DK37's First MSS-CRC Immunotherapy Clinical Trial (Oncolytic Virus + PD1)

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DK37
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Location: San Diego

DK37's First MSS-CRC Immunotherapy Clinical Trial (Oncolytic Virus + PD1)

Postby DK37 » Sun Oct 16, 2016 4:39 am

A very exciting medical update - I was just approved for my first immunotherapy clinical trial! It is a mixture of an oncolytic virus + PD1 inhibitor.

The full story and how it fell unexpectedly into my lap at the link! https://adventuresinlivingterminallyopt ... l-trial-1/

My overall strategy over the past year and a half has been to lay the groundwork for trials, working around my melanoma issue. I have absolutely zero intention of dying of CRC in my 40’s. Not if I have any say in the matter!

The way I always picture it: My goal is to line up clinical trials like planes on a taxiway… Time for the first flight to take off!

Exciting days lay ahead in the very near future!

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

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WriterGirl1969
Posts: 493
Joined: Sat Mar 05, 2016 3:48 pm
Location: Central NY

Re: DK37's First MSS-CRC Immunotherapy Clinical Trial (Oncolytic Virus + PD1)

Postby WriterGirl1969 » Sun Oct 16, 2016 10:41 am

That's awesome DK. I love your plan... and here's hoping you don't even need it because the first one is so wildly successful!!! We'll be keeping an eye on your results.
--Tracy
DX 3/4/2016 Colon Cancer; age 46 Mom of 4-yr-old
Stage IIIB: T3N1M0
3/31/16 Left Hemi
4 to 10/2016: Xeloda Monotherapy
CEA: 10/16 0.56, 1/17 0.54
3/6/17 CT clear; 4/17/18 CT clear;
NED 2 years
“If I can help somebody as I walk along, then my living shall not be in vain.”

testing765
Posts: 313
Joined: Tue Aug 19, 2014 9:41 am

Re: DK37's First MSS-CRC Immunotherapy Clinical Trial (Oncolytic Virus + PD1)

Postby testing765 » Sun Oct 16, 2016 10:57 am

I wish you the best in this trial and I commend you for your courage and bravery during uncertain times. Let's kill this CRC monster.
male-age 44 at diagnosis
8/14-clnscopy
8/14-CT scan,no mets
9/14-left colectomy,CEA 2.2 before surgery
pT2pN2bpM0
3 cm tumor in dscnding colon
7/23 pos LNs
low grade MSI stable
10/14-start folfox
1/15-CT & PET scan and sigmdoscopy- no mets
3/15-finish folfox
9/15- clnscopy- 3 polyps removed
10/15- CT scan, NED
10/16- CT scan, NED, CEA 1.6
10/17- clnscopy- 4 polyps removed, CT scan NED, CEA 1.8
10/14 1.9; 4/15 2.8; 5/15 2.4; 9/15 2.8; 12/15 3.1; 1/16 3.0; 4/16 2.5; 7/16 2.5; 10/16 1.6; 1/17 1.9

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CRguy
Posts: 9650
Joined: Sun Feb 10, 2008 6:00 pm

Re: DK37's First MSS-CRC Immunotherapy Clinical Trial (Oncolytic Virus + PD1)

Postby CRguy » Sun Oct 16, 2016 12:40 pm

DK37 wrote:My goal is to line up clinical trials like planes on a taxiway… Time for the first flight to take off!

" DK37. this is the tower
you are cleared for takeoff my friend ..... "

I hear the music from Top Gun playing
"... time to splash a few bogies ! "

This is great news and typical of you, absolutely on the cutting edge.
"Call the ball."
"Roger. Maverick has the ball."


and it couldn't be in better hands !!!!!!!!!

