What does KRAS Wild mean?

[ronswife]

Hello Again,

The onc told us today that Ron's cancer is KRAS wild. What does this mean? I am too drained right now to even look this up!

Generally, is this good or BAD?

I had an eye exam last Monday, 10/24, and was told I have mild cataracts in both eyes. The left one is worse.

I feel that we just CAN'T catch a BREAK!

[Nik Colon]

No mutation

https://en.m.wikipedia.org/wiki/KRAS

http://emedicine.medscape.com/article/1 ... verview#a1

https://www.mycancergenome.org/content/ ... r/kras/44/

[CRguy]

...AND clinically speaking :
possibly able to use EGFR inhibitors which KRAS mutant tumors will not benefit from

KRAS mutation is predictive of a very poor response to panitumumab (Vectibix®) and cetuximab (Erbitux®) therapy in colorectal cancer

wild type is a GOOD thing ... in a nutshell !

best wishes
CR

[Nik Colon]

I still don't get why it's called "wild type"

Since you know, you could add it to your sig (KRAS-wt)
also MSI (H or L) or MSS, if you know.

These are important for tx options

[GrouseMan]

Is called "Wild" because it is natural not a mutation. Out of the wild if you will. This is a term used to talk about mutations and genetics for a very long time. People doing genetic research and looking for mutations bred mice in a particular way to enhance these mutations. These mice are not wild but usually double positive or double negative carriers of particular mutations, that are passed on to their offspring. Thus when describing the mutation is against the "wild" variant of the mice that don't carry the mutation.

Wikipedia has a better definition:

https://en.wikipedia.org/wiki/Wild_type

Regards,

GrouseMan

[Nik Colon]

Is called "Wild" because it is natural not a mutation. Out of the wild if you will. This is a term used to talk about mutations and genetics for a very long time. People doing genetic research and looking for mutations bred mice in a particular way to enhance these mutations. These mice are not wild but usually double positive or double negative carriers of particular mutations, that are passed on to their offspring. Thus when describing the mutation is against the "wild" variant of the mice that don't carry the mutation.

Wikipedia has a better definition:

https://en.wikipedia.org/wiki/Wild_type

Regards,

GrouseMan

Interesting! Thanks GM! I love learning new things

[CRguy]

very Very VERY ... basic explanation from memory :
wild type refers to the generally accepted "naturally" occurring allele of a gene locus in a population, aka "normal", aka not mutated.

so a geneticist would look at a particular gene locus on a chromasome and "normally" find the wild type "gene" there
( actually allele which is a variant of the gene at that location )

changes or variants of that gene ( allele ) which are not the "normal" wild type would be considered mutations.

so KRAS wild type is the "normal" gene at a certain locus on the human genome

KRAS mutations are not the wild (aka normal) type and would have different properties than the wild type,
which in this case means NOT responding to treatments with the drugs mentioned above


sorry guess not that simple/ basic after all ... which is why we have folks like GrouseMan and DK37 hanging around here !

JUST saw his feedback = listen to him

Cheers
CR

[Nik Colon]

very Very VERY ... basic explanation from memory :
wild type refers to the generally accepted "naturally" occurring allele of a gene locus in a population, aka "normal", aka not mutated.

so a geneticist would look at a particular gene locus on a chromasome and "normally" find the wild type "gene" there
( actually allele which is a variant of the gene at that location )

changes or variants of that gene ( allele ) which are not the "normal" wild type would be considered mutations.

so KRAS wild type is the "normal" gene at a certain locus on the human genome

KRAS mutations are not the wild (aka normal) type and would have different properties than the wild type,
which in this case means NOT responding to treatments with the drugs mentioned above


sorry guess not that simple/ basic after all ... which is why we have folks like GrouseMan and DK37 hanging around here !

JUST saw his feedback = listen to him

Cheers
CR

Thanks! I assume you were writing at the same time

[Nik Colon]

Hello Again,

The onc told us today that Ron's cancer is KRAS wild. What does this mean? I am too drained right now to even look this up!

Generally, is this good or BAD?

I had an eye exam last Monday, 10/24, and was told I have mild cataracts in both eyes. The left one is worse.

I feel that we just CAN'T catch a BREAK!

Sorry about your eyes maybe not the same, but that's my life in a nutshell, one thing bad after another, ugh
So, I hear ya!

[Nik Colon]

Wanted to add. I don't know your belief. Me personally, I believe but don't follow any belief system.

So my point. Not sure where from, but I recall hearing...the more you suffer, the closers you are to God/Jesus.

I don't believe that, but, if so, I feel my family, and all of us here (well maybe not all, lol j/k) are really close to them then.

They "really love us"!

Again, no hate! I do believe in a God/afterlife/something

[ronswife]

Thank ALL of you so much for your informational, compassionate and amusing posts!!

I LOVE this colon family!!

[ramg_sg]

I got KRAS Positive, which the Onco said it is good. My cancel is not wild and spread can be controlled. It worked for 2.5 years. Now it has spread.. so will have to see.