***News Stories Thread*** ONGOING 2017

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Maggie Nell
Posts: 621
Joined: Wed May 27, 2015 1:57 am
Location: Melbourne, Australia

Re: ***News Stories Thread*** ONGOING 2017

Postby Maggie Nell » Mon Aug 28, 2017 4:56 am

Our team here in the Department of Gastroenterology, Monash University, recently confirmed the effectiveness of lowering FODMAP content in the diet on symptom relief for individuals with IBS. This project was part of the PhD work conducted by Emma Halmos.

In a well-controlled study, 30 individuals with IBS were fed both a typical Australian diet and a diet low in FODMAPs (≤3 g/day) for 3 weeks in a blinded manner so not to influence their judgement on symptom improvement. Overall IBS symptoms were reduced by 50% on the low FODMAP diet, with the greatest improvement occurring one week after implementing the diet. Similar improvements were also seen for abdominal pain, bloating, wind and dissatisfaction with stool consistency, demonstrating the first-ever, highest quality evidence that diet can be used successfully to treat this condition.


http://fodmapmonash.blogspot.com.au/201 ... .html#more


Thought I would place this link here for people who are having issues with digestion after their surgeries or would like
some new recipes or a heads-up on what our scientists get up to in Melbourne.
DX April 2015, @ 54
35mm poorly diff. tumour found upon emergency r. hemicolectomy
for ileo-colic intussusception.
Lymph nodes: 0/22
T3 N0 MX

NHMike
Posts: 326
Joined: Fri Jul 21, 2017 3:43 am

Re: ***News Stories Thread*** ONGOING 2017

Postby NHMike » Wed Aug 30, 2017 8:15 pm

Novartis’ CAR-T gene therapy, the first approved by FDA, to cost $475,000

Novartis AG’s CAR-T cell therapy was approved by the Food and Drug Administration on Wednesday, making it the first gene therapy to be available in the U.S.

Novartis’ NVS, -1.05% Kymriah was approved for young people up to age 25 with a form of acute lymphoblastic leukemia (ALL).


It's not colon cancer but I think that the approach could be used for specific colon cancers. It also provides an idea as to the relative cost of drugs that have to be custom made for each patient. I expect that cost to come down over time as technology to eventually automates more and more of the process. Of course I wish that this stuff were here right now.
Mike in NH:
Rectal Bleeding biopsy June 23, 2017, Diagnosed Stage 3B rectal cancer late July 2017 via MRI.
T3, N1b, M0.
Chemo (Xeloda) and radiation from 07/31/17 to 09/08/17.
CEA before treatment: 2.7. CEA after 14 treatments 1.9 to 1.8 after treatment.
KRAS Mutant KRAS p.Gly12Asp

mpbser
Posts: 251
Joined: Wed Apr 19, 2017 11:52 am

Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, ...

Postby mpbser » Wed Sep 06, 2017 1:44 pm

An oldie but a goodie:

http://www.cell.com/cell-metabolism/ful ... 50-4131(14)00062-X?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS155041311400062X%3Fshowall%3Dtrue

I think you have to copy and paste the whole URL

(( edited URL linked below -CRguy))
Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population
Wife 4/17 Dx age 45
5/17 - Lap left hemi
Adenocarcinoma
5 x 4 x 1 cm
low grade
T3 N2b M1a
Stage IV A
lymph nodes: 9 of 54
8/17 Sub-total colectomy
2nd tumor 5.5 cm width T1 N0
CEA: 1.4 Pre-op; 2.1 2 days Post-op
MSS/MSI-L
Lynch no; KRAS wild
Immunohistochemsistry: Normal expression of MLH1, MSH2, MSH6, and PMS2
Tumor DNA variants: MTOR, APC, TP53

JJH
Posts: 130
Joined: Mon Apr 24, 2017 7:26 am
Location: Europe

Keep colon cancer at bay: What to eat and what to avoid

Postby JJH » Mon Sep 11, 2017 12:40 am


JJH
Posts: 130
Joined: Mon Apr 24, 2017 7:26 am
Location: Europe

FDA approves first biosimilar for the treatment of cancer

Postby JJH » Sat Sep 16, 2017 1:40 pm

FDA approves first biosimilar for the treatment of cancer
https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm576112.htm
Mvasi, a biosimilar to the cancer drug Avastin, is approved for certain colorectal, lung, brain, kidney and cervical cancers

