Peri Mets / MSS-CRC Immunotherapy Trial (Oncolytic Virus + anti-PDL1)

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Peri Mets / MSS-CRC Immunotherapy Trial (Oncolytic Virus + anti-PDL1)

Postby DK37 » Sat Nov 19, 2016 9:07 am


I know there has been a lot of interest in the oncolytic virus + PD(L)1 inhibitor strategy after I recently signed up for the NCT02636036 trial. I also wanted to post this because peri mets can be resistant to chemotherapy.

It is one experimental strategy to try to convert a cold MSS tumor into a highly inflamed tumor which "looks more like" a MSI-high CRC or HPV+ tumor in that regard (all of which often respond to PD(L)1 inhibitors).

This new Oncolytic virus + PDL1 inhibitor trial is opening in January. Trial sites so far: NYC and Buffalo, NY. It is specifically recruiting CRC patients with peritoneal mets.

Their inclusion criteria on paper looks a bit strict (can you join after failing FOLFIRI or do you need to at least try TAS/Stivarga first?) but you can see how strictly they interpret it by presenting your medical situation and seeing what they say.

6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder:
2016 Colondar 2.0 Model
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Location: Ontario, Canada

Re: Peri Mets / MSS-CRC Immunotherapy Trial (Oncolytic Virus + anti-PDL1)

Postby Steph20021 » Tue Nov 22, 2016 10:08 pm

I'll be keeping this on my radar. Thank you.
DX 1/31/14 @ 33- SPS-T4a(invades visceral peri), N2a(6/106 LN), M1a(ovary) (Stage 4a) MSS; BRAF V600E
2/1/14-subtotal col, lost R ovary, temp ileo
3/14-9/14- folfox; sepsis
11/14-CT/PET: L ovary met, pelvic met, (?)ghost liver met(?)
12/14-folfiri -13 rds kept me stable from 3/15-6/15
09/15- cea 0.9
05/16- recurrence in abdo wall and lymph nodes
01/17- pulmonary embolism
02/17- 1 wk radiation to abdo wall
08/16- on folfiri
11/18- Beacon trial-encorafenib & cetuximab

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Re: Peri Mets / MSS-CRC Immunotherapy Trial (Oncolytic Virus + anti-PDL1)

Postby Maia » Tue Feb 14, 2017 1:03 pm

Update today on the ONCOS-102 trial (NCT02963831) from Ludwig Institute:
"The study is not yet recruiting patients, but we hope that it will be opened in the next few months. We will have sites in New York City, Buffalo, NY and Miami, Florida."

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