MSS-CRC Trial: Phase 2 Study of GVAX (With CY) and Pembrolizumab in MMR-p Advanced Colorectal Cancer

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DK37
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MSS-CRC Trial: Phase 2 Study of GVAX (With CY) and Pembrolizumab in MMR-p Advanced Colorectal Cancer

Postby DK37 » Wed Dec 07, 2016 5:56 am

Here is a new MSS-CRC immunotherapy trial opening up at Johns Hopkins:

"Phase 2 Study of GVAX (With CY) and Pembrolizumab in MMR-p Advanced Colorectal Cancer"
https://clinicaltrials.gov/ct2/show/NCT02981524

It uses a very cool genetically modified listeria technology as therapeutic vaccine + a PD1 inhibitor.
Like all therapeutic vaccines, this technology has shown limited clinical efficacy in the past but many scientists believe that by now adding a PD1 inhibitor, there is a reasonable chance that clinical efficacy may happen.

Time & clinical trial testing will tell but I think there is a chance that a number of previously disappointing technologies (vaccination, oncolytic viruses etc) may be reinvigorated via PD1 inhibitor combo trials.

Cheers,
-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
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CRguy
Posts: 9638
Joined: Sun Feb 10, 2008 6:00 pm

Re: MSS-CRC Trial: Phase 2 Study of GVAX (With CY) and Pembrolizumab in MMR-p Advanced Colorectal Cancer

Postby CRguy » Wed Dec 07, 2016 6:24 pm

I am luvvin' the " everything old is new again " mindset with some of these new combo trials !!!!!!

The CY is harsh ole skule chemo and the GVAX is kind of "tamed" Coley's toxin 2.0 !
with hot off the presses PD-1 inhibitors .......

THIS IS very cool stuff my friend
VERY cool

Cheers and Best wishes
CRguy
Caregiver x 3
Stage IV A rectal cancer/lung met
11 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far


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