Great article! I love the idea of a vaccine that is truly personalized and loaded with patient-specific neoantigens.
Current immunotherapies, as good as they are, still have the potential to be toxic since they function in that narrow gap between tumor immunity and autoimmunity. The use of neoantigens offers the possibility of a safer and more specific therapy. Perhaps combining a neoantigen vaccine with a checkpoint inhibitor might even improve its efficacy?
The immune cells in his blood lashed out at about a dozen of the peptides.
Yes! GO, Tom's immune cells, GO!