MSS-CRC Immunotherapy Trial: CEA-CD3 Bifunctional + PDL1 Inhibitor

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DK37
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Location: San Diego

MSS-CRC Immunotherapy Trial: CEA-CD3 Bifunctional + PDL1 Inhibitor

Postby DK37 » Wed Dec 07, 2016 6:05 am

Here's an interesting trial that I actually missed until recently.

"A Study of the Safety, Pharmacokinetics, and Therapeutic Activity of RO6958688 in Combination With Atezolizumab in Participants With Locally Advanced and/or Metastatic Carcinoembryonic Antigen (CEA)-Positive Solid Tumors"

https://clinicaltrials.gov/ct2/show/NCT02650713

It is something called a "CEA-CD3 bifunctional" in combination with a PDL1 inhibitor. The CEA it targets is a "membrane-bound" version, not the CEA that is floating around in your blood that everyone here knows is tested with a standard blood test.

The protein binds to CEA on tumor cells and physically pulls CD3 immune cells along with it - that is why it is an experimental strategy for "cold" tumors like MSS-CRC.

There is a safety window concern since CEA is produced by some normal cells - but hopefully they can find a dose that gets around that potential problem.

Cheers,
-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
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Maia
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Re: MSS-CRC Immunotherapy Trial: CEA-CD3 Bifunctional + PDL1 Inhibitor

Postby Maia » Wed Dec 07, 2016 6:24 am

Your trial, Tim UK! viewtopic.php?f=1&t=56553&p=447107#p447107 :)
Other person doing well on this same trail at the MSK, 8 weeks into it (but slots on MSK are full by now : ( )

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DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Re: MSS-CRC Immunotherapy Trial: CEA-CD3 Bifunctional + PDL1 Inhibitor

Postby DK37 » Wed Dec 07, 2016 6:55 am

Maia wrote:Your trial, Tim UK! viewtopic.php?f=1&t=56553&p=447107#p447107 :)
Other person doing well on this same trail at the MSK, 8 weeks into it (but slots on MSK are full by now : ( )


As I just said on the other thread - congrats Tim, fantastic news!!!!

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

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ktwmn
Posts: 336
Joined: Tue Aug 02, 2011 9:41 am

Re: MSS-CRC Immunotherapy Trial: CEA-CD3 Bifunctional + PDL1 Inhibitor

Postby ktwmn » Wed Dec 07, 2016 3:22 pm

Tim: I sent you a PM.
Dx 7/11, Stage IIIc CC
12 txs Folfox 8/2011-2/2012
MSS, KRAS-mut G12D
NED until 3/2015, mets to liver and peritoneum
April-December 2015: 15 txs folfiri+avastin
Liver mets resolved; pelvic met remains
January-May 2016: folfox+avastin; allergic rxn to oxi
June-August 2016: 5FU+avastin
October 2016: looking into immuno trial
January 2017: maintenance chemo xeloda + avastin

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ktwmn
Posts: 336
Joined: Tue Aug 02, 2011 9:41 am

Re: MSS-CRC Immunotherapy Trial: CEA-CD3 Bifunctional + PDL1 Inhibitor

Postby ktwmn » Thu Dec 08, 2016 10:47 am

I was on the list for this trial at Duke. I got the phone call yesterday that my archival specimen tested positive for CEA. The next step is to do a core biopsy to test one of my mets (for CEA). However, I have actually decided not to participate in this trial because it involves a great deal of time commitment: having two core biopsies taken, and weekly infusions of the trial drug. I live alone and don't have support staff to chauffer me around. I am waiting for another trial to open (https://clinicaltrials.gov/ct2/show/NCT02873195) that is much much more doable, given my circumstances, and a Phase 2. I hope I am making the right decision.
Dx 7/11, Stage IIIc CC
12 txs Folfox 8/2011-2/2012
MSS, KRAS-mut G12D
NED until 3/2015, mets to liver and peritoneum
April-December 2015: 15 txs folfiri+avastin
Liver mets resolved; pelvic met remains
January-May 2016: folfox+avastin; allergic rxn to oxi
June-August 2016: 5FU+avastin
October 2016: looking into immuno trial
January 2017: maintenance chemo xeloda + avastin


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