No more vectibix for me!

[BeansMama]

Found out the oddest thing today when I went for my infusion.

Apparently my tumor pathology was redone by the pathologists at Levine when they received my tumor tissue.

They found I do in fact have a RAS mutation. It is not KRAS, my oncologist didn't say which exact one it was, just that it was a rare mutation that possibly was not tested for by my docs in Texas.

As a result the vectibix will not work. Kind of a bummer since the research I did on vectibix said it worked really well. I would have endured the rash for the tumor shrinking results.

My onc is also going to clarify the number of treatments my surgeon wants, he thinks they want too many and the surgery needs to be done sooner. So hopefully we will find out more after our next treatment. He is going to do the scan after the next round and we will see if we have any shrink of the large liver tumor.

Fingers crossed we get some good shrinkage!

[Nik Colon]

Because these signals result in cell growth and division, overactive Ras signaling can ultimately lead to cancer.[1] The 3 Ras genes in humans (HRas, KRas, and NRas) are the most common oncogenes in human cancer; mutations that permanently activate Ras are found in 20% to 25% of all human tumors and up to 90% in certain types of cancer (e.g., pancreatic cancer).[2] For this reason, Ras inhibitors are being studied as a treatment for cancer and other diseases with Ras overexpression.

https://en.m.wikipedia.org/wiki/Ras_subfamily

The frequency and distribution of RAS gene mutations are not uniform1, 191. KRAS is the isoform most frequently mutated (in 86% of RAS-driven cancers), followed by NRAS (in 11% of RAS-driven cancers) and, infrequently, HRAS (in 3% of RAS-driven cancers)

In colon and rectal carcinoma (CRC), KRAS is also the predominantly mutated isoform (in 86% of CRC), whereas NRAS mutations are infrequent (in 14% of CRC) and HRAS mutations have not been detected.

http://www.nature.com/nrd/journal/v13/n ... 9_BX1.html

[mypinkheaven]

My onc is also going to clarify the number of treatments my surgeon wants, he thinks they want too many and the surgery needs to be done sooner. So hopefully we will find out more after our next treatment. He is going to do the scan after the next round and we will see if we have any shrink of the large liver tumor.

Fingers crossed we get some good shrinkage!

Cripes! Well, no more rash for you - that's a good thing. I hope the Irinotecan is doing its work and shrinking that darn thing. I'm glad you'll be getting some information sooner than later!! Got my fingers crossed for you!

[Tnguyen]

Sorry hear about that mamabeans
Sadly vectibix also stopped working for my mom and her tumors grew bigger. I also had big hopes for vectibix as I read it worked really well for other people. She only had like 4 infusion...sad. But I wish you the best and hopefully you'll be back on track with a new treatment!

[BeansMama]

My onc is also going to clarify the number of treatments my surgeon wants, he thinks they want too many and the surgery needs to be done sooner. So hopefully we will find out more after our next treatment. He is going to do the scan after the next round and we will see if we have any shrink of the large liver tumor.

Fingers crossed we get some good shrinkage!

Cripes! Well, no more rash for you - that's a good thing. I hope the Irinotecan is doing its work and shrinking that darn thing. I'm glad you'll be getting some information sooner than later!! Got my fingers crossed for you!

I hope the irinotecan is doing its job too! Thank you for the finger crossing, I'm hoping the surgery happens sooner than originally thought.

[BeansMama]

Because these signals result in cell growth and division, overactive Ras signaling can ultimately lead to cancer.[1] The 3 Ras genes in humans (HRas, KRas, and NRas) are the most common oncogenes in human cancer; mutations that permanently activate Ras are found in 20% to 25% of all human tumors and up to 90% in certain types of cancer (e.g., pancreatic cancer).[2] For this reason, Ras inhibitors are being studied as a treatment for cancer and other diseases with Ras overexpression.

https://en.m.wikipedia.org/wiki/Ras_subfamily

The frequency and distribution of RAS gene mutations are not uniform1, 191. KRAS is the isoform most frequently mutated (in 86% of RAS-driven cancers), followed by NRAS (in 11% of RAS-driven cancers) and, infrequently, HRAS (in 3% of RAS-driven cancers)

In colon and rectal carcinoma (CRC), KRAS is also the predominantly mutated isoform (in 86% of CRC), whereas NRAS mutations are infrequent (in 14% of CRC) and HRAS mutations have not been detected.

http://www.nature.com/nrd/journal/v13/n ... 9_BX1.html

Thank you for that information Nik!! I will have to ask my onc exactly which one I have the next time I see him. I was so exhausted from sleep issues I didn't even think of it when he told me. I have slept the last two days pretty much.

I'm thinking is is probably the NRAS since that is the infrequent one. Leave it to me to end up with all the uncommon things

[MDK]

Hang tough Beans Mommy - we all have to!

Praying for you girl!

Marianne

[BeansMama]

Sorry hear about that mamabeans
Sadly vectibix also stopped working for my mom and her tumors grew bigger. I also had big hopes for vectibix as I read it worked really well for other people. She only had like 4 infusion...sad. But I wish you the best and hopefully you'll be back on track with a new treatment!

Thank you Tnuygen, sorry to hear the vectibix stopped working for your mom as well.

I had the same issue with Avastin when I was on Folfox, so no big surprise. I'm just hoping the irinotecan does its job and shrinks this tumor more.

I also wish the best to you and your mom. I will keep you both in my prayers.

[BeansMama]

Hang tough Beans Mommy - we all have to!

Praying for you girl!

Marianne

I am, and yes we do! We all have to keep fighting!

Thank you for the prayers, they are appreciated.

[teri3]

Fingers crossed and prayers sent that the new treatment works. Hang in there.

Hugs,
Teri

[fumaros]

I am hoping you get shrinkage and can have that surgery soon Beansmama. Stay fighting stay strong.

[Soccermom2boys]

Leave it to me to end up with all the uncommon things

It sure does feel like that doesn't it?! Like seriously, where are these kinds of odds when winning the Mega Millions lottery?! Oh Beans--you just like to keep us intrigued on here! You are always in my thoughts--when you kick this tumor and any lingering cancer cells to the curb life will be blissfully uneventful, that is what I hope for you!

Bummer about the vectibix not working for your picky cancer cells, but yay for no more rash! Keep on sharing any updates!

[BeansMama]

Leave it to me to end up with all the uncommon things

It sure does feel like that doesn't it?! Like seriously, where are these kinds of odds when winning the Mega Millions lottery?! Oh Beans--you just like to keep us intrigued on here! You are always in my thoughts--when you kick this tumor and any lingering cancer cells to the curb life will be blissfully uneventful, that is what I hope for you!

Bummer about the vectibix not working for your picky cancer cells, but yay for no more rash! Keep on sharing any updates!

I definitely think I am a fan of the oddities when it comes to this disease, I wish I had that kind of luck playing the lottery!!

Hoping to kick this disease to the curb! Still fighting for NED. I will keep the updates coming

[BeansMama]

I am hoping you get shrinkage and can have that surgery soon Beansmama. Stay fighting stay strong.

Thank you! I hope the surgery comes sooner! I have no plan to stop fighting at all.

[BeansMama]

Fingers crossed and prayers sent that the new treatment works. Hang in there.

Hugs,
Teri

Thank you!