I have two things that help.
On day one and two of the Folfiri cycle I'll take Olanzapine with the zofran to knock out the nausea. I'll usually take something for pain too. The Olanzapine makes me fall asleep for several hours with no nausea. It can be taken more often than the zofran so you can keep ahead of the nausea.
I don't take this on day three because I have to be awake to get my pump disconnected.
I also take an an anti-anxiety med before infusion and as I am leaving the infusion center. It's funny but I can get nauseous just thinking about going to chemo, and the long drive home from chemo. When I have less anxiety I have less nausea.
I hope this helps.
Female age 39- ,2 teens.
Colon Cancer - DX March 2013
Age 34 at DX - Stage III B
Resection surgery -May 2013
FOLFOX - June, 2013 to Sept, 2013
5FU plus leukavorin Sept, 2013 to Dec, 2013
METs liver and lungs discovered Sept, 2015
KRAS - MSS
FOLFIRI plus Avastin - Sept, 2015 - July 2017
Durvalumab and Cediranib Sept 2017 Dec 17
FOLFOX with desensitization protocol - current