Cheers and Harmony bro'
kick ass
CRguy
Caregiver x 3
Stage IV A rectal cancer/lung met
11 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

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Nik Colon
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Joined: Thu Jan 08, 2015 3:35 pm
Location: MN

Re: DK37's First MSS-CRC Immunotherapy Clinical Trial (Oncolytic Virus + PD1)

Postby Nik Colon » Sun Oct 16, 2016 5:49 pm

Awesome! 8)
KRAS-mut G12V,MSS
Stage IVa Sig CC 2 lvr mets 1/12 Ln
(3, =<3 lng spots at dx til 5/16)
=T3N1aM1a 4cmX4mm (lng not included)
dx 12/2014 at age 39
CEA 1/15-4.9, 12/16-4.9 again
neoadj FOLFOX 1/15-3/15 (4tx, 3w/1wo oxi)
Col/Lvr surg 4/23/15 NED
adj FOLFIRI start 6/15-9/15 (8tx, 5w/3wo iri)
1 sml lvr spot/cyst
12/6/16 multi lung spots/mets?
No longer NED :(
My tx ongoing-start 1/20/15
Adding your SIGNATURE, etc

lpas
Posts: 1007
Joined: Wed Nov 19, 2014 11:11 pm

Re: DK37's First MSS-CRC Immunotherapy Clinical Trial (Oncolytic Virus + PD1)

Postby lpas » Sun Oct 16, 2016 6:00 pm

Really fantastic news, Tom. Wishing you the best!!!
11/14 Dx sigmoid CC @ 45yo
12/14 Colectomy + hysterectomy
Stage IIIB, T3N1bM0, 2/20 nodes, MSS, G2, KRAS(A146T), TP53, SMAD4, ERBB2, CEA 1.0
2/15-7/15 XELOX & Celebrex
3/16 Ovarian mass removed. Benign fibroid
9/16 clean scope
4/18 clean CT
Ongoing Celebrex, Tagamet & other carefully-targeted supplements
Post-chemo CEA 3.0, 2.5, 2.3, 2.0, 1.6, 1.3, 1.8, 2.1, 1.8, 2.0, 1.8, 1.9, 1.7, 1.5, 1.6, 1.5, 1.4, 1.4, 1.3, 1.3, 1.6, 1.6, 1.3, 1.4, 1.6, 2.2, 2.4, 2.1
Mom to a 4 & 6yo

KElizabeth
Posts: 400
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Facebook Username: KElizabeth
Location: Omaha

Re: DK37's First MSS-CRC Immunotherapy Clinical Trial (Oncolytic Virus + PD1)

Postby KElizabeth » Mon Oct 17, 2016 6:37 am

Great news. I'd say keep us posted, but that really does go without saying.
Thanks for posting.
Female age 39- ,2 teens.
Colon Cancer - DX March 2013
Age 34 at DX - Stage III B
Resection surgery -May 2013
FOLFOX - June, 2013 to Sept, 2013
5FU plus leukavorin Sept, 2013 to Dec, 2013
METs liver and lungs discovered Sept, 2015
KRAS - MSS
FOLFIRI plus Avastin - Sept, 2015 - July 2017
Durvalumab and Cediranib Sept 2017 Dec 17
FOLFOX with desensitization protocol - current

jortego128
Posts: 286
Joined: Sat Aug 15, 2015 7:47 am

Re: DK37's First MSS-CRC Immunotherapy Clinical Trial (Oncolytic Virus + PD1)

Postby jortego128 » Mon Oct 17, 2016 4:02 pm

Great news, I will pray that you win this war!
DM 57 yrs old dx 6/8/15 T:4a N:1b M:1
KRAS G12D and TP53 C242fs mutations
Poorly Differentiated, Prominent Signet Ring Component(~50%)
Microsatellite Stable, 3 of (13)lymph nodes positive
15 Liver mets, largest 3.2 cm
Prim. Resection, Right Hemicolectomy 6/21/15
Start Chemo 7/20/15
2 rounds FOLFOX, 1 round FOLFOX +Avastin
CT 8/28/15, met growth, largest 4.5cm
4 rounds FOLFOX+Avastin
CT 11/06/15 mets stable, lungs clear
Begin FOLFIRI+Avastin 11/17/15, Stop chemo 1/26/16
Entered Paradise 3/11/2016


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