treatment T-VEC has an impressive safety profile."

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