I am not sure, if I should be posting my thoughts about clinical trials after all my favorite people posted their extremely positive attitude to them. But then, if no one has a different opinion, people who are not as well informed as our "oldest" members, might see clinical trials as an option that should be pursued, no matter what time, pain, suffering and terrible complications, including death, it involves. Time is an essence for stage 4 fellows, unfortunately... Too many deaths in clinical trials and after them too, unfortunately... Too many life threatening complications, unfortunately... There are articles on internet with headings something like "truth about clinical trials" - everyone should read them before making their choice...
So, if time is an essence for us, stage 4 patients, we have to think also how we would like to spend that time after all other tortures we have been thru already.... Yes, thanks God Sleen is well, but how many people on our board went into trials without results and are dead now? And how many are well? 2? Who spent their time better - Frenchie or Karen, who also were on TIL's with Sleen? I am categorically against chemo for life protocols, but for some people, like BB, it works - again, very rare occasion, and I think, it is mostly thanks to his bike mileage and surprising compatibility with his chemo. With clinical trials I am not so much against participating in them, but just want people to realize the real picture - as Tom mentioned, the chances are very low, I would say miserable, not low...Do not go far, just look - Sleen was the only one succeeded with MSS-CRC, and it was such a huge deal that it was posted in NY Times or wherever, I did not read that article, since I know the story....
Another thing is doing trials for the humanity benefits - yes, if you want to benefit humanity this way, it's a go. And many people do them for this reason, God Bless them... But going into trial without realizing your real chances (close to zero) and knowing the results of all the trials designed for MSS/CRC in the past 3-4 years - no results in any of them, but this one case with Sleen - seems to me really disrespectful to the time you have left on this Earth.... I know, I will be crucified here for my opinion, but it is just my opinion and may be it will make people, who place too much hope in clinical trials, to think twice before enrolling...
Sorry, guys, just do not kill me for all the above
11/2005 CC stage 1, F,50yo@dx
Mod dif adenocar, MSS, APC, TP53, CEAs1.6-4.8
1/12 1met liver@Vena Cava, RFA, 3oxi,11 5FU
8/13 2 mets same place,SBRT
4/14 2 Xeliri+Avastin
5/14 Nano Knife liver same 2 mets
6/14 2 Xeliri, ADAPT
4/15 PET, 2 same mets,Cryo Liver
5/15 MJ Oil, Herbs, Suppl, ADAPT
10/15 PET, same area, doubled in size, high SUV
10/15 RH, HAI, visceral involv., no LN
2/16 red FF, 50% red dose FUDR, CEA trends up
3/16 CT, PET, MRI L.Lobe all in small tumors
4/16 No acceptable options, going home