A DK37 CURATED MSS-CRC CLINICAL TRIAL FINDER!

[DK37]

DK - Thanks for this - I took a look at the site today attempting to locate a few options for my wife, now that she has failed her first trial (Iri, Erbitux and Avastin) A 20% growth (4 to 6 mm) in 2 of them over a period of 9 months which is the criteria for failure. They were small to begin with. I see a few trials you list I may attempt to investigate further. She is MSS-CRC and all mets other than the ones in her abdomen are stable and under control (calcified or gone). She only has 4 or 5 I think she said and the biggest is pressing against her ureter between kidney and bladder. They are not all that big yet. Any trials on your priority list?

Regards,

GrouseMan

Hi GrouseMan-

Sorry to hear about your wife's progression on her past trial, I sincerely hope the trial finder can help you find the next trial. It is heavily biased towards immunotherapy trials, so just a repeat that it does not show every possible CRC trial out there.

"In general" (purely as scientific educated guess - I don't have a crystal ball to tell the future in general or what trial will work for a particular patient), since MSS-CRC is so immunologically cold, I am currently leaning towards trials: that are either 1.) more "brute force" and less impacted by a cold tumor environment (like some of the bifunctional trials) and 2.) trials that actively via MoA try to convert cold MSS-CRC tumors into hot tumors prior to PD1 inhibitor therapy. That is the mechanistic basis for the trial I signed up for myself ( NCT02636036) - which is designed to use an oncolytic virus to heat up a tumor and then hit it with a PD1 inhibitor (and this trial has a site near you in Detroit), As I posted about previously, I also am intrigued by the published Phase 1 results of the repurposed AIDS-drug Maraviroc - although that would need to be tried (under the supervision of your oncologist!!) via off-label use since there is not currently a CCR5 antagonist inhibitor trial running in the US.

All the best to you and your wife,
-DK

[DK37]

Five days and ~700 users later… we’re ready for our next MSS-CRC CURATED CLINICAL TRIAL LIST UPDATE!

Available at http://colorectalmsstrials.org/

For those wanting more info: to repeat a few special notes below.

1.) Web browser app: http://bit.ly/2jaj7tc Make sure to click on “Update Data” on the bottom to insure you have the latest version.
Phone app installer: http://bit.ly/2iIW5Jv If you get a blank page, instead of clicking on this link, copy & paste it into your phone’s web browser.

2.) In the “Instructions/How to” tab of the app is the web address to download a PDF version of the trial list. Here is the web link also: https://drive.google.com/open?id=0Bwc5k ... C1kN2pzOFU

3.) Trials added this update: NCT02991196, NCT02517398, NCT02904226, NCT02928224, NCT01376505, VAPER vaccine trial (United Kingdom)

A commonly used feature of the App is to search by State (or country) name – this narrows down the large list of MSS-CRC eligible trials to trials only in the states/countries you are interested in (usually a much shorter list)

A special column determines if prior exposure to PD-1 inhibitors is OK for trial inclusion to aid trial order strategy. These trials can be identified with the search box term “PD1-OK”

There are hyperlinks within the list to printable pages from your browser of both the clinicaltrials .gov record as well as: a single page “info sheet” for the trial and scientific publications.

IMPORTANT disclaimers and explanations of what parameters are used to generate this CURATED list are in the App under the “Disclaimer & Important Info" and the "Instructions / How to" tabs (to see this tabs, click on the icon –three little lines– on the left upper corner).

- This list of trials is NOT medical advice - this list is intended to be an information resource to facilitate discussions with your MD/medical team

- The trials are NOT listed in suggested "rank order"

- If you want a non-curated list of trials to show more complete & extensive lists of CRC trials, I suggest using these trial finders:

• Colon Cancer Alliance CRC Trial Finder: http://www.ccalliance.org/get-support/clinical-trials/

• Cancer Research Institute/Emerging Med Immunotherapy Trial Finder: https://platform.emergingmed.com/find-c ... artnerhome

For missing trials or feedback about the app, send information to No.Deer.Here.37@gmail.com...

[Brikee]

Sorry I'm a bit of a newbie but what was MSS stand for? Microsatellite stable? My husband's foundation one report under 'Additional Findings' has the line:
Microsatellite status - MS-Stable.

Does that mean he might be eligible for immunotherapy? Thanks!

