Turned down for HIPEC

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mrsv
Posts: 2
Joined: Thu Jun 12, 2014 9:35 pm

Turned down for HIPEC

Postby mrsv » Tue Dec 06, 2016 2:33 am

I was turned down for HIPEC after a small node showed up on my lung. I have 4 nodes in my peritoneal area and it was recommended by the NIH that I have the surgery. Does anyone know of a doctor on the west coast who might perform the surgery in my situation. I have already had 10 rounds of FOLFOX.

dudette
Posts: 106
Joined: Sat Oct 17, 2015 10:04 am

Re: Turned down for HIPEC

Postby dudette » Tue Dec 06, 2016 10:45 am

PIPAC might be an option for you. It's a relatively new, minimal invasive procedure for peri mets. Maybe surgeons are more willing to work with you if the surgery is less challenging for the patient?!?

The following link can get you started with finding a clinic/hospital that performs this surgery:

http://www.newswise.com/articles/mercy-medical-center-in-baltimore-hosts-3rd-international-pressurized-intraperitoneal-aerosol-chemotherapy-pipac-symposium
Temi
Dx 03/2015 @ age 41 - CC stage IV - pT3 N2b (14/29) cM1 (hep) L1 V1 Pn1 R1
Wild K-RAS, N-RAS, BRAF / MSS
unresectable mets liver 60% + lungs
Surgery
04/15 - sigmoid resect.
07/16 - hysterectomy (ovaries)
Chemo
05-06/15 - 4 x Folfirinox
12/15 - 02/16 4 x Xeliri + Avastin
03-05/16 9 x Xeloda
09-12/16 Folfiri + Cetuximab
01/2017 - metronomic chemo + methadone
July 20, 2107 - Temi has passed away.

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Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Re: Turned down for HIPEC

Postby Maia » Tue Dec 06, 2016 12:01 pm

But that was only a simposium, dudette... PIPAC is not performed on the States yet. I'm in touch with the doctor who invented this, Prof Marc Reymond (I met him personally on September, he came to Argentina! : ), precisely waiting to hear from him if things have changed. I have a post/ whole thread prepared about PIPAC. I'll post in the next days.

In the meantime:
"The method of Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) allows the dispersion of chemotherapeutic agents within the peritoneal cavity by means of minimal-invasive techniques. Even if PIPAC represents a new treatment modality, it is not an experimental treatment. Over a thousand applications have been performed in few specialized centers in Europe rendering promising results.PIPAC is a surgical procedure that can only be applied by laparoscopy. The fumigation as a gas allows a homogeneous dispersion of chemotherapy within the peritoneal cavity; the administration under pressure (standard in laparoscopic surgery) increases the local tissue penetration of the molecules allowing high intratumoral concentrations. The procedure is performed under general anesthesia. Two trocars are inserted via two small incisions (5-12 mm) into the peritoneal cavity; the subsequent air insufflation grants the necessary workspace (schema). First, small tissue samples of the tumor knots are retrieved (biopsy). Then, the chemotherapy is dispersed as pressurized aerosol inside the peritoneal cavity, acting during 30 minutes. At the end of the procedure, the pressure is released and the gas aspirated, and the skin incisions are closed. The whole procedure lasts about 90 minutes. The length of hospital stay is usually 3 days. Today, 3 applications are recommended within 3 months (delay between the applications: 6 weeks). "

Prof. Reymond: https://www.youtube.com/watch?v=daxKArtpjtQ (German)
http://www.capnomed.de/
A folder with documentation here: https://drive.google.com/open?id=0Bwc5k ... nNsdkZuN1U

tigerpaw
Posts: 57
Joined: Sat Jun 20, 2015 1:34 pm
Facebook Username: kristin.lossius
Location: Norway

Re: Turned down for HIPEC

Postby tigerpaw » Tue Dec 06, 2016 1:14 pm

I had HIPEC in Norway and was accepted with one lung met, so practice varies. I still have 2 small lung mets, but no peritoneal recurrence and enjoying life treatment free. There must be some surgeons who will accept you for HIPEC with one lung met.
63y female
dx July 13 resection of primary in sigmoid colon
Stage 3B cc, T3N1M0
KRAS mutant, codon 12/13, MSS
FLOX (FLV infusion 2 consecutive days + oxi) August 2013. Oxi stopped after 8tx
clear CT 6/14
peri mets + lung met 12/14
1/15 HIPEC
3/15 Lung resection
8/15 Subcutaneous met in midline abdomen-resected
8/15 Two lung nodules, observation, no chemo
2/17 enlarged lymph nodes hilus and mediastinum
5-8/17 FLV + Avastin
3/18 radiation to mediastinal and hilar lymph nodes

dudette
Posts: 106
Joined: Sat Oct 17, 2015 10:04 am

Re: Turned down for HIPEC

Postby dudette » Tue Dec 06, 2016 1:29 pm

D'oh! Of course you are right, Maia. I thought that the US was already on board with this new technique.
Temi
Dx 03/2015 @ age 41 - CC stage IV - pT3 N2b (14/29) cM1 (hep) L1 V1 Pn1 R1
Wild K-RAS, N-RAS, BRAF / MSS
unresectable mets liver 60% + lungs
Surgery
04/15 - sigmoid resect.
07/16 - hysterectomy (ovaries)
Chemo
05-06/15 - 4 x Folfirinox
12/15 - 02/16 4 x Xeliri + Avastin
03-05/16 9 x Xeloda
09-12/16 Folfiri + Cetuximab
01/2017 - metronomic chemo + methadone
July 20, 2107 - Temi has passed away.

Stanfordmom
Posts: 612
Joined: Wed May 14, 2014 1:32 am

Re: Turned down for HIPEC

Postby Stanfordmom » Wed Dec 07, 2016 3:20 am

Hi There,

Dr. alessio Pigazzi at UC Irvine performed HIPEC for one of my friends who also had a lung nodule at the time. He is supposedly VERY good.

Best wishes for your upcoming treatment.

Sha
DX 4/2/2014 at 44, stage 4, mets liver and ovaries
Mom to 2 boys
Three surgeries, HAI pump and lots of chemo
fighting!

User avatar
ktwmn
Posts: 350
Joined: Tue Aug 02, 2011 9:41 am

Re: Turned down for HIPEC

Postby ktwmn » Wed Dec 07, 2016 5:06 pm

I had not heard of the PIPAC procedure before, it sounds very promising. Thanks for sharing, dudette. I look forward to reading your update on this procedure and its potential in the US, Maia!
Dx 7/11, Stage IIIc CC
12 txs Folfox 8/2011-2/2012
MSS, KRAS-mut G12D
NED until 3/2015, mets to liver and peritoneum
April-December 2015: 15 txs folfiri+avastin
Liver mets resolved; pelvic met remains
January-May 2016: folfox+avastin; allergic rxn to oxi
June-August 2016: 5FU+avastin
October 2016: looking into immuno trial
January 2017: maintenance chemo xeloda + avastin


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