UPDATE March 2017: ARMS added. Important news: Nivo + Ipi + other agents / MSS and MSI-CRC Immunotherapy Trial

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Maia
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UPDATE March 2017: ARMS added. Important news: Nivo + Ipi + other agents / MSS and MSI-CRC Immunotherapy Trial

Postby Maia » Mon Nov 28, 2016 11:46 am

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UPDATE March 2017: two more arms added, one for MSS and other for MSI. Read post below, in this thread.
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Since years ago, we have been following on this forum immunotherapy trials that combine nivolumab (and PD-1) plus ipilimumab (anti CTLA-4). Very soon we learnt that the slots for MSS patients were few and, over the years, we also saw that it was showing activity only for those MSI tumours, anyway.
Recently this year, a trial that combines a PD-1 inhibitor with a MEK inhibitor, cobimetinib, showed success, finally, for MSS CRC: viewtopic.php?f=1&t=54825

Now, this past month, the big trial for nivo + ipi has updated its protocol to include that cobimetinib for the MSS arm:

A Study of Nivolumab and Nivolumab Plus Ipilimumab in Recurrent and Metastatic Colon Cancer (CheckMate 142)
+ cobimetinib for the MSS arm:
https://clinicaltrials.gov/ct2/show/NCT02060188

Many locations, worldwide too.
Last edited by Maia on Fri Mar 24, 2017 8:49 am, edited 2 times in total.

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juliej
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Re: Important news: Nivo + Ipi + Cobimetinib trial / MSS-CRC Immunotherapy Trial

Postby juliej » Mon Nov 28, 2016 5:29 pm

Thanks for the update, Maia! :D

It's starting to look like MSS-CRC can be sensitized for immune therapy by including a MEK inhibitor. The Phase 1 cobimetinib (cobi) and atezolizumab (atezo) trial showed good success but it was a very small trial (23 patients). This one has 32 locations so we'll be getting much more data. Keep up the good work, immunotherapy researchers!
Stage IVb, liver/lung mets 8/4/2010
Xelox+Avastin 8/18/10 to 10/21/2011
LAR, liver resec, HAI pump 11/2011
Adjuvant Irinotecan + FUDR
Double lung surgery + ileo reversal 2/2012
Adjuvant FUDR + Xeloda
VATS rt. lung 12/2012 - benign granuloma!
VATS left lung 11/2013
NED 11/22/13 to 12/18/2019, CEA<1

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Maia
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Re: Important news: Nivo + Ipi + Cobimetinib trial / MSS-CRC Immunotherapy Trial

Postby Maia » Mon Nov 28, 2016 6:35 pm

My dear zombie killer buddy! So happy to see you! Remember our old promise --I'm here to help you if you need a pal to fight zombies during the Apocalypse. And the doors of my home are open for you, if you need to put distance between the crazies and you. I'm too way south for them (and they won't be able to pinpoint Argentina on a map :lol: :wink: =

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ktwmn
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Re: Important news: Nivo + Ipi + Cobimetinib trial / MSS-CRC Immunotherapy Trial

Postby ktwmn » Tue Nov 29, 2016 2:51 pm

Thanks for the update, Maia. Last summer I applied for the Checkmate 142 trial but because my tumor was MSS I could not participate. Good to hear that the experimental arm is now open for MSS patients! I emailed the oncologist I was working with at Duke about it, although I don't know if all sites will have that arm open. In the meantime, I am looking into the atezo+bevacizumab+capecitabine https://clinicaltrials.gov/ct2/show/NCT02873195 which is not yet recruiting participants. Yes, it's a brave new world!!

P.S. I'm so glad to see you back on the forum, Maia!
Dx 7/11, Stage IIIc CC
12 txs Folfox 8/2011-2/2012
MSS, KRAS-mut G12D
NED until 3/2015, mets to liver and peritoneum
April-December 2015: 15 txs folfiri+avastin
Liver mets resolved; pelvic met remains
January-May 2016: folfox+avastin; allergic rxn to oxi
June-August 2016: 5FU+avastin
October 2016: looking into immuno trial
January 2017: maintenance chemo xeloda + avastin

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Maia
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Joined: Fri Aug 24, 2012 8:00 am

Re: Important news: Nivo + Ipi + Cobimetinib trial / MSS-CRC Immunotherapy Trial

Postby Maia » Tue Nov 29, 2016 4:33 pm

Hey, thank you, ktwmn, you're very kind. I was here, just reading (I was counting on DK37 to bother all of you to no end with immunotherapy, instead of me LOLOL)
That trial NCT02873195 has an interesting combination of chemo (cape/Xeloda), plus the immuno (Atezo) and the monoclonal antibody (Avastin). A con is the randomization aspect, but well, you never know. : )
Are you in MN, then? Looking for trials there, only? Your signature says you're dealing with peri mets... are they resolved?

