Postby emzee » Thu Jan 05, 2017 3:13 pm
Hi, I just posted today regarding my own PALN recurrences over the past 3 years. Mine are not resectable, have not responded to chemo, got some traction with SBRT but since I've had it there twice, I am unable to have it there again. I've been on 5FU, FOLFOX, FOLFIRI (I have an intolerance to Irinotecan so it is now permanently off the table) and Stivarga. My oncologist is thinking maintenance chemo either back to low dose 5FU infused or Xeloda oral...I'm thinking I'll go with 5FU as I already have neuropathy from FOLFOX and do not want the HFS that comes with Xeloda. I kinda did OK with 5FU before, not that it stopped anything long term, but I managed it fairly well while undergoing radiation at initial diagnosis.
I've been scouring the 'net trying to find more intel about PALN and colorectal cancer and cannot find much. It seems to be more prevalent with other types of cancer (breast, prostate). Interestingly and sadly, my 76 year old dad passed from bladder cancer last April. His mets were expected to be in the PALN area but he was clean there, his spread was to his liver and spine. I've already had liver mets so I'm thinking there is definitely some kind of weird deviation from "normal" CRC mets. My oncologist (I'm in Chicago at an academic center) treats nothing but CRC and said that my mets are not typical and that I should not expect anything we do to be curative. It sucks (well, all cancer sucks regardless of where and stage) since I'm 52 and been slugging this out for over 6 years AND am in good health otherwise. If anyone has some info, personal experience, etc. please post. Thank you!
Best, Emzee
Dx Nov'10 Stage III rectal CA
Dec'10-11 F5U & 25 rad Txs
Mar'11 res,temp ostomy,pos nodes
Mar'11-Nov '11 FOLFOX 12 Txs
Feb'12 CEA elev;liver tum,Stage IV
Mar'12 Liver res, gallbladder out,ostomy rev
Feb'14 Elev CEA Pos para-aortic lymph nodes
May '14-Aug'14 FOLFIRI + Avastin (6 rnds, red. dose)
Sept-Oct '14 SBRT nodes
Sept'15 CEA elev,new PALN pos
Oct-Nov '15 SBRT nodes
Feb '16 CEA elev,new PALN pos
Apr-May Red dose Stivarga
Oct '16 CEA elev,new PALN pos
'18 mult sm lung mets, PALNs; CEA UP, maint. 5FU