BeckyH wrote:.. I am new to this board and looking for education and perhaps inspiration.
Thank you in advance.
Signet ring cell carcinoma of the colon and rectum
"This variant of adenocarcinoma is defined by the presence of > 50% of tumour cells with prominent intracytoplasmic mucin, typically with displacement and moulding of the nucleus. Signet-ring cells can occur within the pools of mucinous adenocarcinoma or in a diffusely infiltrative process with minimal extracellular mucin in a linitis-plastica pattern. Large signet-ring cells can be termed "globoid cells". Some signet ring cell carcinomas are MSI-H and are low-grade, but those that lack MSI-H are usually highly aggressive. Carcinomas with signet-ring cell areas of < 50% are categorized as adenocarcinoma with a signet-ring cell component."
Ref: WHO (World Health Organization) (2010). Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System (4th edition). Bosman FT, Carneiro F, Hruban RH and Theise ND. IARC Press, Lyon.
Maia wrote:Hi, Becky!
Sorry you need to be here but glad you have found great folks as those who replied you here.
Do you know if your tumour has been tested for MSS/ MSI? That opens a door to other possible, specific therapies, in recent years, like immunotherapies.
Wanted to direct you to other fellow who has SRC (and is MSI), receiving immunotherapy that has kept her stable after chemo failure: viewtopic.php?f=1&t=56560&start=15#p447261
I hope your scan is wonderful and you don't need anything of this! But just keep in mind that if it is not, it can be manageable.
Goldfish wrote:Hi Becky,
You indeed have found a bunch of great people, including the always helpful splendid and very well informed Maia.
I am Stage IV SR CRC (Sigmoid, 8/39 nodes) for 18 months now. Sigmoid tumor removed with 1 peri-mets, and a LAMN tumor in my appendix in July 2015. Three months of CapOx followed by HIPEC (dec 2015, three more peri mets killed) and another three months of CapOx. Yesterday I got a clean CT and great bloodwork back, so I am technically 1 year NED.
Yes, SR cells are agressive and more difficult to visualize on scans. Yes, prognosis is poorer (about half of the overall average, roughly 30% instead of 60% for stage III) but they DO respond to chemo. A part of the poor prognosis is related to the location of metastasis, as SR cells tend to prefer to spread to the peritoneum first over lungs and liver. Peri mets are always very persistant.
I have read a dozen studies on SR so feel free! For instance about a study 2000+ SR cases (1989-2010) in the Netherlands.
A wise person (not Churchill) said once: There are lies, huge lies and statistics.
I'm new to this so I hope I'm doing it right. My husband has signet ring cell colon with mets to paritoneal cavity. He is MSS. Can anyone offer me any help?
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