ASK YOUR ONC TO CHECK FOR MSS/MSI STATUS ASCO GI 2017 (ongoing now, Jan 21-22)

[Maia]

Just some hours ago, at ASCO GI cancers 2017:


"The evidence is convincing that MSI-High patients with metastatic disease get benefit from new checkpoint inhibitors" and in fact they are an option, according with the NCC [National Comprehensive Cancer Network] guidelines.
"We check for MSI status inmmediatly in patients with metastatic disease"
"If I had metastatic colon cancer with MSI-High, I might prefer a checkpoint inhibitor upfront".

Alan P. Venook, MD of the University of California San Francisco, describes which colorectal patients will benefit the most from immunotherapy at the present.

http://www.oncologytube.com/video/which ... y/10000608
ASCO GI2017
01/21/17

This is a recording: find out your microsatellite status (MSS or MSI)... beep...

[Lee]

Just bumping back up to the top

And to add, THANK YOU Maia for all the research and help that you offer to this forum. You are a true asset around here.

Lee

[Maia]

I'm a true broken record LOL

[TXLiz]

This is relevant to my interests. I am MSI high and at my last onky appt. I asked him about immunotherapy.

He wants me to finish my folfox and see how I am when it's done. I go to MD Anderson for a follow up in April and def will chat with them about this issue.

Thanks for the info!

[Maia]

Happy to hear it might help you, Liz!

[cmrl]

I'm just wondering if health insurance will agree to pay for this test since I'm 3+1/2 years out from surgery and NED. Actually, I have some lung nodes they are watching, so I would like to be prepared. I guess they still have samples of my tumor stored. I recall agreeing they could use it for research, so you would think it was already tested.
I'm just not sure how to approach my Oncologist to get this done.

[Maia]

Many people go back to their reports to find out that the test was actually performed, sometimes at diagnosis. It's just it was not so significant, clinically, years ago (it was only significant for those too young, with a history of cancer in the family, to rule out/ determine Lynch syndrome).
So, maybe the best approach is just contact your doctor and say the truth: I've followed the news from the ASCO Gastrointenstinal Symposium this past week end and found out that knowing the MSS/ MSI status is very important for further treatment, with immunotherapy, do we know my microsatellite (MS) status, is it in the old report? (if you email him/her, send the video link, surely it'll be appreciated).

[Maia]

Bumping for AnneClare (and everyone diagnosed years ago or over 50).
Ask to know your MS status! It's the new recommendation --all CRC patients should be tested to determine if they are MSS or MSI!

[Maia]

More recent news:

Atezolizumab/Bevacizumab Combo Attains 90% DCR in MSI-High mCRC
Published Online: Tuesday, Feb 07, 2017
- See more at: http://www.onclive.com/web-exclusives/a ... SQYED.dpuf

ADDING Avastin (bevacizumab) to Keytruda seems to pack an even greater punch for MSI-H / Lynch. Combo of anti PD-1/PD-L1 (Keytruda, Opdivo, atezo, durva, etc.) plus Avastin. See the trial Stephen is on viewtopic.php?f=1&t=51990

Could this be added motivation to find out your MS status (MSS / MSI) if you haven't yet.

http://fightcolorectalcancer.org/blog/t ... ot-part-1/
http://fightcolorectalcancer.org/blog/t ... ot-part-2/