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ktwmn
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Re: Important news: Nivo + Ipi + Cobimetinib trial / MSS-CRC Immunotherapy Trial

Postby ktwmn » Tue Nov 29, 2016 8:27 pm

Hey Maia, I will PM you.
Dx 7/11, Stage IIIc CC
12 txs Folfox 8/2011-2/2012
MSS, KRAS-mut G12D
NED until 3/2015, mets to liver and peritoneum
April-December 2015: 15 txs folfiri+avastin
Liver mets resolved; pelvic met remains
January-May 2016: folfox+avastin; allergic rxn to oxi
June-August 2016: 5FU+avastin
October 2016: looking into immuno trial
January 2017: maintenance chemo xeloda + avastin

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ramg_sg
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Re: Important news: Nivo + Ipi + Cobimetinib trial / MSS-CRC Immunotherapy Trial

Postby ramg_sg » Wed Nov 30, 2016 4:31 am

I met Trial Onc in Singapore. He has ordered additional tests on the stuff removed from me. Though I am MSS (Microsatellite Stable), there is one combination he said that he can try, if my current FOLFIRI + Zaltrap is not working.
Age 53[2016]
07/13 Tumor discovery
08/13 CC surgery, 9/12 Lymph nodes, Temp Ileostomy T3 N2b S3C KRAS+
08/13 to 01/14 - FOLFOX+Bev & Zometa, 5FU 24x7 CEA normal
02/14 RT
04/14 Ileostomy reversal
05/14 to 06/15 - 5FU 24x7
06/15 Fix Hernia Ileostomy site
06/15 to 02/16 - 5FU 24x7
02/16 PET tumor size increase - FOLFOX+Bev
05/16 RT
07/16 PET - spots in lungs, surgery option drop
Microsatellite stable
09/16 PET - FOLFOX not shrinking tumors
09/16 FOLFIRI+Bev - 3 cycles
11/16 FOLFIRI+Zaltrap - 3 cycles

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Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Re: Important news: Nivo + Ipi + Cobimetinib trial / MSS-CRC Immunotherapy Trial

Postby Maia » Wed Nov 30, 2016 4:41 am

ramg_sg wrote:I met Trial Onc in Singapore. .


Do you mean this trial is available in Singapore, it's one of the locations?

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ramg_sg
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Joined: Tue Oct 04, 2016 1:28 am

Re: Important news: Nivo + Ipi + Cobimetinib trial / MSS-CRC Immunotherapy Trial

Postby ramg_sg » Wed Nov 30, 2016 5:07 am

Maia wrote:
ramg_sg wrote:I met Trial Onc in Singapore. .


Do you mean this trial is available in Singapore, it's one of the locations?


Singapore is collaborating with US and EU. It depends on when I become 'eligible' for the trial and availability of slot. Also it depends on what phase the trial drug is.....
Age 53[2016]
07/13 Tumor discovery
08/13 CC surgery, 9/12 Lymph nodes, Temp Ileostomy T3 N2b S3C KRAS+
08/13 to 01/14 - FOLFOX+Bev & Zometa, 5FU 24x7 CEA normal
02/14 RT
04/14 Ileostomy reversal
05/14 to 06/15 - 5FU 24x7
06/15 Fix Hernia Ileostomy site
06/15 to 02/16 - 5FU 24x7
02/16 PET tumor size increase - FOLFOX+Bev
05/16 RT
07/16 PET - spots in lungs, surgery option drop
Microsatellite stable
09/16 PET - FOLFOX not shrinking tumors
09/16 FOLFIRI+Bev - 3 cycles
11/16 FOLFIRI+Zaltrap - 3 cycles

User avatar
Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Re: Important news: Nivo + Ipi + Cobimetinib trial / MSS-CRC Immunotherapy Trial

Postby Maia » Wed Nov 30, 2016 5:23 am

So, are you in Singapore? Have you hear anything about Recombinant super-compound interferon, an immunotherapy? There is a trail there, for CRC: https://clinicaltrials.gov/ct2/show/NCT02387307

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Maia
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Joined: Fri Aug 24, 2012 8:00 am

Re: Important news: Nivo + Ipi + Cobimetinib trial / MSS-CRC Immunotherapy Trial

Postby Maia » Sun Dec 04, 2016 5:27 pm

ktwmn wrote:Last summer I applied for the Checkmate 142 trial but because my tumor was MSS I could not participate. Good to hear that the experimental arm is now open for MSS patients! I emailed the oncologist I was working with at Duke about it, although I don't know if all sites will have that arm open.!


ktwmn, I've just got the news that Duke opened a cohort of NCT02060188 (Nivolumab + Ipilimumab) for MSS CRC.

