The Colon Club

Here's an interesting trial that I actually missed until recently.

"A Study of the Safety, Pharmacokinetics, and Therapeutic Activity of RO6958688 in Combination With Atezolizumab in Participants With Locally Advanced and/or Metastatic Carcinoembryonic Antigen (CEA)-Positive Solid Tumors"

https://clinicaltrials.gov/ct2/show/NCT02650713

It is something called a "CEA-CD3 bifunctional" in combination with a PDL1 inhibitor. The CEA it targets is a "membrane-bound" version, not the CEA that is floating around in your blood that everyone here knows is tested with a standard blood test.

The protein binds to CEA on tumor cells and physically pulls CD3 immune cells along with it - that is why it is an experimental strategy for "cold" tumors like MSS-CRC.

There is a safety window concern since CEA is produced by some normal cells - but hopefully they can find a dose that gets around that potential problem.

Cheers,
-DK

Your trial, Tim UK! viewtopic.php?f=1&t=56553&p=447107#p447107
Other person doing well on this same trail at the MSK, 8 weeks into it (but slots on MSK are full by now : ( )

Maia wrote:Your trial, Tim UK! viewtopic.php?f=1&t=56553&p=447107#p447107
Other person doing well on this same trail at the MSK, 8 weeks into it (but slots on MSK are full by now : ( )

As I just said on the other thread - congrats Tim, fantastic news!!!!

-DK

Tim: I sent you a PM.

I was on the list for this trial at Duke. I got the phone call yesterday that my archival specimen tested positive for CEA. The next step is to do a core biopsy to test one of my mets (for CEA). However, I have actually decided not to participate in this trial because it involves a great deal of time commitment: having two core biopsies taken, and weekly infusions of the trial drug. I live alone and don't have support staff to chauffer me around. I am waiting for another trial to open (https://clinicaltrials.gov/ct2/show/NCT02873195) that is much much more doable, given my circumstances, and a Phase 2. I hope I am making the right decision.