[Maia]

Yes, MSS means "Microsatellite stable". MSI means "Microsatellite INstable".
ALL CRC patients are eligible for immuntherapy.For those MSI (specially, MSI-High), there are encouraging results from just certain immunotherapies as single agents (just one drug) at the present; often, oncologists are able to prescribe immuno drugs to them, without being on a clinical trial. For those MSS, there are ongoing clinical trials and we start to see some good responses. MSI responds easier to immunotherapy than MSS, *to the present*. For MSS, immunotherapies that work will be for sure a combination of agents.
Because MSS trials are a higher need, that curated file was created by Tom (our fellow DK37, who is a stage IV patient and also a scientist).

[Brikee]

Yes, MSS means "Microsatellite stable". MSI means "Microsatellite INstable".
ALL CRC patients are eligible for immuntherapy.For those MSI (specially, MSI-High), there are encouraging results from just certain immunotherapies as single agents (just one drug) at the present; often, oncologists are able to prescribe immuno drugs to them, without being on a clinical trial. For those MSS, there are ongoing clinical trials and we start to see some good responses. MSI responds easier to immunotherapy than MSS, *to the present*. For MSS, immunotherapies that work will be for sure a combination of agents.
Because MSS trials are a higher need, that curated file was created by Tom (our fellow DK37, who is a stage IV patient and also a scientist).

Thank you for the prompt response Maia! You, Tom and others that have contributed to this project are amazing.

[.jim.]

This might be a trial to add to the spreadsheet:

CAR-T Hepatic Artery Infusions for CEA-Expressing Liver Metastases

Only for those with liver mets, though.

[Maia]

This might be a trial to add to the spreadsheet:

CAR-T Hepatic Artery Infusions for CEA-Expressing Liver Metastases

Only for those with liver mets, though.

It is in the spreadsheet (maybe you have an older version). Check the trial finder (link in my signature), put CAR in the search box, and you will see it : )
It's a great trail, an "oldie" in this forum (several persons went for it in this forum, years ago)

[.jim.]

oops! will have to search the spreadsheet more carefully!

[Maia]

Just bumping this post to mention many more trials have been added this past Feb 4, 2017:

New or updated Trials this update:NCT02959437, NCT02994953, NCT01851369, NCT03030378, NCT02060188 (Cobi + PD1 + CTLA-4 Phase 2), NCT02658890, NCT03010176, NCT02448173 (STAGE 2 patients – Phase 3 trial randomized surgery vs. surgery + vaccine on recurrence), NCT02718911, NCT02499328, NCT03007407, NCT03005002, NCT02617277

MSS-CRC Clinical Trial Finder Web/Phone App at: http://colorectalmsstrials.org/

[inorganic8]

One of these trials may be perfect for my husband. I am in contact with MSK.

Thank you, thank you, thank you for doing this. Thank you a thousand more times.

[Maia]

Best of lucks, inorganic8.
I'll let DK37 (Tom) know your words, they will cheer him up : )

[DK37]

HI Everyone,

FYI Maia and I did a major update of the curated MSS-CRC Clinical Trial Finder App, there have been a lot of new trials registered lately!

http://colorectalmsstrials.org/

Of note: not a single new trial excludes for prior PD-1 inhibitor use – so as predicted/hoped – I think that old strategic complication is definitely on the way out the door for most trials – a very good thing!

Below is a list of the NCT# that were added (most) or info changed on (a few). To make sure you have the updated data, the next time to start up the App, click on the “UPDATE DATA” button on the middle bottom of the trial list page.

Here is a link to the PDF version of the current trial list – you’ll see it is getting quite long now. https://drive.google.com/open?id=0Bwc5k ... 0JHV0Y5cjQ

There are many more trials now that MSS-CRC patients (in general) are eligible for if they meet the other criteria, even after my curation pruning – great to see!

OF NOTE TO INTERNATIONAL MEMBERS: There were quite a few European and Asian sites added in this update! In terms of Asia, we try to cover all countries except for China.

Trial NCT list: NCT02509507, NCT02675439, NCT02740270, NCT02947165, NCT02757391, NCT02900664, NCT01351103, NCT02890069, NCT02829723, NCT03043313, NCT02869217, NCT0305220, NCT02929862, NCT03030378, NCT02963831, NCT02151448, NCT03018405, NCT02291614

Cheers, -DK