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juliej
Posts: 3114
Joined: Thu Aug 05, 2010 12:59 pm

Re: Important news: Nivo + Ipi + Cobimetinib trial / MSS-CRC Immunotherapy Trial

Postby juliej » Wed Dec 07, 2016 7:08 pm

Maia wrote:My dear zombie killer buddy! So happy to see you! Remember our old promise --I'm here to help you if you need a pal to fight zombies during the Apocalypse. And the doors of my home are open for you, if you need to put distance between the crazies and you. I'm too way south for them (and they won't be able to pinpoint Argentina on a map :lol: :wink: =

Yes, I am still here, armed and ready for the zombie apocalypse! We'll fight back to back, remember? You, me, and a circle of dead zombies around us! If I can get to Argentina, we'll have alfajores and coffee and plot our attack.

It's so good to see your brilliant mind back here helping people out. I know one of the nivo/ipi/cobi researchers. Will see if I can get an update from him about the trial. The most important thing is that they are starting phase 2. Finally, MSS patients are getting in on the immuno action!

xo xo xo!
juliej
Stage IVb, liver/lung mets 8/4/2010
Xelox+Avastin 8/18/10 to 10/21/2011
LAR, liver resec, HAI pump 11/2011
Adjuvant Irinotecan + FUDR
Double lung surgery + ileo reversal 2/2012
Adjuvant FUDR + Xeloda
VATS rt. lung 12/2012 - benign granuloma!
VATS left lung 11/2013
NED 11/22/13 to 12/18/2019, CEA<1

User avatar
ramg_sg
Posts: 35
Joined: Tue Oct 04, 2016 1:28 am

Re: Important news: Nivo + Ipi + Cobimetinib trial / MSS-CRC Immunotherapy Trial

Postby ramg_sg » Mon Dec 12, 2016 4:40 am

Maia wrote:So, are you in Singapore? Have you hear anything about Recombinant super-compound interferon, an immunotherapy? There is a trail there, for CRC: https://clinicaltrials.gov/ct2/show/NCT02387307


Thanks for the info. Will check with my Onco this week.
Age 53[2016]
07/13 Tumor discovery
08/13 CC surgery, 9/12 Lymph nodes, Temp Ileostomy T3 N2b S3C KRAS+
08/13 to 01/14 - FOLFOX+Bev & Zometa, 5FU 24x7 CEA normal
02/14 RT
04/14 Ileostomy reversal
05/14 to 06/15 - 5FU 24x7
06/15 Fix Hernia Ileostomy site
06/15 to 02/16 - 5FU 24x7
02/16 PET tumor size increase - FOLFOX+Bev
05/16 RT
07/16 PET - spots in lungs, surgery option drop
Microsatellite stable
09/16 PET - FOLFOX not shrinking tumors
09/16 FOLFIRI+Bev - 3 cycles
11/16 FOLFIRI+Zaltrap - 3 cycles

User avatar
ramg_sg
Posts: 35
Joined: Tue Oct 04, 2016 1:28 am

Re: Important news: Nivo + Ipi + Cobimetinib trial / MSS-CRC Immunotherapy Trial

Postby ramg_sg » Wed Dec 28, 2016 5:25 am

I am recommended to try out Selinexor (KPT-330) - it is on Phase 1B in Singapore. Will be meeting the Trial Onco soon and will update.
Age 53[2016]
07/13 Tumor discovery
08/13 CC surgery, 9/12 Lymph nodes, Temp Ileostomy T3 N2b S3C KRAS+
08/13 to 01/14 - FOLFOX+Bev & Zometa, 5FU 24x7 CEA normal
02/14 RT
04/14 Ileostomy reversal
05/14 to 06/15 - 5FU 24x7
06/15 Fix Hernia Ileostomy site
06/15 to 02/16 - 5FU 24x7
02/16 PET tumor size increase - FOLFOX+Bev
05/16 RT
07/16 PET - spots in lungs, surgery option drop
Microsatellite stable
09/16 PET - FOLFOX not shrinking tumors
09/16 FOLFIRI+Bev - 3 cycles
11/16 FOLFIRI+Zaltrap - 3 cycles

User avatar
Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Re: Important news: Nivo + Ipi + Cobimetinib trial / MSS-CRC Immunotherapy Trial

Postby Maia » Wed Dec 28, 2016 9:17 am

Hi there. Posted some info for you in your other thread, specific about Selinexor (KPT-330).


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