Trial drug - Selinixor (KPT 330)

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Maia
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Re: Trial drug - Selinixor (KPT 330)

Postby Maia » Wed Mar 08, 2017 4:57 am

Oh, yes, that sounds like a good plan that your doctor has, I meant! Lonsurf is usually well tolerated and do has some activity, so hopefully you will recover from it. And then, you'll have there some immunos to try, for hopefully a durable response. Hang in there!

takemeom
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Re: Trial drug - Selinixor (KPT 330)

Postby takemeom » Sun Mar 12, 2017 3:48 pm

Maia wrote:ramg, hope the Lonsurf gives you good results to get you out of the present situation. It's very logic from your doctor to recommend that now. BUT the trial he's proposing you is immunotherapy (that you haven't had until now), a very good combination.
The drug is PDR001 (not PDR101). It's just the anti PD-1 from Novartis (similar to Opdivo and Keytruda). You see less data/ no data on it because that company got later in the "race", that is all. So they are making their bets on combinations. And all of the ones in this trial are very good ones:

The trial is

"A Study of PDR001 in Combination with CJM112, EGF816, Ilaris® (Canakinumab) or Mekinist® (Trametinib)
*# NCT02900664
*Arms specific for CRC (only MSS)
*Combination: PD-1 checkpoint inhibitor (PDR001) + other four agents with immunomodulatory activity (one of them)
https://clinicaltrials.gov/ct2/show/NCT02900664
*_Four_arms_for_CRC. Non randomized. According to tumour characteristics/mutations, CRC patients are assigned to one of the following combinations:
** aPD-1 +canakinumab (Ilaris ; anti IL-1β (monoclonal antibody targeted to interleukin-1 beta), FDA approved anti-Inflammatory, injection)
** aPD-1 + CJM112 (monoclonal antibody targeted to interleukin-17)
** aPD-1 +trametinib (Mekinist; MEK inhibitor, FDA approved, oral)
** aPD-1 + EGF816 (mutant-selective EGFR tyrosine kinase inhibitor; oral)
*Recruiting
* Tennessee, Texas, Belgium, Canada, Singapore, Spain

(I put in bold the trial your doc was thinking to include you in).

Other trial that you have in Singapore is other with the same drug, in other combination:

-----------

"Phase I/Ib Study of GWN323 Alone and in Combination With PDR001 in Patients With Advanced Malignancies and Lymphomas"
# NCT02740270
https://clinicaltrials.gov/ct2/show/NCT02740270
*Combination (PD-1 checkpoint inhibitor (PDR001) + anti-GITR GWN323 ) and monotherapy (anti-GITR alone)
*Advanced malignancies
* Recruiting
* Illinois (U. Chicago), Massachusetts (Dana Farber), New York (MSK), Texas (MD Anderson), Canada, Israel, Singapore, Spain

Both trials have a lot of rationale, in its mechanism of action, for CRC.





my doc just suggested the trial, as vectibix stopped working, i called and was told the triAL was closed
dx 2012 thru routine colonoscopy
lar sept 2012 stage iv
5fku 8 rounds
december 2014 bronchoscopy
mcrc to lymphs around lungs
feb 2015 xeloda
june 2016 interstitial infiltrate, mets in lungs
august 2016 vectibix

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Maia
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Joined: Fri Aug 24, 2012 8:00 am

Re: Trial drug - Selinixor (KPT 330)

Postby Maia » Sun Mar 12, 2017 4:07 pm

takemeom wrote:my doc just suggested the trial, as vectibix stopped working, i called and was told the triAL was closed


*Which* trial are you referring to, takemeom? You quote the two I posted about #NCT02900664 and #NCT02740270.
Sorry Vectibix stopped working. Are you looking for trials in a specific area (State)?

takemeom
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Joined: Sun Oct 14, 2012 2:07 pm
Facebook Username: chia.rose

Re: Trial drug - Selinixor (KPT 330)

Postby takemeom » Mon Mar 20, 2017 2:50 pm

Yes I think that was one of the trials, it was an immunology trial.
Now I am learning about trials, very complicated.
I thought my doc was researching, but it seems they are not, and want me on lonsurf
Lonsurf seems like a general chemo drug, which I have had enough of
Right now I am detoxing from the vectibix, my skin is the worse its been, very dry
I can go anywhere for a trial, I spoke to ask Sarah, in Nashville
dx 2012 thru routine colonoscopy
lar sept 2012 stage iv
5fku 8 rounds
december 2014 bronchoscopy
mcrc to lymphs around lungs
feb 2015 xeloda
june 2016 interstitial infiltrate, mets in lungs
august 2016 vectibix

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Maia
Posts: 2432
Joined: Fri Aug 24, 2012 8:00 am

Re: Trial drug - Selinixor (KPT 330)

Postby Maia » Mon Mar 20, 2017 9:16 pm

If you can go to Sarah Cannon, you'll be more than good advised about immunotherapy trials. They have several for whom you might qualify. :)

takemeom
Posts: 16
Joined: Sun Oct 14, 2012 2:07 pm
Facebook Username: chia.rose

Re: Trial drug - Selinixor (KPT 330)

Postby takemeom » Tue Apr 04, 2017 3:14 pm

yes i have found sarah canon to be very helpful, but
i don't think i can commit to flying there every week with a connection in charlotte
i could miss an appointment
i am trying yale, and trying to get someone in florida to make me an appointment
it is very confusing as i find a trial, then its filled
dx 2012 thru routine colonoscopy
lar sept 2012 stage iv
5fku 8 rounds
december 2014 bronchoscopy
mcrc to lymphs around lungs
feb 2015 xeloda
june 2016 interstitial infiltrate, mets in lungs
august 2016 vectibix

ACPdiddy
Posts: 28
Joined: Wed Apr 12, 2017 4:01 pm
Facebook Username: Albert Pierce

Re: Trial drug - Selinixor (KPT 330)

Postby ACPdiddy » Wed Apr 12, 2017 4:40 pm

Where would it be easier for you to go for trials? I have a long list of my "top trials" for the next time I have to find a new treatment option.
I could check my list for you and post some possibilities.
I'll try to pick things that might have milder side effects. Any other requests, or info I should know?
Apologies if this is bad form. I'm new here.


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