vilca11 wrote:Good news - my wrinkles on the neck disappeared and skin looks young - great, I will go back HOME in good shape, young and beautiful
So, after a 1.5 years of sleeping in rental beds and travelling between 3 continents with the severe hip contusion and severe neuralgia of cervical spine, speaking foreign language (my Spanish got much better in Spain), I am back home in my Heaven on Earth... I asked if liver failure can happen without symptoms being present (edema, yellow skin, gases, ascites, weight loss, etc) - they do not have end of life care in Ecuador, well, may be in Quito, but not in my mountain region - and yes, it can, unfortunately. So, if it happens to me without symptoms (so far I do not have them), I will be doomed... no real help here... But if I have symptoms first, I will have time to fly to the USA to hospice. I do not know if I have mets in any other places in the body, we did not do PET for the last 8 mo, but it does not matter now. That is the situation.
vilca11 wrote: Too bad Maia still did not forgive me for whatever I did awkwardly say long time ago... I love her and think of her often, please send her my love.
"This study investigates the activity of a new regimen of treatment for patients with metastatic colorectal carcinoma. This includes a combination of well-known chemotherapy agents and anti-inflammatory agents, when administered orally at low daily doses and without planed brakes (Low Dose Metronomic regimen), in contrast with the conventional and already exhausted regimens of treatment at Maximal Tolerated Doses (MTD) which required pre-planned brakes between treatment days."
"Patients suffering from metastases of colorectal cancer whose tumor cells develop resistance to conventionally administered treatments are in need for new methods of treatment.
While their chemotherapy had been administered up till then at the classical regimen of Maximal Tolerated Doses (MTD), which is aimed to directly killing maximal fractions of tumor cells, the present study evaluates the clinical benefit of a treatment which is based on old chemotherapeutic and old anti-inflammatory drugs, when these are administered at low doses,on daily basis and orally taken, without planed brakes (Low Dose Metronomic regimen).
Treatments based on this type of regimen have already been studied on other models of cancer and showed the capacity of suppressing tumor growth by a new category of anti-tumor effects. Namely, by affecting factors and mechanisms which prevail in the microenvironment that surrounds tumor deposits, thus circumventing the resistance of their cancer cells to chemotherapy."
Metronomic, low dose chemotherapy may *restore* sensitivity to already-used chemo agents; may put the immune system back in action, may keep the tumour burden low, even if not eliminating cancer completely, with good quality of life. Even if you have had some of the agents, don't think about the same side effects --it's about doses and schedule. Think of bleach --drinking bleach may be a bad idea, but if you put 2 drops of bleach per 1 liter of water, you have emergency purified water.
And don't think 'I already have failed (X), can't try again', because at a lower dose, the agent works via other mechanisms, so acquired resistance (or plain intolerance) may not be an issue.
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