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Re: ***News Stories Thread*** ONGOING 2017

Posted: Mon Aug 28, 2017 4:56 am
by Maggie Nell
Our team here in the Department of Gastroenterology, Monash University, recently confirmed the effectiveness of lowering FODMAP content in the diet on symptom relief for individuals with IBS. This project was part of the PhD work conducted by Emma Halmos.

In a well-controlled study, 30 individuals with IBS were fed both a typical Australian diet and a diet low in FODMAPs (≤3 g/day) for 3 weeks in a blinded manner so not to influence their judgement on symptom improvement. Overall IBS symptoms were reduced by 50% on the low FODMAP diet, with the greatest improvement occurring one week after implementing the diet. Similar improvements were also seen for abdominal pain, bloating, wind and dissatisfaction with stool consistency, demonstrating the first-ever, highest quality evidence that diet can be used successfully to treat this condition.


http://fodmapmonash.blogspot.com.au/201 ... .html#more


Thought I would place this link here for people who are having issues with digestion after their surgeries or would like
some new recipes or a heads-up on what our scientists get up to in Melbourne.

Re: ***News Stories Thread*** ONGOING 2017

Posted: Wed Aug 30, 2017 8:15 pm
by NHMike
Novartis’ CAR-T gene therapy, the first approved by FDA, to cost $475,000

Novartis AG’s CAR-T cell therapy was approved by the Food and Drug Administration on Wednesday, making it the first gene therapy to be available in the U.S.

Novartis’ NVS, -1.05% Kymriah was approved for young people up to age 25 with a form of acute lymphoblastic leukemia (ALL).


It's not colon cancer but I think that the approach could be used for specific colon cancers. It also provides an idea as to the relative cost of drugs that have to be custom made for each patient. I expect that cost to come down over time as technology to eventually automates more and more of the process. Of course I wish that this stuff were here right now.

Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, ...

Posted: Wed Sep 06, 2017 1:44 pm
by mpbser
An oldie but a goodie:

http://www.cell.com/cell-metabolism/ful ... 50-4131(14)00062-X?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS155041311400062X%3Fshowall%3Dtrue

I think you have to copy and paste the whole URL

(( edited URL linked below -CRguy))
Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population

Keep colon cancer at bay: What to eat and what to avoid

Posted: Mon Sep 11, 2017 12:40 am
by JJH

FDA approves first biosimilar for the treatment of cancer

Posted: Sat Sep 16, 2017 1:40 pm
by JJH
FDA approves first biosimilar for the treatment of cancer
https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm576112.htm
Mvasi, a biosimilar to the cancer drug Avastin, is approved for certain colorectal, lung, brain, kidney and cervical cancers

Chemotherapy eating bacteria defend cancer

Posted: Sat Sep 16, 2017 3:43 pm
by CRguy
The discovery : Chemotherapy eating bacteria defend cancer
Researchers have found that bacteria live inside cancerous tumours they've studied, and these bacteria can suck in and neutralize a common chemotherapy drug, effectively defending the cancer against our medications.

Research paper abstract link Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine

Scientists unlock a key to why cancer spreads

Posted: Sat Sep 16, 2017 3:48 pm
by CRguy
Scientists unlock a key to why cancer spreads
When we fight cancer, we usually target those tumours — with radiation, surgery or chemo — hoping to get at the cancer before it spreads and becomes uncontrollable. But a team of American researchers is developing a new strategy. They're not targeting the tumour. Instead, they're targeting the spread — hoping to slow it down or stop it, right in its tracks.


Research Paper link Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration

Re: ***News Stories Thread*** ONGOING 2017

Posted: Mon Sep 18, 2017 8:30 pm
by NHMike
WSJ: A Question for Anyone Getting an MRI
Patients need to know if the doctor plans to use contrast, or gadolinium, because it may leave harmful metal deposits; a new FDA warning

Magnetic resonance imaging with a gadolinium-based contrast agent, called a GBCA, leaves metal deposits in the body’s organs and tissues including the brain, research shows. Scientists are exploring whether the deposits harm patients.

Gadolinium is a metal dye injected into the veins to help radiologists better read an MRI scan. The dye is used, experts estimate, in as many as half of the millions of MRIs performed annually in the U.S., generally for scans that are looking for tumors, severe inflammation or blood vessels. Doctors say the dye makes it possible to detect and diagnose more detail. MRIs to look at bone and joint issues don’t need a contrast agent for doctors to make a diagnosis.

https://www.wsj.com/articles/a-question ... 1505751710

It's behind a paywall but there may be similar articles that aren't.

MRI contrast Gadolinium Toxicity

Posted: Mon Sep 18, 2017 9:33 pm
by CRguy
Further articles on Gadolinium Toxicity including open source links as noted in the prior post.

Recent summary of FDA Viewpoints

Re: Scientists unlock a key to why cancer spreads

Posted: Tue Sep 19, 2017 5:30 am
by -Mar5-
CRguy wrote:Scientists unlock a key to why cancer spreads
When we fight cancer, we usually target those tumours — with radiation, surgery or chemo — hoping to get at the cancer before it spreads and becomes uncontrollable. But a team of American researchers is developing a new strategy. They're not targeting the tumour. Instead, they're targeting the spread — hoping to slow it down or stop it, right in its tracks.


Research Paper link Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration


Is this the same as immunotherapy which is similar to that effective Melanoma treatment ?

No, that appears to use more standard use immuno agents on the primary tumors not the signaling for migration.
The above referenced paper is early lab research in need further testing and clinical trials - CRguy

'Dr. Google' made me worry about colon cancer. Did I overreact?

Posted: Fri Sep 22, 2017 3:27 am
by JJH

Re: ***News Stories Thread*** ONGOING 2017

Posted: Sat Sep 23, 2017 1:55 am
by Maggie Nell
New social and economic questions also arise. Should you keep trying to fulfill your ambitions, to build and compete?
Will telling your friends and coworkers that you have cancer adversely affect your prospects for success? How should
you protect your family from financial disaster? How do you emerge from the loneliness that seems to accompany
illness and find meaning within your silent universe?


http://med.stanford.edu/survivingcancer ... -fear.html

http://med.stanford.edu/survivingcancer ... right.html


“... when you look at the maze you start from the top and go into the maze ... your life, you go down and then you reach a
place where you have to turn around ... maybe in your own life you fall, something happens in your home, you are sad,
you pick yourself up and you go on through the maze ... you go on and on and on ...


http://med.stanford.edu/survivingcancer ... oping.html

Re: ***News Stories Thread*** ONGOING 2017

Posted: Tue Sep 26, 2017 3:10 pm
by NHMike
The humanitarian crisis for Puerto Ricans is dire, with the electrical system decimated and the majority without access to safe drinking water, but few may realize how the hurricane's effects on the island have the potential for far-reaching public health implications on the U.S. mainland and around the world.



https://www.forbes.com/sites/davidkroll ... fa413e3f5d

How people under 50 can protect against colon cancer

Posted: Thu Sep 28, 2017 1:31 pm
by JJH

Colon cancer mortality rates climb — but only among whites

Posted: Sat Oct 07, 2017 4:39 am
by garbovatwin