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CRguy
Posts: 9166
Joined: Sun Feb 10, 2008 6:00 pm

Chemotherapy eating bacteria defend cancer

Postby CRguy » Sat Sep 16, 2017 3:43 pm

The discovery : Chemotherapy eating bacteria defend cancer
Researchers have found that bacteria live inside cancerous tumours they've studied, and these bacteria can suck in and neutralize a common chemotherapy drug, effectively defending the cancer against our medications.

Research paper abstract link Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine

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CRguy
Posts: 9166
Joined: Sun Feb 10, 2008 6:00 pm

Scientists unlock a key to why cancer spreads

Postby CRguy » Sat Sep 16, 2017 3:48 pm

Scientists unlock a key to why cancer spreads
When we fight cancer, we usually target those tumours — with radiation, surgery or chemo — hoping to get at the cancer before it spreads and becomes uncontrollable. But a team of American researchers is developing a new strategy. They're not targeting the tumour. Instead, they're targeting the spread — hoping to slow it down or stop it, right in its tracks.


Research Paper link Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration

NHMike
Posts: 326
Joined: Fri Jul 21, 2017 3:43 am

Re: ***News Stories Thread*** ONGOING 2017

Postby NHMike » Mon Sep 18, 2017 8:30 pm

WSJ: A Question for Anyone Getting an MRI
Patients need to know if the doctor plans to use contrast, or gadolinium, because it may leave harmful metal deposits; a new FDA warning

Magnetic resonance imaging with a gadolinium-based contrast agent, called a GBCA, leaves metal deposits in the body’s organs and tissues including the brain, research shows. Scientists are exploring whether the deposits harm patients.

Gadolinium is a metal dye injected into the veins to help radiologists better read an MRI scan. The dye is used, experts estimate, in as many as half of the millions of MRIs performed annually in the U.S., generally for scans that are looking for tumors, severe inflammation or blood vessels. Doctors say the dye makes it possible to detect and diagnose more detail. MRIs to look at bone and joint issues don’t need a contrast agent for doctors to make a diagnosis.

https://www.wsj.com/articles/a-question ... 1505751710

It's behind a paywall but there may be similar articles that aren't.
Mike in NH:
Rectal Bleeding biopsy June 23, 2017, Diagnosed Stage 3B rectal cancer late July 2017 via MRI.
T3, N1b, M0.
Chemo (Xeloda) and radiation from 07/31/17 to 09/08/17.
CEA before treatment: 2.7. CEA after 14 treatments 1.9 to 1.8 after treatment.
KRAS Mutant KRAS p.Gly12Asp

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CRguy
Posts: 9166
Joined: Sun Feb 10, 2008 6:00 pm

MRI contrast Gadolinium Toxicity

Postby CRguy » Mon Sep 18, 2017 9:33 pm

Further articles on Gadolinium Toxicity including open source links as noted in the prior post.

Recent summary of FDA Viewpoints

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-Mar5-
Posts: 3
Joined: Tue Sep 19, 2017 5:23 am

Re: Scientists unlock a key to why cancer spreads

Postby -Mar5- » Tue Sep 19, 2017 5:30 am

CRguy wrote:Scientists unlock a key to why cancer spreads
When we fight cancer, we usually target those tumours — with radiation, surgery or chemo — hoping to get at the cancer before it spreads and becomes uncontrollable. But a team of American researchers is developing a new strategy. They're not targeting the tumour. Instead, they're targeting the spread — hoping to slow it down or stop it, right in its tracks.


Research Paper link Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration


Is this the same as immunotherapy which is similar to that effective Melanoma treatment ?

No, that appears to use more standard use immuno agents on the primary tumors not the signaling for migration.
The above referenced paper is early lab research in need further testing and clinical trials - CRguy


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